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Protein Overview: Dcr-2-PA

General Information:
Name(s) found: Dcr-2-PA / FBpp0086061 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Dicer-2 is referred to in FlyBase by the symbol Dmel\Dcr-2 (CG6493, FBgn0034246). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13462484..13469011. It has the cytological map location 54C10. Based on sequence similarity, it is predicted to have molecular function</span>: double-stranded RNA binding; helicase activity. There is experimental evidence that it is involved in the biological process</span>: siRNA loading onto RISC involved in RNA interference; RNA interference; dsRNA transport; production of siRNA involved in RNA interference; targeting of mRNA for destruction involved in RNA interference; defense response to virus; chromatin silencing. 26 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1722 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    Biological Process: siRNA loading onto RISC involved in RNA interference [IMP]
    defense response to virus [IMP]
    chromatin silencing [IMP]
    production of siRNA involved in RNA interference [IDA][IMP][TAS]
    RNA interference [IDA][IMP][NAS][TAS]
    dsRNA transport [IMP]
    targeting of mRNA for destruction involved in RNA interference [IMP]
    Molecular Function: ATP binding [IEA]
    ribonuclease III activity [IEA]
    double-stranded RNA binding [IEA][ISS][NAS]
    ATP-dependent helicase activity [IEA]
    helicase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDVEIKPRG YQLRLVDHLT KSNGIVYLPT GSGKTFVAIL VLKRFSQDFD KPIESGGKRA  60
   61 LFMCNTVELA RQQAMAVRRC TNFKVGFYVG EQGVDDWTRG MWSDEIKKNQ VLVGTAQVFL 120
  121 DMVTQTYVAL SSLSVVIIDE CHHGTGHHPF REFMRLFTIA NQTKLPRVVG LTGVLIKGNE 180
  181 ITNVATKLKE LEITYRGNII TVSDTKEMEN VMLYATKPTE VMVSFPHQEQ VLTVTRLISA 240
  241 EIEKFYVSLD LMNIGVQPIR RSKSLQCLRD PSKKSFVKQL FNDFLYQMKE YGIYAASIAI 300
  301 ISLIVEFDIK RRQAETLSVK LMHRTALTLC EKIRHLLVQK LQDMTYDDDD DNVNTEEVIM 360
  361 NFSTPKVQRF LMSLKVSFAD KDPKDICCLV FVERRYTCKC IYGLLLNYIQ STPELRNVLT 420
  421 PQFMVGRNNI SPDFESVLER KWQKSAIQQF RDGNANLMIC SSVLEEGIDV QACNHVFILD 480
  481 PVKTFNMYVQ SKGRARTTEA KFVLFTADKE REKTIQQIYQ YRKAHNDIAE YLKDRVLEKT 540
  541 EPELYEIKGH FQDDIDPFTN ENGAVLLPNN ALAILHRYCQ TIPTDAFGFV IPWFHVLQED 600
  601 ERDRIFGVSA KGKHVISINM PVNCMLRDTI YSDPMDNVKT AKISAAFKAC KVLYSLGELN 660
  661 ERFVPKTLKE RVASIADVHF EHWNKYGDSV TATVNKADKS KDRTYKTECP LEFYDALPRV 720
  721 GEICYAYEIF LEPQFESCEY TEHMYLNLQT PRNYAILLRN KLPRLAEMPL FSNQGKLHVR 780
  781 VANAPLEVII QNSEQLELLH QFHGMVFRDI LKIWHPFFVL DRRSKENSYL VVPLILGAGE 840
  841 QKCFDWELMT NFRRLPQSHG SNVQQREQQP APRPEDFEGK IVTQWYANYD KPMLVTKVHR 900
  901 ELTPLSYMEK NQQDKTYYEF TMSKYGNRIG DVVHKDKFMI EVRDLTEQLT FYVHNRGKFN 960
  961 AKSKAKMKVI LIPELCFNFN FPGDLWLKLI FLPSILNRMY FLLHAEALRK RFNTYLNLHL1020
 1021 LPFNGTDYMP RPLEIDYSLK RNVDPLGNVI PTEDIEEPKS LLEPMPTKSI EASVANLEIT1080
 1081 EFENPWQKYM EPVDLSRNLL STYPVELDYY YHFSVGNVCE MNEMDFEDKE YWAKNQFHMP1140
 1141 TGNIYGNRTP AKTNANVPAL MPSKPTVRGK VKPLLILQKT VSKEHITPAE QGEFLAAITA1200
 1201 SSAADVFDME RLEILGDSFL KLSATLYLAS KYSDWNEGTL TEVKSKLVSN RNLLFCLIDA1260
 1261 DIPKTLNTIQ FTPRYTWLPP GISLPHNVLA LWRENPEFAK IIGPHNLRDL ALGDEESLVK1320
 1321 GNCSDINYNR FVEGCRANGQ SFYAGADFSS EVNFCVGLVT IPNKVIADTL EALLGVIVKN1380
 1381 YGLQHAFKML EYFKICRADI DKPLTQLLNL ELGGKKMRAN VNTTEIDGFL INHYYLEKNL1440
 1441 GYTFKDRRYL LQALTHPSYP TNRITGSYQE LEFIGDAILD FLISAYIFEN NTKMNPGALT1500
 1501 DLRSALVNNT TLACICVRHR LHFFILAENA KLSEIISKFV NFQESQGHRV TNYVRILLEE1560
 1561 ADVQPTPLDL DDELDMTELP HANKCISQEA EKGVPPKGEF NMSTNVDVPK ALGDVLEALI1620
 1621 AAVYLDCRDL QRTWEVIFNL FEPELQEFTR KVPINHIRQL VEHKHAKPVF SSPIVEGETV1680
 1681 MVSCQFTCME KTIKVYGFGS NKDQAKLSAA KHALQQLSKC DA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..361] PSI-BLAST 85.0 No description for 2i4iA was found.
    2 View Details [362..609] PSI-BLAST 19.69897 Initiation factor 4a
    3 View Details [610..696] deduced N/A No confident structure predictions are available.
    4 View Details [697..1174] FFAS03 3.88 Crystal structure of full length Argonaute from Pyrococcus furiosus
    5 View Details [1175..1336] PSI-BLAST 12.0 Crystal Structure of Dicer from Giardia intestinalis
    6 View Details [1337..1420] deduced N/A No confident structure predictions are available.
    7 View Details [1421..1722] PSI-BLAST 44.045757 RNase III endonuclease catalytic domain; RNase III, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nucleoside-triphosphatase activity
    		•  2.85628130885095 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.78950165917982 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.76996223962376 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.7670079419026 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • transporter activity
    		•  2.36978240084485 bayes_pls_golite062009
  • ATPase activity
    		•  2.26864012421561 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.18065576425044 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.07184330056272 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.8459294302596 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.68112322593144 bayes_pls_golite062009
  • RNA binding
    		•  1.60613159109369 bayes_pls_golite062009
  • hydrolase activity
    		•  1.44476395406467 bayes_pls_golite062009
    		• 1.44426272235796 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.09373202836575 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.74918137191219 bayes_pls_golite062009
  • structural molecule activity
    		•  0.70126232242991 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.696000326143746 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.69117331267457 bayes_pls_golite062009
  • GTPase activity
    		•  0.564061217246417 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.140475613064199 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0869561319004262 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • signal sequence binding
    		•  6.53725193420218E-4 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • miRNA binding
    		•  6.3992603035571 bayes_pls_golite062009
  • siRNA binding
    		•  3.79765075105166 bayes_pls_golite062009
  • RNA binding
    		•  3.38840041033834 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.6547106391215 bayes_pls_golite062009
  • binding
    		•  2.47643238059712 bayes_pls_golite062009
  • protein binding
    		•  1.26667637732731 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.291763447649747 bayes_pls_golite062009
  • catalytic activity
    		•  0.290929394811364 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • bidentate ribonuclease III activity
    		•  7.43273509253496 bayes_pls_golite062009
  • RNA binding
    		•  5.07736605479017 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.05567898179605 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  3.47197996469543 bayes_pls_golite062009
  • binding
    		•  3.29553298371996 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.02689668760645 bayes_pls_golite062009
  • siRNA binding
    		•  2.97216972787792 bayes_pls_golite062009
  • DNA binding
    		•  2.51691938562322 bayes_pls_golite062009
  • structural molecule activity
    		•  2.49813032879923 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36373437225982 bayes_pls_golite062009
  • ribonuclease III activity
    		•  2.17541496872253 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.81658786565141 bayes_pls_golite062009
  • endoribonuclease activity
    		•  1.62086478301433 bayes_pls_golite062009
  • protein binding
    		•  1.43319050998069 bayes_pls_golite062009
  • transcription factor activity
    		•  1.26788594164029 bayes_pls_golite062009
  • transcription activator activity
    		•  0.434769929118334 bayes_pls_golite062009
  • mRNA binding
    		•  0.404665180963566 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.35650576095599 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0407924801791524 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0126548515995795 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.0112094156505713 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.00332337214730594 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  9.75560608640569E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle