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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade. Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of MAPKKK cascade
Acc: GO:0043409
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
Synonyms:
  • inhibition of MAPKKK cascade
  • down-regulation of MAPKKK cascade
  • negative regulation of MAP kinase kinase kinase cascade
  • downregulation of MAPKKK cascade
  • down regulation of MAPKKK cascade
  • negative regulation of mitogen activated protein kinase kinase kinase cascade
  • negative regulation of mitogen-activated protein kinase kinase kinase cascade
Proteins in PDR annotated with:
   This term: 29 [Search]
   Term or descendants: 86 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043409 - negative regulation of MAPKKK cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle