| Protein: | Mcm2-PA |
| Organism: | Drosophila melanogaster |
| Length: | 887 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mcm2-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
783.0 | [0..14] | [887..14] |
|
Region A: Residues: [1-171] |
1 11 21 31 41 51
| | | | | |
1 MDNPSSPPPN TPSDAAERRD LRAAMTSPVG DFEPFENEDE ILGDQTVRDE AEEEDGEELF 60
61 GDNMENDYRP MPELDHYDPA LLDDEDDFSE MSQGDRFAAE SEMRRRDRAA GIHRDDRDLG 120
121 FGQSDDEDDV GPRAKRRAGE KAAVGEVEDT EMVESIENLE DTKGHSTKEW V
|
| Detection Method: |  |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [172-393] |
1 11 21 31 41 51
| | | | | |
1 SMLGPRTEIA NRFQSFLRTF VDERGAYTYR DRIRRMCEQN MSSFVVSYTD LANKEHVLAY 60
61 FLPEAPFQML EIFDKVAKDM VLSIFPTYER VTTEIHVRIS ELPLIEELRT FRKLHLNQLV 120
121 RTLGVVTATT GVLPQLSVIK YDCVKCGYVL GPFVQSQNTE IKPGSCPECQ STGPFSINME 180
181 QTLYRNYQKI TLQESPGRIP AGRIPRSKDV ILLADLCDQC KP
|
| Detection Method: | |
| Confidence: | 46.69897 |
| Match: | 1ltlA |
| Description: | DNA replication initiator (cdc21/cdc54) N-terminal domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telomeric DNA binding | 4.81350293592083 | bayes_pls_golite062009 |
| telomerase inhibitor activity | 4.48082903165152 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 4.34033743483519 | bayes_pls_golite062009 |
| nucleic acid binding | 4.29626483284963 | bayes_pls_golite062009 |
| DNA binding | 3.71771169141041 | bayes_pls_golite062009 |
| structural constituent of ribosome | 3.51998515668903 | bayes_pls_golite062009 |
| structural molecule activity | 3.29857127235306 | bayes_pls_golite062009 |
| structure-specific DNA binding | 3.06066809614422 | bayes_pls_golite062009 |
| single-stranded DNA binding | 3.0183551365402 | bayes_pls_golite062009 |
| binding | 2.83465364476231 | bayes_pls_golite062009 |
| transcription regulator activity | 2.10110937001387 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.9581702424972 | bayes_pls_golite062009 |
| DNA replication origin binding | 1.84819558112187 | bayes_pls_golite062009 |
| translation regulator activity | 1.46320772716954 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 1.40718318783582 | bayes_pls_golite062009 |
| transcription repressor activity | 1.30343463892105 | bayes_pls_golite062009 |
| translation initiation factor activity | 1.27539679024898 | bayes_pls_golite062009 |
| transcription activator activity | 1.24141936405635 | bayes_pls_golite062009 |
| protein binding | 1.20309946451799 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
| transcription factor activity | 1.14242112812892 | bayes_pls_golite062009 |
| DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
| nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
| aminoacyl-tRNA ligase activity | 0.474251377131502 | bayes_pls_golite062009 |
| ligase activity, forming carbon-oxygen bonds | 0.47336621289748 | bayes_pls_golite062009 |
| ligase activity, forming aminoacyl-tRNA and related compounds | 0.47336621289748 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.31769813397725 | bayes_pls_golite062009 |
| exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
| RNA binding | 0.18502033889261 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
| DEAD/H-box RNA helicase binding | 0.0627405398613412 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
| helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
|
Region A: Residues: [394-471] |
1 11 21 31 41 51
| | | | | |
1 GDELEVTGIY TNNYDGSLNT DQGFPVFATV IIANHVVVKD SKQVVQSLTD EDIATIQKLS 60
61 KDPRIVERVV ASMAPSIY
|
| Detection Method: | |
| Confidence: | 41.154902 |
| Match: | 1ny5A |
| Description: | Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [472-797] |
1 11 21 31 41 51
| | | | | |
1 GHDYIKRALA LALFGGESKN PGEKHKVRGD INLLICGDPG TAKSQFLKYT EKVAPRAVFT 60
61 TGQGASAVGL TAYVRRNPVS REWTLEAGAL VLADQGVCLI DEFDKMNDQD RTSIHEAMEQ 120
121 QSISISKAGI VTSLQARCTV IAAANPIGGR YDPSMTFSEN VNLSEPILSR FDVLCVVKDE 180
181 FDPMQDQQLA KFVVHSHMKH HPSEEEQPEL EEPQLKTVDE IPQDLLRQYI VYAKENIRPK 240
241 LTNIDEDKIA KMYAQLRQES FATGSLPITV RHIESVIRMS EAHARMHLRE NVMEADVSMA 300
301 IRMMLESFIE AQKFSVMKKM RSTFQK
|
| Detection Method: | |
| Confidence: | 31.69897 |
| Match: | 2r44A |
| Description: | No description for 2r44A was found. |
|
Region A: Residues: [798-887] |
1 11 21 31 41 51
| | | | | |
1 YLSFQKDHSE LLFFILRQLT LDQLAYIRCK DGPGATHVEI MERDLIERAK QLDIVNLKPF 60
61 YESDLFRTNG FSYDPKRRII LQIVVDGNTA
|
| Detection Method: | |
| Confidence: | 6.39794 |
| Match: | 1ntcA |
| Description: | DNA-binding domain of NTRC |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 5.13863038737912 | bayes_pls_golite062009 |
| DNA binding | 4.66369707598026 | bayes_pls_golite062009 |
| nucleic acid binding | 4.51452285155271 | bayes_pls_golite062009 |
| transcription factor activity | 4.06706589695599 | bayes_pls_golite062009 |
| transcription repressor activity | 3.55154985983449 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 3.5139760613123 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 3.20235632037554 | bayes_pls_golite062009 |
| transcription activator activity | 3.10621734076555 | bayes_pls_golite062009 |
| binding | 3.02779747447702 | bayes_pls_golite062009 |
| telomeric DNA binding | 2.58260058025381 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.26183812259792 | bayes_pls_golite062009 |
| protein binding | 1.88087411289001 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.49423102874486 | bayes_pls_golite062009 |
| transcription factor binding | 1.40653841901929 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 1.40149699217445 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 1.40149699217445 | bayes_pls_golite062009 |
| protein deacetylase activity | 1.23680480131205 | bayes_pls_golite062009 |
| histone deacetylase activity | 1.18932416576802 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 1.14886080629275 | bayes_pls_golite062009 |
| chromatin binding | 1.04132983826241 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.84983974758882 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.666799964992178 | bayes_pls_golite062009 |
| histone binding | 0.557787598121402 | bayes_pls_golite062009 |
| deacetylase activity | 0.530687254192222 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.2679415219517 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.236060274498333 | bayes_pls_golite062009 |
| N-acyltransferase activity | 0.212884313176726 | bayes_pls_golite062009 |
| DNA helicase activity | 0.187022204923867 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity, enhancer binding | 0.13444271681002 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.105174598157041 | bayes_pls_golite062009 |
