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Protein Overview: FBpp0309004, FBp...

General Information:
Name(s) found: FBpp0311630 [FlyBase]
FBpp0309004 [FlyBase]
Cyp6a22-PA / FBpp0086580 [FlyBase]
Description(s) found:
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  • gi|7303126|gb|AAF58191.1| Cyp6a22 [Drosophila melanogaster] [NCBI NR]
  • gi|24653734|ref|NP_652075.1| Cyp6a22 [Drosophila melanogaster] [NCBI NR]
  • gi|20976852|gb|AAM27501.1| LD04267p [Drosophila melanogaster] [NCBI NR]
  • gi|12643917|sp|Q9V769.1|C6A22_DROME RecName: Full=Cytochrome P450 6a22; AltName: Full=CYPVIA22 [NCBI NR]
  • (Q9V769) Cytochrome P450 6a22 (EC 1.14.-.-) (CYPVIA22) [Swiss-Prot]
  • Cytochrome P450 6a22 OS=Drosophila melanogaster GN=Cyp6a22 PE=2 SV=1 [Swiss-Prot]
  • type=protein; loc=2R:join(10759308..10760373,10760441..10760874); ID=FBpp0311630; name=Cyp6a22-PC; parent=FBgn0013773,FBtr0345526; dbxref=FlyBase:FBpp0311630,FlyBase_Annotation_IDs:CG10240-PC; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=2R:join(10759308..10760373,10760441..10760874); ID=FBpp0309004; name=Cyp6a22-PB; parent=FBgn0013773,FBtr0339983; dbxref=FlyBase:FBpp0309004,FlyBase_Annotation_IDs:CG10240-PB; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r5.56; species=Dmel; [FlyBase]
  • The gene Cyp6a22 is referred to in FlyBase by the symbol Dmel\Cyp6a22 (CG10240, FBgn0013773). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10759178..10760970. It has the cytological map location 51C7-51D1. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10240-PA translation from_gene[CG10240 Cyp6a22 FBgn0013773] seq_release:3 mol_weight=57278 cds_boundaries:(2R:9,935,529..9,937,092[+]) aa_length:499 transcript_info:[CG10240-RA seq_release:3] gene_info:[gene symbol:Cyp6a22 FBgn0013773 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003813) Cyp6a22 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG10240-PA [Drosophila melanogaster]gi|20976852|gb|AAM27501.1| LD04267p [Drosophila melanogaster]gi|24653734|ref|NP_652075.1| CG10240-PA [Drosophila melanogaster]gi|12643917|sp|Q9V769|C6AM_DROME Cytochrome P450 6a22 (CYPVIA22) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(10759308..10760373,10760441..10760874); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191; MD5 [fly-100309-contam.fasta]
  • Cytochrome P450 6a22 (CYPVIA22) [nr-271106-contam.fasta]
  • CG10240-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Cyp6a22 CG10240-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD04267p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(10759308..10760373,10760441..10760874); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(10759308..10760373,10760441..10760874); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Cytochrome P450 6a22 OS=Drosophila melanogaster GN=Cyp6a22 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(10759308..10760373,10760441..10760874); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191,FlyMine:FBpp0086580,modMine:FBpp0086580; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191,FlyMine:FBpp0086580,modMine:FBpp0086580; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0309004; name=Cyp6a22-PB; parent=FBgn0013773,FBtr0339983; dbxref=FlyBase:FBpp0309004,FlyBase_Annotation_IDs:CG10240-PB,GB_protein:AHN56229,REFSEQ:NP_001286431; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0311630; name=Cyp6a22-PC; parent=FBgn0013773,FBtr0345526; dbxref=FlyBase:FBpp0311630,FlyBase_Annotation_IDs:CG10240-PC,GB_protein:AHN56230,REFSEQ:NP_001286432; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191,FlyMine:FBpp0086580,modMine:FBpp0086580; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0309004; name=Cyp6a22-PB; parent=FBgn0013773,FBtr0339983; dbxref=FlyBase:FBpp0309004,FlyBase_Annotation_IDs:CG10240-PB,GB_protein:AHN56229,REFSEQ:NP_001286431; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0311630; name=Cyp6a22-PC; parent=FBgn0013773,FBtr0345526; dbxref=FlyBase:FBpp0311630,FlyBase_Annotation_IDs:CG10240-PC,GB_protein:AHN56230,REFSEQ:NP_001286432; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9V769, Cyp6a22, isoform B OS=Drosophila melanogaster GN=Cyp6a22 PE=3 SV=1 [DROME.fasta.20160308]
  • FBpp0086580 type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191,FlyMine:FBpp0086580,modMine:FBpp0086580; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0309004 type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0309004; name=Cyp6a22-PB; parent=FBgn0013773,FBtr0339983; dbxref=FlyBase:FBpp0309004,FlyBase_Annotation_IDs:CG10240-PB,GB_protein:AHN56229,REFSEQ:NP_001286431; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0311630 type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0311630; name=Cyp6a22-PC; parent=FBgn0013773,FBtr0345526; dbxref=FlyBase:FBpp0311630,FlyBase_Annotation_IDs:CG10240-PC,GB_protein:AHN56230,REFSEQ:NP_001286432; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0086580; name=Cyp6a22-PA; parent=FBgn0013773,FBtr0087450; dbxref=FlyBase:FBpp0086580,FlyBase_Annotation_IDs:CG10240-PA,GB_protein:AAF58191.1,REFSEQ:NP_652075,GB_protein:AAF58191,UniProt/Swiss-Prot:Q9V769,FlyMine:FBpp0086580,modMine:FBpp0086580; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0309004; name=Cyp6a22-PB; parent=FBgn0013773,FBtr0339983; dbxref=FlyBase:FBpp0309004,FlyBase_Annotation_IDs:CG10240-PB,GB_protein:AHN56229,REFSEQ:NP_001286431,UniProt/Swiss-Prot:Q9V769; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=2R:join(14871803..14872868,14872936..14873369); ID=FBpp0311630; name=Cyp6a22-PC; parent=FBgn0013773,FBtr0345526; dbxref=FlyBase:FBpp0311630,FlyBase_Annotation_IDs:CG10240-PC,GB_protein:AHN56230,REFSEQ:NP_001286432,UniProt/Swiss-Prot:Q9V769; MD5=ab0b91ed4fc13658017581863bbfb647; length=499; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 499 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDVVALLLI ALAVGFWFVR TRYSYWTRRG IGSEPARFPV GNMEGFRKNK HFIDIVTPIY  60
   61 EKFKGNGAPF AGFFMMLRPV VLVTDLELAK QILIQDFANF EDRGMYHNER DDPLTGHLFR 120
  121 IDGPKWRPLR QKMSPTFTSA KMKYMFPTVC EVGEELTQVC GELADNAMCG ILEIGDLMAR 180
  181 YTSDVIGRCA FGVECNGLRN PEAEFAIMGR RAFSERRHCK LVDGFIESFP EVARFLRMRQ 240
  241 IHQDITDFYV GIVRETVKQR EEQGIVRSDF MNLLIEMKQR GELTIEEMAA QAFIFFAAGF 300
  301 DTSASTLGFA LYELAKQPAL QAKLREEIDQ ALRLHNGEFT YDSMQELRYM ELVIAETLRK 360
  361 YPILPQLTRI SRHLYAAKGD RHFYIEPGQM LLIPVYGIHH DPALYPEPHK FIPERFLADQ 420
  421 LAQRPTAAWL PFGDGPRNCI GMRFGKMQTT IGLVSLLRNF HFSVCPRTDP KIEFLKSNIL 480
  481 LCPANGIYLK VQQLSQMSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..499] PSI-BLAST 101.0 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • electron carrier activity
    		•  4.64931978461551 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • demethylase activity
    		•  2.80780658333504 bayes_pls_golite062009
  • oxygen binding
    		•  2.77495508953933 bayes_pls_golite062009
  • retinoic acid binding
    		•  2.70323898361882 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.33937429425924 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.450436868179747 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.203772707673481 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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