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Protein Overview: ERBB3

General Information:
Name(s) found: ERBB3 [HGNC (HUGO)]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1342 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM  60
   61 GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120
  121 LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 180
  181 RSCPPCHEVC KGRCWGPGSE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 240
  241 TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 300
  301 CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 360
  361 LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420
  421 RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TKVLRGPTEE 480
  481 RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 540
  541 REFAHEAECF SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI 600
  601 YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA GLVVIFMMLG 660
  661 GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL ARIFKETELR KLKVLGSGVF 720
  721 GTVHKGVWIP EGESIKIPVC IKVIEDKSGR QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG 780
  781 SSLQLVTQYL PLGSLLDHVR QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV 840
  841 LLKSPSQVQV ADFGVADLLP PDDKQLLYSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT 900
  901 VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI DENIRPTFKE 960
  961 LANEFTRMAR DPPRYLVIKR ESGPGIAPGP EPHGLTNKKL EEVELEPELD LDLDLEAEED1020
 1021 NLATTTLGSA LSLPVGTLNR PRGSQSLLSP SSGYMPMNQG NLGESCQESA VSGSSERCPR1080
 1081 PVSLHPMPRG CLASESSEGH VTGSEAELQE KVSMCRSRSR SRSPRPRGDS AYHSQRHSLL1140
 1141 TPVTPLSPPG LEEEDVNGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE EDEDEEYEYM1200
 1201 NRRRRHSPPH PPRPSSLEEL GYEYMDVGSD LSASLGSTQS CPLHPVPIMP TAGTTPDEDY1260
 1261 EYMNRQRDGG GPGGDYAAMG ACPASEQGYE EMRAFQGPGH QAPHVHYARL KTLRSLEATD1320
 1321 SAFDNPDYWH SRLFPKANAQ RT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..666] PSI-BLAST 1000.0 Receptor protein-tyrosine kinase Erbb-3 extracellular domain; Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains
    2 View Details [667..991] PSI-BLAST 65.30103 EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
    3 View Details [992..1064] deduced N/A No confident structure predictions are available.
    4 View Details [1065..1157] deduced N/A No confident structure predictions are available.
    5 View Details [1158..1342] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • insulin-like growth factor binding
    		•  6.22969465792364 bayes_pls_golite062009
  • nitric-oxide synthase regulator activity
    		•  5.70266126834184 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  5.38913524516117 bayes_pls_golite062009
  • growth factor binding
    		•  5.25925494280191 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  4.12089913732676 bayes_pls_golite062009
  • epidermal growth factor receptor activity
    		•  3.78895179350059 bayes_pls_golite062009
  • binding
    		•  3.10942625145915 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.09281229196379 bayes_pls_golite062009
  • protein binding
    		•  3.04595153576805 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  2.24697345620464 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.17861327763673 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.11274485218746 bayes_pls_golite062009
  • actin binding
    		•  2.0879486757089 bayes_pls_golite062009
  • receptor activity
    		•  2.04770371945982 bayes_pls_golite062009
  • structural molecule activity
    		•  1.83189461928225 bayes_pls_golite062009
  • signal transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.68559458458962 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64316913174221 bayes_pls_golite062009
  • protein tyrosine phosphatase activator activity
    		•  1.57541239141181 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.50579173120225 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.49158544951255 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48507116784838 bayes_pls_golite062009
  • receptor binding
    		•  1.38917750110812 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.3823186140816 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.36671598599873 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.35826958219514 bayes_pls_golite062009
  • kinase activity
    		•  1.33897988039058 bayes_pls_golite062009
  • phosphatase activator activity
    		•  1.23699452328993 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.07723307116004 bayes_pls_golite062009
  • actin filament binding
    		•  0.987222190475555 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.907118880836251 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.625443680166071 bayes_pls_golite062009
  • heparin binding
    		•  0.590238200498242 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.5845342946602 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.57648672048391 bayes_pls_golite062009
  • phosphatase binding
    		•  0.479382571752751 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.430075899423884 bayes_pls_golite062009
  • protein-hormone receptor activity
    		•  0.42902267001067 bayes_pls_golite062009
  • pattern binding
    		•  0.339536765321749 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.27885603541101 bayes_pls_golite062009
  • catalytic activity
    		•  0.271811389148807 bayes_pls_golite062009
  • hormone binding
    		•  0.10824213144683 bayes_pls_golite062009
  • collagen binding
    		•  0.085405748322021 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • nitric-oxide synthase regulator activity
    		•  5.44200869948164 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • epidermal growth factor receptor activity
    		•  3.94068388872775 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  3.26784640416242 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.03401803018883 bayes_pls_golite062009
  • PTB domain binding
    		•  3.02789234463297 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transferase activity
    		•  2.34875558765742 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  2.18795259566024 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.1677218320705 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.1677218320705 bayes_pls_golite062009
  • insulin receptor activity
    		•  2.13530536490053 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • brain-derived neurotrophic factor binding
    		•  1.68652792375997 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.59883083492481 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • amine binding
    		•  1.3051205627964 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • insulin binding
    		•  1.23861703046323 bayes_pls_golite062009
  • activin binding
    		•  1.22461306010416 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • structural molecule activity
    		•  1.10436308210353 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.06651320735249 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.03817708087796 bayes_pls_golite062009
  • receptor binding
    		•  0.990272341309676 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.964782792058349 bayes_pls_golite062009
  • DNA binding
    		•  0.923923660104752 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.880236579821909 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  0.830144030420023 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  0.82854091092242 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • activin receptor activity
    		•  0.811117252475389 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • transcription factor activity
    		•  0.746157953046096 bayes_pls_golite062009
  • growth factor activity
    		•  0.707777793848936 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • MAP/ERK kinase kinase activity
    		•  0.678816830701899 bayes_pls_golite062009
  • transcription activator activity
    		•  0.645254722299306 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • Janus kinase activity
    		•  0.580310109637219 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.516151105278102 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.406297251827056 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • tubulin binding
    		•  0.385009627613955 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.117759584117941 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.0613131034808199 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.0386657159233388 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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