| Protein: | Dcr-2-PA |
| Organism: | Drosophila melanogaster |
| Length: | 1722 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dcr-2-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
1340.0 | [0..8] | [1722..1] |
|
Region A: Residues: [1-361] |
1 11 21 31 41 51
| | | | | |
1 MEDVEIKPRG YQLRLVDHLT KSNGIVYLPT GSGKTFVAIL VLKRFSQDFD KPIESGGKRA 60
61 LFMCNTVELA RQQAMAVRRC TNFKVGFYVG EQGVDDWTRG MWSDEIKKNQ VLVGTAQVFL 120
121 DMVTQTYVAL SSLSVVIIDE CHHGTGHHPF REFMRLFTIA NQTKLPRVVG LTGVLIKGNE 180
181 ITNVATKLKE LEITYRGNII TVSDTKEMEN VMLYATKPTE VMVSFPHQEQ VLTVTRLISA 240
241 EIEKFYVSLD LMNIGVQPIR RSKSLQCLRD PSKKSFVKQL FNDFLYQMKE YGIYAASIAI 300
301 ISLIVEFDIK RRQAETLSVK LMHRTALTLC EKIRHLLVQK LQDMTYDDDD DNVNTEEVIM 360
361 N
|
| Detection Method: |  |
| Confidence: | 85.0 |
| Match: | 2i4iA |
| Description: | No description for 2i4iA was found. |
|
Region A: Residues: [362-609] |
1 11 21 31 41 51
| | | | | |
1 FSTPKVQRFL MSLKVSFADK DPKDICCLVF VERRYTCKCI YGLLLNYIQS TPELRNVLTP 60
61 QFMVGRNNIS PDFESVLERK WQKSAIQQFR DGNANLMICS SVLEEGIDVQ ACNHVFILDP 120
121 VKTFNMYVQS KGRARTTEAK FVLFTADKER EKTIQQIYQY RKAHNDIAEY LKDRVLEKTE 180
181 PELYEIKGHF QDDIDPFTNE NGAVLLPNNA LAILHRYCQT IPTDAFGFVI PWFHVLQEDE 240
241 RDRIFGVS
|
| Detection Method: | |
| Confidence: | 19.69897 |
| Match: | 1fukA |
| Description: | Initiation factor 4a |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| nucleoside-triphosphatase activity | 2.85628130885095 | bayes_pls_golite062009 |
| pyrophosphatase activity | 2.78950165917982 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 2.76996223962376 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 2.7670079419026 | bayes_pls_golite062009 |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| nucleic acid binding | 2.51683451033161 | bayes_pls_golite062009 |
| transporter activity | 2.36978240084485 | bayes_pls_golite062009 |
| ATPase activity | 2.26864012421561 | bayes_pls_golite062009 |
| transmembrane transporter activity | 2.18065576425044 | bayes_pls_golite062009 |
| DNA binding | 2.12258000781149 | bayes_pls_golite062009 |
| transcription regulator activity | 2.09345198747025 | bayes_pls_golite062009 |
| ATPase activity, coupled | 2.07184330056272 | bayes_pls_golite062009 |
| RNA helicase activity | 1.8459294302596 | bayes_pls_golite062009 |
| structural constituent of ribosome | 1.68112322593144 | bayes_pls_golite062009 |
| RNA binding | 1.60613159109369 | bayes_pls_golite062009 |
| hydrolase activity | 1.44476395406467 | bayes_pls_golite062009 |
| 1.44426272235796 | bayes_pls_golite062009 | |
| substrate-specific transporter activity | 1.09373202836575 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.929901285538132 | bayes_pls_golite062009 |
| nucleotide binding | 0.922442819194247 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.920987930180051 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.920926158369519 | bayes_pls_golite062009 |
| transcription factor activity | 0.887108427603557 | bayes_pls_golite062009 |
| transcription repressor activity | 0.862685397469217 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.74918137191219 | bayes_pls_golite062009 |
| structural molecule activity | 0.70126232242991 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.696000326143746 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.69117331267457 | bayes_pls_golite062009 |
| GTPase activity | 0.564061217246417 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.434775387083003 | bayes_pls_golite062009 |
| ATP binding | 0.41092997612902 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 0.385813421701492 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 0.377870145186619 | bayes_pls_golite062009 |
| guanyl nucleotide binding | 0.296406132096546 | bayes_pls_golite062009 |
| GTP binding | 0.295705904888768 | bayes_pls_golite062009 |
| primary active transmembrane transporter activity | 0.294474570607914 | bayes_pls_golite062009 |
| guanyl ribonucleotide binding | 0.29028316917561 | bayes_pls_golite062009 |
| P-P-bond-hydrolysis-driven transmembrane transporter activity | 0.282352478532746 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | 0.220608508617331 | bayes_pls_golite062009 |
| ATPase activity, coupled to transmembrane movement of substances | 0.219533217661421 | bayes_pls_golite062009 |
| ATPase activity, coupled to movement of substances | 0.219157471322311 | bayes_pls_golite062009 |
| protein binding | 0.170837278876362 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.140475613064199 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.0869561319004262 | bayes_pls_golite062009 |
| helicase activity | 0.0775311459068899 | bayes_pls_golite062009 |
| signal sequence binding | 6.53725193420218E-4 | bayes_pls_golite062009 |
|
Region A: Residues: [610-696] |
1 11 21 31 41 51
| | | | | |
1 AKGKHVISIN MPVNCMLRDT IYSDPMDNVK TAKISAAFKA CKVLYSLGEL NERFVPKTLK 60
61 ERVASIADVH FEHWNKYGDS VTATVNK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [697-1174] |
1 11 21 31 41 51
| | | | | |
1 ADKSKDRTYK TECPLEFYDA LPRVGEICYA YEIFLEPQFE SCEYTEHMYL NLQTPRNYAI 60
61 LLRNKLPRLA EMPLFSNQGK LHVRVANAPL EVIIQNSEQL ELLHQFHGMV FRDILKIWHP 120
121 FFVLDRRSKE NSYLVVPLIL GAGEQKCFDW ELMTNFRRLP QSHGSNVQQR EQQPAPRPED 180
181 FEGKIVTQWY ANYDKPMLVT KVHRELTPLS YMEKNQQDKT YYEFTMSKYG NRIGDVVHKD 240
241 KFMIEVRDLT EQLTFYVHNR GKFNAKSKAK MKVILIPELC FNFNFPGDLW LKLIFLPSIL 300
301 NRMYFLLHAE ALRKRFNTYL NLHLLPFNGT DYMPRPLEID YSLKRNVDPL GNVIPTEDIE 360
361 EPKSLLEPMP TKSIEASVAN LEITEFENPW QKYMEPVDLS RNLLSTYPVE LDYYYHFSVG 420
421 NVCEMNEMDF EDKEYWAKNQ FHMPTGNIYG NRTPAKTNAN VPALMPSKPT VRGKVKPL
|
| Detection Method: | |
| Confidence: | 3.88 |
| Match: | 1u04A |
| Description: | Crystal structure of full length Argonaute from Pyrococcus furiosus |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| miRNA binding | 6.3992603035571 | bayes_pls_golite062009 |
| siRNA binding | 3.79765075105166 | bayes_pls_golite062009 |
| RNA binding | 3.38840041033834 | bayes_pls_golite062009 |
| nucleic acid binding | 2.6547106391215 | bayes_pls_golite062009 |
| binding | 2.47643238059712 | bayes_pls_golite062009 |
| protein binding | 1.26667637732731 | bayes_pls_golite062009 |
| translation initiation factor activity | 0.291763447649747 | bayes_pls_golite062009 |
| catalytic activity | 0.290929394811364 | bayes_pls_golite062009 |
|
Region A: Residues: [1175-1336] |
1 11 21 31 41 51
| | | | | |
1 LILQKTVSKE HITPAEQGEF LAAITASSAA DVFDMERLEI LGDSFLKLSA TLYLASKYSD 60
61 WNEGTLTEVK SKLVSNRNLL FCLIDADIPK TLNTIQFTPR YTWLPPGISL PHNVLALWRE 120
121 NPEFAKIIGP HNLRDLALGD EESLVKGNCS DINYNRFVEG CR
|
| Detection Method: | |
| Confidence: | 12.0 |
| Match: | 2fflA |
| Description: | Crystal Structure of Dicer from Giardia intestinalis |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1337-1420] |
1 11 21 31 41 51
| | | | | |
1 ANGQSFYAGA DFSSEVNFCV GLVTIPNKVI ADTLEALLGV IVKNYGLQHA FKMLEYFKIC 60
61 RADIDKPLTQ LLNLELGGKK MRAN
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1421-1722] |
1 11 21 31 41 51
| | | | | |
1 VNTTEIDGFL INHYYLEKNL GYTFKDRRYL LQALTHPSYP TNRITGSYQE LEFIGDAILD 60
61 FLISAYIFEN NTKMNPGALT DLRSALVNNT TLACICVRHR LHFFILAENA KLSEIISKFV 120
121 NFQESQGHRV TNYVRILLEE ADVQPTPLDL DDELDMTELP HANKCISQEA EKGVPPKGEF 180
181 NMSTNVDVPK ALGDVLEALI AAVYLDCRDL QRTWEVIFNL FEPELQEFTR KVPINHIRQL 240
241 VEHKHAKPVF SSPIVEGETV MVSCQFTCME KTIKVYGFGS NKDQAKLSAA KHALQQLSKC 300
301 DA
|
| Detection Method: | |
| Confidence: | 44.045757 |
| Match: | 1o0wA |
| Description: | RNase III endonuclease catalytic domain; RNase III, C-terminal domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| bidentate ribonuclease III activity | 7.43273509253496 | bayes_pls_golite062009 |
| RNA binding | 5.07736605479017 | bayes_pls_golite062009 |
| nucleic acid binding | 4.05567898179605 | bayes_pls_golite062009 |
| double-stranded RNA binding | 3.47197996469543 | bayes_pls_golite062009 |
| binding | 3.29553298371996 | bayes_pls_golite062009 |
| structural constituent of ribosome | 3.02689668760645 | bayes_pls_golite062009 |
| siRNA binding | 2.97216972787792 | bayes_pls_golite062009 |
| DNA binding | 2.51691938562322 | bayes_pls_golite062009 |
| structural molecule activity | 2.49813032879923 | bayes_pls_golite062009 |
| transcription regulator activity | 2.36373437225982 | bayes_pls_golite062009 |
| ribonuclease III activity | 2.17541496872253 | bayes_pls_golite062009 |
| transcription repressor activity | 1.81658786565141 | bayes_pls_golite062009 |
| endoribonuclease activity | 1.62086478301433 | bayes_pls_golite062009 |
| protein binding | 1.43319050998069 | bayes_pls_golite062009 |
| transcription factor activity | 1.26788594164029 | bayes_pls_golite062009 |
| transcription activator activity | 0.434769929118334 | bayes_pls_golite062009 |
| mRNA binding | 0.404665180963566 | bayes_pls_golite062009 |
| single-stranded RNA binding | 0.35650576095599 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0407924801791524 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.0126548515995795 | bayes_pls_golite062009 |
| RNA helicase activity | 0.0112094156505713 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.00332337214730594 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 9.75560608640569E-4 | bayes_pls_golite062009 |
