| Protein: | Khc-73-PA |
| Organism: | Drosophila melanogaster |
| Length: | 1921 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Khc-73-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
1218.0 | [0..1] | [1921..1] |
|
Region A: Residues: [1-301] |
1 11 21 31 41 51
| | | | | |
1 MASDKIKVAV RVRPFNRREI ELDTKCIVEM EKQQTILQNP PPLEKIERKQ PKTFAFDHCF 60
61 YSLNPEDENF ASQETVFDCV GRGILDNAFQ GYNACIFAYG QTGSGKSYTM MGTQESKGII 120
121 PRLCDQLFSA IANKSTPELM YKVEVSYMEI YNEKVHDLLD PKPNKQSLKV REHNVMGPYV 180
181 DGLSQLAVTS YQDIDNLMTE GNKSRTVAAT NMNAESSRSH AVFSVVLTQI LTDQATGVSG 240
241 EKVSRMSLVD LAGSERAVKT GAVGDRLKEG SNINKSLTTL GLVISKLADQ SNGKKSGNDK 300
301 F
|
| Detection Method: |  |
| Confidence: | 118.0 |
| Match: | 1i6iA |
| Description: | Kinesin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| microtubule motor activity | 7.68336791348661 | bayes_pls_golite062009 |
| plus-end-directed microtubule motor activity | 4.97507344344589 | bayes_pls_golite062009 |
| microfilament motor activity | 4.176620576177 | bayes_pls_golite062009 |
| motor activity | 4.04927796049806 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 2.95079405147356 | bayes_pls_golite062009 |
| pyrophosphatase activity | 2.87427509025394 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 2.85499564954033 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 2.85178667290149 | bayes_pls_golite062009 |
| actin-dependent ATPase activity | 2.77140616759165 | bayes_pls_golite062009 |
| microtubule plus-end binding | 2.71138928021716 | bayes_pls_golite062009 |
| tubulin binding | 2.67743463093593 | bayes_pls_golite062009 |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| microtubule binding | 2.59155206524122 | bayes_pls_golite062009 |
| transporter activity | 2.58140740499725 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.4101693596493 | bayes_pls_golite062009 |
| transmembrane transporter activity | 2.39695871109024 | bayes_pls_golite062009 |
| ATPase activity | 2.39535714892224 | bayes_pls_golite062009 |
| ATPase activity, coupled | 2.18396165590908 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 2.07967285635739 | bayes_pls_golite062009 |
| actin binding | 1.75397031486306 | bayes_pls_golite062009 |
| hydrolase activity | 1.57549510726226 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.40384549325664 | bayes_pls_golite062009 |
| helicase activity | 1.33212695797068 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 1.29730375126024 | bayes_pls_golite062009 |
| protein binding | 1.22129154759482 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 1.07479235523606 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.929901285538132 | bayes_pls_golite062009 |
| nucleotide binding | 0.922442819194247 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.920987930180051 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.920926158369519 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.906554174337376 | bayes_pls_golite062009 |
| nucleic acid binding | 0.777787753097919 | bayes_pls_golite062009 |
| actin filament binding | 0.728264616959762 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.579644950922817 | bayes_pls_golite062009 |
| kinetochore binding | 0.505370954958131 | bayes_pls_golite062009 |
| DNA binding | 0.479412476059825 | bayes_pls_golite062009 |
| GTPase activity | 0.437665353870877 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.434775387083003 | bayes_pls_golite062009 |
| ATP binding | 0.41092997612902 | bayes_pls_golite062009 |
| guanyl nucleotide binding | 0.399434758448606 | bayes_pls_golite062009 |
| GTP binding | 0.398333597279278 | bayes_pls_golite062009 |
| guanyl ribonucleotide binding | 0.39332178627529 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 0.385813421701492 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 0.377870145186619 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.355466224802969 | bayes_pls_golite062009 |
| RNA helicase activity | 0.34746349346164 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 0.328186246219424 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 0.328186246219424 | bayes_pls_golite062009 |
| transcription regulator activity | 0.312171320541728 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.30832907234141 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.29532978396745 | bayes_pls_golite062009 |
| primary active transmembrane transporter activity | 0.294474570607914 | bayes_pls_golite062009 |
| P-P-bond-hydrolysis-driven transmembrane transporter activity | 0.282352478532746 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 0.25143870859482 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 0.25143870859482 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | 0.220608508617331 | bayes_pls_golite062009 |
| ATPase activity, coupled to transmembrane movement of substances | 0.219533217661421 | bayes_pls_golite062009 |
| ATPase activity, coupled to movement of substances | 0.219157471322311 | bayes_pls_golite062009 |
| protein transporter activity | 0.178442534411253 | bayes_pls_golite062009 |
| DNA helicase activity | 0.17029946873911 | bayes_pls_golite062009 |
| mismatched DNA binding | 0.13866566261611 | bayes_pls_golite062009 |
| minus-end-directed microtubule motor activity | 0.068779631341469 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 0.0254369227200564 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.0111338193708552 | bayes_pls_golite062009 |
|
Region A: Residues: [302-1147] |
1 11 21 31 41 51
| | | | | |
1 VPYRDSVLTW LLKDNLGGNS RTVMVATISP SADNYEETLS TLRYADRAKR IVNHAVVNED 60
61 PNARIIRELR HEVETLRSML KHATGSPVGD VQDKLAESEN LMKQISQTWE EKLVKTERIQ 120
121 NERQQALEKM GISVQASGIK VEKNKYYLVN LNADPSLNEL LVYYLKDRTL IGGRTISGQQ 180
181 PDIQLSGLGI QPEHCVITIE DSGLYMEPVQ GARCFVNGSA AVEKTPLQNG DRILWGNHHF 240
241 FRVNSPKSNN TSMCASEPQT PAQLIDYNFA RDEIMQNELS NDPIQTAIAR LERQHEEDKQ 300
301 VALEKQRQEY ERQFQQLRNI LSPSTPYAPY APYDPLRMGK ITPNTPTSQM RVEKWAQERD 360
361 EMFRRSLGQL KTDIMRANSL VQEANFLAEE MEKKTKFSVT LQIPPANLSP NRRRGAFVSE 420
421 PAILVKRTNS GSQIWTMEKL ENKLIDMREM YQEHKERVLN GLPLIEPFSE DEFDDKDEDN 480
481 AKPQDPFYES QENHNLIGVA NIFLEVLFHD VKLDYHTPII SQQGEVAGRL QVEIERIAGQ 540
541 MPQDRMCESV SESSGDSRDE YDDPVDPTSN QITCRVTIKC ASGLPLSLSN FVFCQYTFWG 600
601 HQEMVVPVIN AESTAHDQNM VFKFEHTQDF TVTINEEFLE HCIEGALSIE VWGHRSAGFS 660
661 KTKGWEVEQQ QAKARSLVDR WAELSRKIEL WVEIHELNDN GEYSPVEVTN RNEVLTGGIY 720
721 QLRQGQQRRV NVRVKPVQNS GTLPIICQSI VNVAIGSVTV RSRLQRPLDS YQEEDLTVLR 780
781 EKWSEALGRR RQYLDQQIQM LIKKEEKNEQ ERERELSLVH QWVSLTEERN AVLVPAPGSG 840
841 IPGAPA
|
| Detection Method: | |
| Confidence: | 14.69897 |
| Match: | 1i84S |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1148-1267] |
1 11 21 31 41 51
| | | | | |
1 SWEPPSGMEP HVPVLFLNLN GDDLSAQNTN DELSVAGINS ILSKEHGHKF YTLQILQHLD 60
61 KDVCCVASWD SSMHDSQALN RVTEANERVY LILRTTVRLS HPAPMDLVLR KRLSINIKKG 120
121
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1268-1476] |
1 11 21 31 41 51
| | | | | |
1 QTLTDRLKKF RLVRGENAIW QSGVTYEVVS NIPKASEELE DRESLAQLAA SGDDCSASDG 60
61 ETYIEKYTRG VSAVESILTL DRLRQNVAVK ELETAHGQPL SMRKTVSVPN FSQQLINKLT 120
121 QIMRFDASME SLLNVGRSES FADLNNSALG NKFTPAGHSP AGAGGVIRSR HSFGGKGSSD 180
181 DSPGKAFGIA SPATSKLLGM RMTTLHEEP
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1477-1704] |
1 11 21 31 41 51
| | | | | |
1 LGGHRSLDEE PEDSYSDSEY AAEYEQERQQ NKSMATRSRL TASKTMDSFM DVSSHSNQSY 60
61 LSYTSSANAN MKHLTGLATL SMSSSTSSGY GSQAVSCNNL SNEDIASMRS MSIDETPDFD 120
121 RVNSNSPPNR QARVNPFLKD MPKAKIQEQP EQQAKKLQEA FTHPLEQLES SQNAQSDDDE 180
181 CAQLPKNNNN NLDLVNEPKP LSSQTDLEES MSQPKSKTEF ATDNQNGN
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1705-1921] |
1 11 21 31 41 51
| | | | | |
1 RSSDELSHSS EDLLEGDGIV REELPAGKVV RRKKSNTQPP SNGNSINNNN NGTTQAPRIN 60
61 HRASVAKMEG LAAYLDSSIM TSSTEVDEES KDVELVLPEW IVVGESVLIR PYNTSGVIRF 120
121 VGTTEFQPGA WIGVELDTPT GKNDGSVKGV QYFQCKPKHG MFVRSDKLML DKRGKAMRAY 180
181 KAAEKSNSIS KEMSTSMTGS MTRSKSRGDS LNLSARK
|
| Detection Method: | |
| Confidence: | 11.09691 |
| Match: | 2cp6A |
| Description: | Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| microtubule plus-end binding | 8.0471848994845 | bayes_pls_golite062009 |
| microtubule motor activity | 7.89745047899796 | bayes_pls_golite062009 |
| tubulin binding | 7.03615802330765 | bayes_pls_golite062009 |
| microtubule binding | 6.8896345230761 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 5.6767661132061 | bayes_pls_golite062009 |
| motor activity | 3.58626738774504 | bayes_pls_golite062009 |
| binding | 2.67147900161276 | bayes_pls_golite062009 |
| protein binding | 2.6431546546327 | bayes_pls_golite062009 |
| actin binding | 1.93456226222672 | bayes_pls_golite062009 |
| dynein binding | 1.86483077354148 | bayes_pls_golite062009 |
| transcription regulator activity | 0.682706145156405 | bayes_pls_golite062009 |
| nucleic acid binding | 0.501988604100708 | bayes_pls_golite062009 |
| DNA binding | 0.474802480998286 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.272404679751888 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.227204879992381 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.216109557610252 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.213569745388334 | bayes_pls_golite062009 |
| transcription factor activity | 0.0484338426456319 | bayes_pls_golite062009 |
