Protein Overview: Iswi-PA, Iswi-PB...

General Information:
Name(s) found:	Iswi-PC / FBpp0086956 [FlyBase] Iswi-PB / FBpp0086955 [FlyBase] Iswi-PA / FBpp0086954 [FlyBase]
Description(s) found: Found 51 descriptions. SHOW ALL	The gene Imitation SWI is referred to in FlyBase by the symbol Dmel\Iswi (CG8625, FBgn0011604). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8524123..8528133. It has the cytological map location 49B10. There is experimental evidence that it has the molecular function</span>: protein binding; DNA-dependent ATPase activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: chromatin organization; regulation of biological process; organelle organization; cellular macromolecular complex subunit organization; chromosome organization; anatomical structure development; regulation of metabolic process; negative regulation of cellular biosynthetic process; biopolymer biosynthetic process; response to hormone stimulus. 15 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; mechanosensory chaeta; polytene chromosome; dorsocentral bristle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene Imitation SWI is referred to in FlyBase by the symbol Dmel\Iswi (CG8625, FBgn0011604). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8524123..8528133. It has the cytological map location 49B10. There is experimental evidence that it has the molecular function</span>: protein binding; DNA-dependent ATPase activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: chromatin organization; regulation of biological process; organelle organization; cellular macromolecular complex subunit organization; chromosome organization; anatomical structure development; regulation of metabolic process; negative regulation of cellular biosynthetic process; biopolymer biosynthetic process; response to hormone stimulus. 15 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; mechanosensory chaeta; polytene chromosome; dorsocentral bristle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene Imitation SWI is referred to in FlyBase by the symbol Dmel\Iswi (CG8625, FBgn0011604). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8524123..8528133. It has the cytological map location 49B10. There is experimental evidence that it has the molecular function</span>: protein binding; DNA-dependent ATPase activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: chromatin organization; regulation of biological process; organelle organization; cellular macromolecular complex subunit organization; chromosome organization; anatomical structure development; regulation of metabolic process; negative regulation of cellular biosynthetic process; biopolymer biosynthetic process; response to hormone stimulus. 15 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; mechanosensory chaeta; polytene chromosome; dorsocentral bristle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1027 amino acids
Gene Ontology:
Cellular Component:	transcription factor complex [IPI] ACF complex [IDA][NAS][TAS] [NOT]brahma complex [IDA] chromatin remodeling complex [ISS] chromatin accessibility complex [IDA][NAS][TAS] NURF complex [IDA][NAS][TAS]
Biological Process:	transcription [IDA] negative regulation of gene-specific transcription [IMP] ecdysone receptor-mediated signaling pathway [IGI] regulation of transcription, DNA-dependent [IDA] chromatin assembly or disassembly [IDA][TAS] positive regulation of transcription [TAS] regulation of circadian rhythm [IMP] nucleosome assembly [IDA] nucleosome mobilization [IDA][TAS] dendrite morphogenesis [IMP] muscle organ development [IMP] chromatin remodeling [NAS][TAS] ATP-dependent chromatin remodeling [IEA] nucleosome positioning [IDA]
Molecular Function:	nucleotide binding [TAS] ATPase activity [NAS] ATP binding [ISS] DNA binding [IEA] DNA-dependent ATPase activity [IDA][IGI] DNA helicase activity [TAS] protein binding [IPI] nucleosome binding [IEA] general RNA polymerase II transcription factor activity [ISS] helicase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKTDTAAVE ATEENSNETT SDAATSSSGE KEAEFDNKIE ADRSRRFDFL LKQTEIFTHF  60
   61 MTNSAKSPTK PKGRPKKIKD KDKEKDVADH RHRKTEQEED EELLAEDSAT KEIFRFDASP 120
  121 AYIKSGEMRD YQIRGLNWMI SLYENGINGI LADEMGLGKT LQTISLLGYL KHFKNQAGPH 180
  181 IVIVPKSTLQ NWVNEFKKWC PSLRAVCLIG DQDTRNTFIR DVLMPGEWDV CVTSYEMCIR 240
  241 EKSVFKKFNW RYLVIDEAHR IKNEKSKLSE ILREFKTANR LLITGTPLQN NLHELWALLN 300
  301 FLLPDVFNSS EDFDEWFNTN TCLGDDALIT RLHAVLKPFL LRRLKAEVEK RLKPKKEMKI 360
  361 FVGLSKMQRD WYTKVLLKDI DVVNGAGKVE KMRLQNILMQ LRKCTNHPYL FDGAEPGPPY 420
  421 TTDTHLVYNS GKMAILDKLL PKLQEQGSRV LIFSQMTRML DILEDYCHWR NYNYCRLDGQ 480
  481 TPHEDRNRQI QEFNMDNSAK FLFMLSTRAG GLGINLATAD VVIIYDSDWN PQMDLQAMDR 540
  541 AHRIGQKKQV RVFRLITEST VEEKIVERAE VKLRLDKMVI QGGRLVDNRS NQLNKDEMLN 600
  601 IIRFGANQVF SSKETDITDE DIDVILERGE AKTAEQKAAL DSLGESSLRT FTMDTNGEAG 660
  661 TSSVYQFEGE DWREKQKLNA LGNWIEPPKR ERKANYAVDA YFREALRVSE PKAPKAPRPP 720
  721 KQPIVQDFQF FPPRLFELLD QEIYYFRKTV GYKVPKNTEL GSDATKVQRE EQRKIDEAEP 780
  781 LTEEEIQEKE NLLSQGFTAW TKRDFNQFIK ANEKYGRDDI DNIAKDVEGK TPEEVIEYNA 840
  841 VFWERCTELQ DIERIMGQIE RGEGKIQRRL SIKKALDQKM SRYRAPFHQL RLQYGNNKGK 900
  901 NYTEIEDRFL VCMLHKLGFD KENVYEELRA AIRASPQFRF DWFIKSRTAL ELQRRCNTLI 960
  961 TLIERENIEL EEKERAEKKK KAPKGSVSAG SGSASSNTPA PAPQPKASQK RKSEVVATSS1020
 1021 NSKKKKK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

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Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
chromatin binding	3.84065302930105	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
protein binding	2.66728689880621	bayes_pls_golite062009
transcription elongation regulator activity	2.46353586381231	bayes_pls_golite062009
transcription repressor activity	2.45308491935607	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
histone binding	2.00388175060339	bayes_pls_golite062009
transcription activator activity	1.46529895769882	bayes_pls_golite062009
sequence-specific DNA binding	1.10020047862576	bayes_pls_golite062009
methylated histone residue binding	1.03331560428208	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	3.1726526166851	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
structural constituent of ribosome	1.47858140861683	bayes_pls_golite062009
DNA-dependent ATPase activity	1.23094623498843	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
purine ribonucleotide binding	1.21658213854831	bayes_pls_golite062009
ribonucleotide binding	1.21652144153182	bayes_pls_golite062009
purine nucleotide binding	1.21571071905795	bayes_pls_golite062009
nucleotide binding	1.20347573865566	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
transcription elongation regulator activity	1.11383295816593	bayes_pls_golite062009
histone acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription activator activity	0.889929694023098	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
structural molecule activity	0.86514677273731	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.729056749897011	bayes_pls_golite062009
steroid hormone receptor binding	0.647625526012423	bayes_pls_golite062009
structure-specific DNA binding	0.620212706423176	bayes_pls_golite062009
helicase activity	0.6191010101321	bayes_pls_golite062009
microtubule motor activity	0.60036517876321	bayes_pls_golite062009
DNA helicase activity	0.57378485697982	bayes_pls_golite062009
sequence-specific DNA binding	0.543891899378373	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
DNA clamp loader activity	0.49811753387851	bayes_pls_golite062009
double-stranded DNA binding	0.49000746592281	bayes_pls_golite062009
guanyl nucleotide binding	0.388587892299301	bayes_pls_golite062009
guanyl ribonucleotide binding	0.372638007722845	bayes_pls_golite062009
GTP binding	0.364508542344128	bayes_pls_golite062009
hormone receptor binding	0.351501100511918	bayes_pls_golite062009
centromeric DNA binding	0.322818640526369	bayes_pls_golite062009
ATP-dependent helicase activity	0.29664013896754	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.29664013896754	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.24825301806267	bayes_pls_golite062009
nuclear hormone receptor binding	0.246160342138071	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.243902356228423	bayes_pls_golite062009
GTPase activity	0.234351968078991	bayes_pls_golite062009
ATP binding	0.1860481660648	bayes_pls_golite062009
RNA helicase activity	0.18426050934025	bayes_pls_golite062009
adenyl ribonucleotide binding	0.152859582615242	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.147579541298736	bayes_pls_golite062009
RNA-dependent ATPase activity	0.14606996093053	bayes_pls_golite062009
adenyl nucleotide binding	0.138615225841109	bayes_pls_golite062009
pyrophosphatase activity	0.133017653323467	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.13050483816765	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.113504049290503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.111293884322157	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..115]	PSI-BLAST	4.09691	Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
2	View Details	[116..668]	PSI-BLAST	85.154902	Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
3	View Details	[669..1027]	PSI-BLAST	59.522879	nucleosome recognition module of ISWI ATPase

Protein Overview: Iswi-PA, Iswi-PB...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: