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Protein Overview: Cyp6a23-PA

General Information:
Name(s) found: Cyp6a23-PA / FBpp0086582 [FlyBase]
Description(s) found:
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  • gi|24653737|ref|NP_611000.2| Cyp6a23 [Drosophila melanogaster] [NCBI NR]
  • gi|21627187|gb|AAF58189.2| Cyp6a23 [Drosophila melanogaster] [NCBI NR]
  • gi|202028041|gb|ACH95266.1| FI03292p [Drosophila melanogaster] [NCBI NR]
  • gi|11386700|sp|Q9V771.2|C6A23_DROME RecName: Full=Probable cytochrome P450 6a23; AltName: Full=CYPVIA23 [NCBI NR]
  • (Q9V771) Probable cytochrome P450 6a23 (EC 1.14.-.-) (CYPVIA23) [Swiss-Prot]
  • Probable cytochrome P450 6a23 OS=Drosophila melanogaster GN=Cyp6a23 PE=2 SV=2 [Swiss-Prot]
  • The gene Cyp6a23 is referred to in FlyBase by the symbol Dmel\Cyp6a23 (CG10242, FBgn0033978). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10763338..10765159. It has the cytological map location 51D1. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10242-PA translation from_gene[CG10242 Cyp6a23 FBgn0033978] seq_release:3 mol_weight=58090 cds_boundaries:(2R:9,939,587..9,941,157[+]) aa_length:502 transcript_info:[CG10242-RA seq_release:3] gene_info:[gene symbol:Cyp6a23 FBgn0033978 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • CG10242-PA [Drosophila melanogaster]gi|24653737|ref|NP_611000.2| CG10242-PA [Drosophila melanogaster]gi|11386700|sp|Q9V771|C6AN_DROME Probable cytochrome P450 6a23 (CYPVIA23) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(10763366..10764452,10764518..10764939); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189; MD5 [fly-100309-contam.fasta]
  • CG10242-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Probable cytochrome P450 6a23 (CYPVIA23) [nr-271106-contam.fasta]
  • Cyp6a23 CG10242-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(10763366..10764452,10764518..10764939); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189; MD5=62cfe0c32e572870494b56687a63241a; length=502; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(10763366..10764452,10764518..10764939); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189; MD5=62cfe0c32e572870494b56687a63241a; length=502; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • FI03292p OS=Drosophila melanogaster GN=Cyp6a23-RA PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(10763366..10764452,10764518..10764939); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189,FlyMine:FBpp0086582,modMine:FBpp0086582; MD5=62cfe0c32e572870494b56687a63241a; length=502; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(14875861..14876947,14877013..14877434); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189,FlyMine:FBpp0086582,modMine:FBpp0086582; MD5=62cfe0c32e572870494b56687a63241a; length=502; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(14875861..14876947,14877013..14877434); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189,FlyMine:FBpp0086582,modMine:FBpp0086582; MD5=62cfe0c32e572870494b56687a63241a; length=502; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0086582 type=protein; loc=2R:join(14875861..14876947,14877013..14877434); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189,FlyMine:FBpp0086582,modMine:FBpp0086582; MD5=62cfe0c32e572870494b56687a63241a; length=502; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(14875861..14876947,14877013..14877434); ID=FBpp0086582; name=Cyp6a23-PA; parent=FBgn0033978,FBtr0087452; dbxref=FlyBase:FBpp0086582,FlyBase_Annotation_IDs:CG10242-PA,GB_protein:AAF58189.2,REFSEQ:NP_611000,GB_protein:AAF58189,UniProt/Swiss-Prot:Q9V771,FlyMine:FBpp0086582,modMine:FBpp0086582; MD5=62cfe0c32e572870494b56687a63241a; length=502; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 502 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLLTLIAL LVSLLLFMAR RRHGYWQRRG IPHDVPHPIY GNMKDWPKKR HIAMIFRDYY  60
   61 TKYKRSVYPF AGFYFFFTRS AVITDLELVK RVLIKDFNHF ENRGIFYNEI DDPLSATLFS 120
  121 IEGQKWRHLR HKLTPTFTSG KMKNMFPIIV KVGEEMEKIF SAKTTTGEGQ VLEIVDLVAR 180
  181 YTADVIGNCA FGLNCNSLQN PNAEFVTIGK RAIIERRYGG LLDFLIFGFP KLSRRLRLKL 240
  241 NVQDVEDFYT SIVRNTIDYR LRTNEKRHDF MDSLIEMYEK EQAGNTEDGL SFNEILAQAF 300
  301 IFFVAGFETS STTMGFALYE LALDQDIQDQ LRAEINNVLS KHNNEFTYEG IKEMKYLEQV 360
  361 VMETLRKYPV LAHLTRMTQT DFSPEDPKYF IAKGTTVVIP ALGIHYDPEI YPEPEKFKPE 420
  421 RFTDEAIAAR PSCTWLPFGE GPRNCIGLRF GLMQACVGLA YLIRGYKFSV STETQIPMKF 480
  481 VVKSILLSAE NGIHLKVEKL SK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..502] PSI-BLAST 102.0 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • electron carrier activity
    		•  4.64931978461551 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • oxygen binding
    		•  3.29945075872446 bayes_pls_golite062009
  • demethylase activity
    		•  2.80780658333504 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  2.60901411823382 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.33937429425924 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • retinoid binding
    		•  1.91237853759594 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.78853880472253 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • retinoic acid binding
    		•  1.55035199545719 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  1.48500938886158 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  1.00908437413492 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.450436868179747 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.203772707673481 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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