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View Structure Prediction Details

Protein: BCL10_MOUSE
Organism: Mus musculus
Length: 233 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BCL10_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109009629 - gi|109009629|ref|XP_001104846.1| PREDICTED: similar to B-cell lymphoma/leukemia 10 (B-cell CLL/lymph...
432.0 [0..1] [233..231]
BCL10_RAT - B-cell lymphoma/leukemia 10 OS=Rattus norvegicus GN=Bcl10 PE=2 SV=1
428.0 [0..1] [233..1]
gi|61367188, gi|... - gi|61367188|gb|AAX42963.1| B-cell CLL/lymphoma 10 [synthetic construct], gi|54696026|gb|AAV38385.1| ...
425.0 [0..1] [233..1]
gi|60812823 - gi|60812823|gb|AAX36233.1| B-cell CLL/lymphoma 10 [synthetic construct]
gi|114557498 - gi|114557498|ref|XP_513526.2| PREDICTED: B-cell CLL/lymphoma 10 [Pan troglodytes]
BCL10 - B-cell CLL/lymphoma 10
424.0 [0..1] [233..1]
gi|73960109 - gi|73960109|ref|XP_547304.2| PREDICTED: similar to B cell lymphoma/leukemia 10 (B-cell CLL/lymphoma ...
420.0 [0..1] [233..1]
gi|119923249, gi... - gi|119923249|ref|XP_001249709.1| PREDICTED: B-cell CLL/lymphoma 10 [Bos taurus], gi|118151148|ref|NP...
405.0 [0..1] [233..1]
gi|82800464, gi|... - gi|94370560|ref|XP_980509.1| PREDICTED: similar to B cell lymphoma/leukemia 10 (B-cell CLL/lymphoma ...
393.0 [0..1] [233..1]

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Predicted Domain #1
Region A:
Residues: [1-163]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS  60
   61 SRKRAGKLLD YLQENPRGLD TLVESIRREK TQSFLIQKIT DEVLKLRNIK LEHLKGLKCS 120
  121 SCEPFAAGAT NNLSRCNSDE SNLSEKQRAS TVMYHPEGES STA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.68
Match: 3crdA
Description: NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 3.73453119330332 bayes_pls_golite062009
receptor activity 3.49366126429985 bayes_pls_golite062009
binding 3.31396422903674 bayes_pls_golite062009
protein binding 3.307829551622 bayes_pls_golite062009
molecular transducer activity 2.67610049743177 bayes_pls_golite062009
signal transducer activity 2.67610049743177 bayes_pls_golite062009
apoptotic protease activator activity 2.5547508079121 bayes_pls_golite062009
death receptor activity 1.39783623489153 bayes_pls_golite062009
tumor necrosis factor receptor activity 1.28642537783152 bayes_pls_golite062009
tumor necrosis factor binding 1.2518047572547 bayes_pls_golite062009
cytokine binding 1.19520807262863 bayes_pls_golite062009
caspase activator activity 1.06351832805108 bayes_pls_golite062009
kinase activity 1.02105548570993 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.00874892216117 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.916673725141139 bayes_pls_golite062009
caspase regulator activity 0.891281430232588 bayes_pls_golite062009
protein domain specific binding 0.882621335822208 bayes_pls_golite062009
protein kinase activity 0.730150088863748 bayes_pls_golite062009
protease binding 0.728803593332059 bayes_pls_golite062009
enzyme binding 0.637286996633388 bayes_pls_golite062009
interleukin-1 receptor binding 0.6371200029015 bayes_pls_golite062009
kinase binding 0.545423501018021 bayes_pls_golite062009
receptor binding 0.407742765431869 bayes_pls_golite062009
transferase activity 0.34319852682835 bayes_pls_golite062009
death domain binding 0.321640777907255 bayes_pls_golite062009
protein serine/threonine kinase activity 0.217428478718826 bayes_pls_golite062009
Pyrin domain binding 0.178843525435003 bayes_pls_golite062009
cysteine-type peptidase activity 0.108832545853796 bayes_pls_golite062009
peptide binding 0.0934651586393063 bayes_pls_golite062009
catalytic activity 0.0805685459791233 bayes_pls_golite062009
identical protein binding 0.0457880314943311 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [164-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFFSMASSLN LPVLEVGRTE NSSFSSATLP RPGDPGAPPL PPDLRLEEGG SCGNSSEMFL  60
   61 PLRSRALSRQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle