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Protein Overview: BCL10_MOUSE

General Information:
Name(s) found: BCL10_MOUSE [Swiss-Prot]
Description(s) found:
Found 46 descriptions.
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  • B-cell lymphoma/leukemia 10 OS=Mus musculus GN=Bcl10 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 233 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [UNKNOWN][IDA]
    membrane raft [IDA]
    membrane [IEA]
    cytosol [UNKNOWN][IDA]
    protein complex [UNKNOWN]
    intracellular [IEA]
    immunological synapse [IDA]
    Biological Process: protein homooligomerization [IMP]
    [NOT]activation of JUN kinase activity [UNKNOWN]
    regulation of apoptosis [IEA]
    protein heterooligomerization [UNKNOWN]
    response to fungus [IMP]
    mast cell activation [NAS]
    I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IMP]
    positive regulation of NF-kappaB transcription factor activity [UNKNOWN][IMP]
    cellular defense response [IMP]
    positive regulation of T cell activation [IMP]
    neural tube closure [IMP]
    induction of apoptosis [UNKNOWN]
    [NOT]apoptosis [UNKNOWN][IDA][IMP]
    immunoglobulin mediated immune response [IMP]
    regulation of T cell receptor signaling pathway [IMP]
    activation of caspase activity [UNKNOWN]
    Molecular Function: protein homodimerization activity [UNKNOWN]
    protein binding [IPI]
    protein heterodimerization activity [UNKNOWN]
    caspase activator activity [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS  60
   61 SRKRAGKLLD YLQENPRGLD TLVESIRREK TQSFLIQKIT DEVLKLRNIK LEHLKGLKCS 120
  121 SCEPFAAGAT NNLSRCNSDE SNLSEKQRAS TVMYHPEGES STAPFFSMAS SLNLPVLEVG 180
  181 RTENSSFSSA TLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..163] FFAS03 2.68 NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES
    2 View Details [164..233] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transmembrane receptor activity
    		•  3.73453119330332 bayes_pls_golite062009
  • receptor activity
    		•  3.49366126429985 bayes_pls_golite062009
  • binding
    		•  3.31396422903674 bayes_pls_golite062009
  • protein binding
    		•  3.307829551622 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.67610049743177 bayes_pls_golite062009
  • signal transducer activity
    		•  2.67610049743177 bayes_pls_golite062009
  • apoptotic protease activator activity
    		•  2.5547508079121 bayes_pls_golite062009
  • death receptor activity
    		•  1.39783623489153 bayes_pls_golite062009
  • tumor necrosis factor receptor activity
    		•  1.28642537783152 bayes_pls_golite062009
  • tumor necrosis factor binding
    		•  1.2518047572547 bayes_pls_golite062009
  • cytokine binding
    		•  1.19520807262863 bayes_pls_golite062009
  • caspase activator activity
    		•  1.06351832805108 bayes_pls_golite062009
  • kinase activity
    		•  1.02105548570993 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.00874892216117 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.916673725141139 bayes_pls_golite062009
  • caspase regulator activity
    		•  0.891281430232588 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.882621335822208 bayes_pls_golite062009
  • protein kinase activity
    		•  0.730150088863748 bayes_pls_golite062009
  • protease binding
    		•  0.728803593332059 bayes_pls_golite062009
  • enzyme binding
    		•  0.637286996633388 bayes_pls_golite062009
  • interleukin-1 receptor binding
    		•  0.6371200029015 bayes_pls_golite062009
  • kinase binding
    		•  0.545423501018021 bayes_pls_golite062009
  • receptor binding
    		•  0.407742765431869 bayes_pls_golite062009
  • transferase activity
    		•  0.34319852682835 bayes_pls_golite062009
  • death domain binding
    		•  0.321640777907255 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.217428478718826 bayes_pls_golite062009
  • Pyrin domain binding
    		•  0.178843525435003 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.108832545853796 bayes_pls_golite062009
  • peptide binding
    		•  0.0934651586393063 bayes_pls_golite062009
  • catalytic activity
    		•  0.0805685459791233 bayes_pls_golite062009
  • identical protein binding
    		•  0.0457880314943311 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle