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Protein Overview: FK506-bp2-PA

General Information:
Name(s) found: FK506-bp2-PA / FBpp0085703 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene FK506-binding protein 2 is referred to in FlyBase by the symbol Dmel\FK506-bp2 (CG11001, FBgn0013954). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15177610..15178467. It has the cytological map location 56C8. Based on sequence similarity, it is predicted to have molecular function</span>: FK506 binding; peptidyl-prolyl cis-trans isomerase activity. There is experimental evidence that it is involved in the biological process</span>: cellular response to DNA damage stimulus. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 108 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISS][NAS]
    Biological Process: protein folding [ISS][NAS]
    response to DNA damage stimulus [IMP]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [ISS][NAS]
    FK506 binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVQVVPIAP GDGSTYPKNG QKVTVHYTGT LDDGTKFDSS RDRNKPFKFT IGKGEVIRGW  60
   61 DEGVAQLSVG QRAKLICSPD YAYGSRGHPG VIPPNSTLTF DVELLKVE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 34.69897 ATOMIC STRUCTURE OF FKBP12, AN IMMUNOPHILIN BINDING PROTEIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ryanodine-sensitive calcium-release channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • macrolide binding
    		•  7.31599503004442 bayes_pls_golite062009
  • FK506 binding
    		•  7.22442625476031 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
    		•  6.4374377859142 bayes_pls_golite062009
  • cation channel activity
    		•  6.06732269872248 bayes_pls_golite062009
  • ion channel activity
    		•  5.45007096522107 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.32426176964634 bayes_pls_golite062009
  • channel activity
    		•  5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.28960420749143 bayes_pls_golite062009
  • gated channel activity
    		•  5.28074654906904 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.85589011277711 bayes_pls_golite062009
  • receptor activity
    		•  1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68688812199737 bayes_pls_golite062009
  • kinase activity
    		•  1.67904764195462 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57898291235576 bayes_pls_golite062009
  • signal transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • protein kinase activity
    		•  1.45320632553313 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • transferase activity
    		•  1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.32709321745178 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • protein binding
    		•  1.08765413491791 bayes_pls_golite062009
  • SMAD binding
    		•  1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.780499202755666 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.763739321802433 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • activin binding
    		•  0.33489895389042 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • histone binding
    		•  0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.21145105012677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle