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Protein Overview: Dscam-PR

General Information:
Name(s) found: Dscam-PR / FBpp0110387 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2013 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVAQY YDTDVNKAYV IRGNAAVLKC EIPSFVADFV SVVSWHTDQN 180
  181 EDFLPGSEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSIGPRLT SGDESRILRV YLAASATLLC PAQAYPVPFF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMELPQ VDQFHFNANG VNGGQAVRVM CMVSSGDLPI DIYWLKDGQP 660
  661 LLRSIYHKID EYTLILSLRQ TTIGDSGNYT CVASNAAGVA SRWSILKVKV PPRWILEPTD 720
  721 KAFAQGSDAK VECKADGFPK PQVTWKKAVG DTPGEYKDLK KSDNIRVEEG TLHVDNIQKT 780
  781 NEGYYLCEAI NGIGSGLSAV IMISVQAPPE FTEKLRNQTA RRGEPAVLQC EAKGEKPIGI 840
  841 LWNMNNMRLD PKNDNRYTIR EEILSTGVMS SLSIKRTERS DSALFTCVAT NAFGSDDASI 900
  901 NMIVQEVPEM PYALKVLDKS GRSVQLSWAQ PYDGNSPLDR YIIEFKRSRA SWSEIDRVIV 960
  961 PGHTTEAQVQ KLSPATTYNI RIVAENAIGT SQSSEAVTII TAEEAPSGKP QNIKVEPVNQ1020
 1021 TTMRVTWKPP PRTEWNGEIL GYYVGYKLSN TNSSYVFETI NFITEEGKEH NLELQNLRVY1080
 1081 TQYSVVIQAF NKIGAGPLSE EEKQFTAEGT PSQPPSDTAC TTLTSQTIRV GWVSPPLESA1140
 1141 NGVIKTYKVV YAPSDEWYDE TKRHYKKTAS SDTVLHGLKK YTNYTMQVLA TTAGGDGVRS1200
 1201 VPIHCQTEPD VPEAPTDVKA LVMGNAAILV SWRPPAQPNG IITQYTVYSK AEGAETETKT1260
 1261 QKVPHYQMSF EATELEKNKP YEFWVTASTT IGEGQQSKSI VAMPSDQVPA KIASFDDTFT1320
 1321 ATFKEDAKMP CLAVGAPQPE ITWKIKGVEF SANDRMRVLP DGSLLIKSVN RQDAGDYSCH1380
 1381 AENSIAKDSI THKLIVLAPP QSPHVTLSAT TTDALTVKLK PHEGDTAPLH GYTLHYKPEF1440
 1441 GEWETSEVSV DSQKHNIEGL LCGSRYQVYA TGFNNIGAGE ASDILNTRTK GQKPKLPEKP1500
 1501 RFIEVSSNSV SLHFKAWKDG GCPMSHFVVE SKKRDQIEWN QISNNVKPDN NYVVLDLEPA1560
 1561 TWYNLRITAH NSAGFTVAEY DFATLTVTGG TIAPSRDLPE LSAEDTIRII LSNLNLVVPV1620
 1621 VAALLVIIIA IIVICILRSK GNHHKDDVVY NQTMGPGATL DKRRPDLRDE LGYIAPPNRK1680
 1681 LPPVPGSNYN TCDRIKRGRG GLRSNHSTWD PRRNPNLYEE LKAPPVPMHG NHYGHAHGNA1740
 1741 ECHYRHPGME DEICPYATFH LLGFREEMDP TKAMNFQTFP HQNGHAGPVP GHAGTMLPPG1800
 1801 HPGHVHSRSG SQSMPRANRY QRKNSQGGQS SIYTPAPEYD DPANCAEEDQ YRRYTRVNSQ1860
 1861 GGSLYSGPGP EYDDPANCAP EEDQYGSQYG GPYGQPYDHY GSRGSMGRRS IGSARNPGNG1920
 1921 SPEPPPPPPR NHDMSNSSFN DSKESNEISE AECDRDHGPR GNYGAVKRSP QPKDQRTTEE1980
 1981 MRKLIERNET GPKQLQLQQA NGAGFTAYDT MAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] PSI-BLAST 80.69897 No description for 2v5sA was found.
    2 View Details [145..252] PSI-BLAST 10.09691 Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
    3 View Details [253..906] PSI-BLAST 58.69897 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    4 View Details [907..1004] PSI-BLAST 37.30103 No description for 2nziA was found.
    5 View Details [1005..1109] PSI-BLAST 10.522879 No description for 2edxA was found.
    6 View Details [1110..1481] PSI-BLAST 13.154902 No description for 1zlgA was found.
    7 View Details [1482..1595] PSI-BLAST 12.154902 Solution structure of the fibronectin type-III domain of human fibronectin type-III domain containing protein 3a
    8 View Details [1596..1784] deduced N/A No confident structure predictions are available.
    9 View Details [1785..2013] MSA 1.126992 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • antigen binding
    		•  5.59543448804521 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • olfactory receptor activity
    		•  4.21057154107121 bayes_pls_golite062009
  • receptor activity
    		•  4.00123250685257 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.81769911097805 bayes_pls_golite062009
  • peptide antigen binding
    		•  3.64034637674979 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • signal transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.83860944503193 bayes_pls_golite062009
  • IgG binding
    		•  2.62006935586983 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • IgE binding
    		•  1.73481096568834 bayes_pls_golite062009
  • IgE receptor activity
    		•  1.73481096568834 bayes_pls_golite062009
  • receptor binding
    		•  1.70260377709721 bayes_pls_golite062009
  • growth factor binding
    		•  1.60826091835429 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.27793818082552 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.17845072849922 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.02428106476324 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.02286631988334 bayes_pls_golite062009
  • kinase activity
    		•  0.929878054374821 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.878595022643164 bayes_pls_golite062009
  • sugar binding
    		•  0.851973726002024 bayes_pls_golite062009
  • immunoglobulin binding
    		•  0.84834833214265 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • peptide binding
    		•  0.729048089532569 bayes_pls_golite062009
  • coreceptor activity
    		•  0.661209696849389 bayes_pls_golite062009
  • collagen binding
    		•  0.635057461053063 bayes_pls_golite062009
  • cytokine binding
    		•  0.631436442105379 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009
  • structural molecule activity
    		•  0.567620977360967 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • immunoglobulin receptor activity
    		•  0.53605856667766 bayes_pls_golite062009
  • IgG receptor activity
    		•  0.50231877534761 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.49788128784685 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.447829399094714 bayes_pls_golite062009
  • cytokine receptor activity
    		•  0.34165331857492 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.28309679787333 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • telethonin binding
    		•  5.81747667416248 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.71979489668015 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.57951951779666 bayes_pls_golite062009
  • actinin binding
    		•  4.57900103206288 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • growth factor binding
    		•  3.39021787583547 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • interleukin-2 binding
    		•  2.68205932397612 bayes_pls_golite062009
  • interleukin-7 binding
    		•  2.52651471003365 bayes_pls_golite062009
  • receptor binding
    		•  2.38673889309915 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  2.15011619378442 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • interleukin-12 binding
    		•  1.99482977929342 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  1.99168831878759 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  1.99168831878759 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.9781930293417 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.9781930293417 bayes_pls_golite062009
  • prolactin receptor activity
    		•  1.9556649101819 bayes_pls_golite062009
  • cytokine activity
    		•  1.93281236178924 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.85720106085239 bayes_pls_golite062009
  • interleukin-11 binding
    		•  1.57103867592521 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  1.57103867592521 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.56410665522466 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.49217960276915 bayes_pls_golite062009
  • mercury ion binding
    		•  1.46191698606762 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32813363771214 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • actin binding
    		•  1.21472460452555 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • growth factor activity
    		•  1.16355032792247 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • heparin binding
    		•  1.15000556789505 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  1.1057194345531 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  1.10508957821356 bayes_pls_golite062009
  • sialic acid binding
    		•  0.992369242781511 bayes_pls_golite062009
  • structural molecule activity
    		•  0.94240190391222 bayes_pls_golite062009
  • interleukin-12 alpha subunit binding
    		•  0.924116090838821 bayes_pls_golite062009
  • peptide binding
    		•  0.92031154055894 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  0.840187286074179 bayes_pls_golite062009
  • pattern binding
    		•  0.82756944920828 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.78428502513367 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • collagen binding
    		•  0.593745877718282 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  0.578087868054051 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.54737137289904 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.40600177052491 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  0.338520586013721 bayes_pls_golite062009
  • peptidase activator activity
    		•  0.249363133780499 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • actin filament binding
    		•  0.135484838710405 bayes_pls_golite062009
  • protease binding
    		•  0.12595904253108 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • sugar binding
    		•  0.113922042820831 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
  • interleukin-12 receptor binding
    		•  0.0393437987205916 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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