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Protein Overview: P2RX7_RAT

General Information:
Name(s) found: P2RX7_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • P2X purinoceptor 7 OS=Rattus norvegicus GN=P2rx7 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 595 amino acids

    Gene Ontology:
    Cellular Component: synaptosome [UNKNOWN][IDA]
    external side of plasma membrane [UNKNOWN][IEA]
    neuronal cell body [UNKNOWN][IEA]
    plasma membrane [UNKNOWN][IDA]
    integral to plasma membrane [UNKNOWN][IEA]
    cell-cell junction [UNKNOWN][IEA]
    integral to nuclear inner membrane [IDA]
    cytoplasm [IDA]
    terminal button [IDA]
    membrane [UNKNOWN]
    membrane raft [IDA]
    bleb [IDA]
    neuromuscular junction [UNKNOWN][IEA]
    Biological Process: cytolysis [UNKNOWN]
    positive regulation of interleukin-1 alpha secretion [UNKNOWN][IEA]
    positive regulation of interleukin-1 beta secretion [UNKNOWN][IDA][IMP]
    pore complex assembly [UNKNOWN][IDA][IMP]
    cell volume homeostasis [UNKNOWN][IEA]
    T cell homeostasis [UNKNOWN][IEA]
    activation of MAPK activity [UNKNOWN][IEA]
    inflammatory response [UNKNOWN][IEA]
    plasma membrane organization [UNKNOWN][IEA]
    cell death [UNKNOWN]
    phospholipid translocation [UNKNOWN][IEA]
    positive regulation of cytokine secretion [UNKNOWN][IEA]
    positive regulation of protein secretion [UNKNOWN]
    release of sequestered calcium ion into cytosol [UNKNOWN][IEA]
    response to electrical stimulus [UNKNOWN][IEA]
    positive regulation of bone mineralization [UNKNOWN][IEA]
    defense response to Gram-positive bacterium [UNKNOWN][IEA]
    collagen metabolic process [UNKNOWN][IEA]
    response to organic substance [UNKNOWN]
    cell morphogenesis [UNKNOWN][IEA]
    regulation of apoptosis [IDA]
    response to organic cyclic substance [UNKNOWN][IEA]
    negative regulation of bone resorption [UNKNOWN][IEA]
    positive regulation of ossification [UNKNOWN]
    phospholipid transfer to membrane [UNKNOWN][IEA]
    oxygen and reactive oxygen species metabolic process [UNKNOWN][IEA]
    cellular response to extracellular stimulus [UNKNOWN][IEA]
    positive regulation of cytoskeleton organization [IDA]
    positive regulation of catalytic activity [UNKNOWN][IEA]
    multicellular organismal protein catabolic process [UNKNOWN][IEA]
    gene expression [UNKNOWN][IEA]
    sensory perception of pain [IEA]
    protein processing [UNKNOWN][IEA]
    positive regulation of T cell mediated cytotoxicity [UNKNOWN][IEA]
    positive regulation of interleukin-6 production [UNKNOWN][IEA]
    membrane depolarization [UNKNOWN][IDA]
    protein oligomerization [UNKNOWN][IEA]
    response to zinc ion [UNKNOWN][IEA]
    organic cation transport [TAS]
    negative regulation of MAPKKK cascade [UNKNOWN][IEA]
    ceramide biosynthetic process [UNKNOWN][IEA]
    protein amino acid phosphorylation [UNKNOWN]
    response to mechanical stimulus [UNKNOWN][IEA]
    positive regulation of prostaglandin secretion [UNKNOWN][IEA]
    cation transport [UNKNOWN]
    phagolysosome assembly [UNKNOWN][IEA]
    NAD transport [UNKNOWN][IEA]
    calcium ion transport [UNKNOWN][IEA]
    positive regulation of mitochondrial depolarization [UNKNOWN][IEA]
    synaptic vesicle exocytosis [UNKNOWN][IEA]
    response to protein stimulus [UNKNOWN][IEA]
    response to fluid shear stress [UNKNOWN][IEA]
    regulation of action potential in neuron [IDA]
    bleb assembly [UNKNOWN][IDA]
    positive regulation of cytolysis [IDA]
    positive regulation of gamma-aminobutyric acid secretion [UNKNOWN][IEA]
    response to ATP [UNKNOWN][IDA]
    cell surface receptor linked signaling pathway [IDA]
    positive regulation of MAPKKK cascade [UNKNOWN][IEA]
    skeletal system morphogenesis [UNKNOWN][IEA]
    mitochondrion organization [UNKNOWN][IEA]
    regulation of sodium ion transport [IDA]
    response to bacterium [UNKNOWN][IEA]
    membrane budding [UNKNOWN][IEA]
    membrane protein ectodomain proteolysis [UNKNOWN][IEA]
    homeostasis of number of cells within a tissue [UNKNOWN][IEA]
    response to drug [UNKNOWN][IEA]
    response to calcium ion [UNKNOWN][IEA]
    positive regulation of protein amino acid phosphorylation [UNKNOWN][IDA]
    T cell proliferation [UNKNOWN][IEA]
    positive regulation of apoptosis [UNKNOWN][IEA]
    response to lipopolysaccharide [UNKNOWN][IEA]
    positive regulation of calcium ion transport into cytosol [UNKNOWN][IEA]
    positive regulation of interleukin-1 beta production [UNKNOWN]
    positive regulation of glutamate secretion [UNKNOWN][IEA]
    Molecular Function: zinc ion binding [IDA]
    channel activity [UNKNOWN][IDA]
    protein serine/threonine kinase activator activity [IC][IMP]
    receptor activity [UNKNOWN][IEA]
    receptor binding [IPI]
    lipopolysaccharide binding [UNKNOWN][IEA]
    magnesium ion binding [IDA]
    extracellular ATP-gated cation channel activity [UNKNOWN][IDA][TAS]
    ion channel activity [IEA]
    ATP binding [UNKNOWN][IDA]
    protein binding [UNKNOWN][IPI]
    copper ion binding [IDA]
    purinergic nucleotide receptor activity [UNKNOWN][IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPACCSWNDV FQYETNKVTR IQSVNYGTIK WILHMTVFSY VSFALMSDKL YQRKEPLISS  60
   61 VHTKVKGVAE VTENVTEGGV TKLVHGIFDT ADYTLPLQGN SFFVMTNYLK SEGQEQKLCP 120
  121 EYPSRGKQCH SDQGCIKGWM DPQSKGIQTG RCIPYDQKRK TCEIFAWCPA EEGKEAPRPA 180
  181 LLRSAENFTV LIKNNIDFPG HNYTTRNILP GMNISCTFHK TWNPQCPIFR LGDIFQEIGE 240
  241 NFTEVAVQGG IMGIEIYWDC NLDSWSHRCQ PKYSFRRLDD KYTNESLFPG YNFRYAKYYK 300
  301 ENGMEKRTLI KAFGVRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLIINTYAS 360
  361 TCCRSRVYPS CKCCEPCAVN EYYYRKKCEP IVEPKPTLKY VSFVDEPHIW MVDQQLLGKS 420
  421 LQDVKGQEVP RPQTDFLELS RLSLSLHHSP PIPGQPEEMQ LLQIEAVPRS RDSPDWCQCG 480
  481 NCLPSQLPEN RRALEELCCR RKPGQCITTS ELFSKIVLSR EALQLLLLYQ EPLLALEGEA 540
  541 INSKLRHCAY RSYATWRFVS QDMADFAILP SCCRWKIRKE FPKTQGQYSG FKYPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.70

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle