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Protein Overview: Khc-73-PA

General Information:
Name(s) found: Khc-73-PA / FBpp0086490 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Kinesin-73 is referred to in FlyBase by the symbol Dmel\Khc-73 (CG8183, FBgn0019968). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11403283..11419743. It has the cytological map location 52A6-52A10. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule motor activity; microtubule binding. There is experimental evidence that it is involved in the biological process</span>: establishment of spindle orientation. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1921 amino acids

    Gene Ontology:
    Cellular Component: kinesin complex [ISS]
    astral microtubule [IDA]
    Biological Process: establishment of spindle orientation [IMP]
    microtubule-based movement [ISS]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [ISS]
    microtubule binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASDKIKVAV RVRPFNRREI ELDTKCIVEM EKQQTILQNP PPLEKIERKQ PKTFAFDHCF  60
   61 YSLNPEDENF ASQETVFDCV GRGILDNAFQ GYNACIFAYG QTGSGKSYTM MGTQESKGII 120
  121 PRLCDQLFSA IANKSTPELM YKVEVSYMEI YNEKVHDLLD PKPNKQSLKV REHNVMGPYV 180
  181 DGLSQLAVTS YQDIDNLMTE GNKSRTVAAT NMNAESSRSH AVFSVVLTQI LTDQATGVSG 240
  241 EKVSRMSLVD LAGSERAVKT GAVGDRLKEG SNINKSLTTL GLVISKLADQ SNGKKSGNDK 300
  301 FVPYRDSVLT WLLKDNLGGN SRTVMVATIS PSADNYEETL STLRYADRAK RIVNHAVVNE 360
  361 DPNARIIREL RHEVETLRSM LKHATGSPVG DVQDKLAESE NLMKQISQTW EEKLVKTERI 420
  421 QNERQQALEK MGISVQASGI KVEKNKYYLV NLNADPSLNE LLVYYLKDRT LIGGRTISGQ 480
  481 QPDIQLSGLG IQPEHCVITI EDSGLYMEPV QGARCFVNGS AAVEKTPLQN GDRILWGNHH 540
  541 FFRVNSPKSN NTSMCASEPQ TPAQLIDYNF ARDEIMQNEL SNDPIQTAIA RLERQHEEDK 600
  601 QVALEKQRQE YERQFQQLRN ILSPSTPYAP YAPYDPLRMG KITPNTPTSQ MRVEKWAQER 660
  661 DEMFRRSLGQ LKTDIMRANS LVQEANFLAE EMEKKTKFSV TLQIPPANLS PNRRRGAFVS 720
  721 EPAILVKRTN SGSQIWTMEK LENKLIDMRE MYQEHKERVL NGLPLIEPFS EDEFDDKDED 780
  781 NAKPQDPFYE SQENHNLIGV ANIFLEVLFH DVKLDYHTPI ISQQGEVAGR LQVEIERIAG 840
  841 QMPQDRMCES VSESSGDSRD EYDDPVDPTS NQITCRVTIK CASGLPLSLS NFVFCQYTFW 900
  901 GHQEMVVPVI NAESTAHDQN MVFKFEHTQD FTVTINEEFL EHCIEGALSI EVWGHRSAGF 960
  961 SKTKGWEVEQ QQAKARSLVD RWAELSRKIE LWVEIHELND NGEYSPVEVT NRNEVLTGGI1020
 1021 YQLRQGQQRR VNVRVKPVQN SGTLPIICQS IVNVAIGSVT VRSRLQRPLD SYQEEDLTVL1080
 1081 REKWSEALGR RRQYLDQQIQ MLIKKEEKNE QERERELSLV HQWVSLTEER NAVLVPAPGS1140
 1141 GIPGAPASWE PPSGMEPHVP VLFLNLNGDD LSAQNTNDEL SVAGINSILS KEHGHKFYTL1200
 1201 QILQHLDKDV CCVASWDSSM HDSQALNRVT EANERVYLIL RTTVRLSHPA PMDLVLRKRL1260
 1261 SINIKKGQTL TDRLKKFRLV RGENAIWQSG VTYEVVSNIP KASEELEDRE SLAQLAASGD1320
 1321 DCSASDGETY IEKYTRGVSA VESILTLDRL RQNVAVKELE TAHGQPLSMR KTVSVPNFSQ1380
 1381 QLINKLTQIM RFDASMESLL NVGRSESFAD LNNSALGNKF TPAGHSPAGA GGVIRSRHSF1440
 1441 GGKGSSDDSP GKAFGIASPA TSKLLGMRMT TLHEEPLGGH RSLDEEPEDS YSDSEYAAEY1500
 1501 EQERQQNKSM ATRSRLTASK TMDSFMDVSS HSNQSYLSYT SSANANMKHL TGLATLSMSS1560
 1561 STSSGYGSQA VSCNNLSNED IASMRSMSID ETPDFDRVNS NSPPNRQARV NPFLKDMPKA1620
 1621 KIQEQPEQQA KKLQEAFTHP LEQLESSQNA QSDDDECAQL PKNNNNNLDL VNEPKPLSSQ1680
 1681 TDLEESMSQP KSKTEFATDN QNGNRSSDEL SHSSEDLLEG DGIVREELPA GKVVRRKKSN1740
 1741 TQPPSNGNSI NNNNNGTTQA PRINHRASVA KMEGLAAYLD SSIMTSSTEV DEESKDVELV1800
 1801 LPEWIVVGES VLIRPYNTSG VIRFVGTTEF QPGAWIGVEL DTPTGKNDGS VKGVQYFQCK1860
 1861 PKHGMFVRSD KLMLDKRGKA MRAYKAAEKS NSISKEMSTS MTGSMTRSKS RGDSLNLSAR1920
 1921 K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..301] PSI-BLAST 118.0 Kinesin
    2 View Details [302..1147] PSI-BLAST 14.69897 Heavy meromyosin subfragment
    3 View Details [1148..1267] MSA 1.149994 View MSA. No confident structure predictions are available.
    4 View Details [1268..1476] deduced N/A No confident structure predictions are available.
    5 View Details [1477..1704] MSA 3.331996 View MSA. No confident structure predictions are available.
    6 View Details [1705..1921] PSI-BLAST 11.09691 Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.07967285635739 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.579644950922817 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.17029946873911 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13866566261611 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • microtubule plus-end binding
    		•  8.0471848994845 bayes_pls_golite062009
  • microtubule motor activity
    		•  7.89745047899796 bayes_pls_golite062009
  • tubulin binding
    		•  7.03615802330765 bayes_pls_golite062009
  • microtubule binding
    		•  6.8896345230761 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  5.6767661132061 bayes_pls_golite062009
  • motor activity
    		•  3.58626738774504 bayes_pls_golite062009
  • binding
    		•  2.67147900161276 bayes_pls_golite062009
  • protein binding
    		•  2.6431546546327 bayes_pls_golite062009
  • actin binding
    		•  1.93456226222672 bayes_pls_golite062009
  • dynein binding
    		•  1.86483077354148 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.682706145156405 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.501988604100708 bayes_pls_golite062009
  • DNA binding
    		•  0.474802480998286 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.272404679751888 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.227204879992381 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.216109557610252 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.213569745388334 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0484338426456319 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle