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Protein Overview: PRKCQ

General Information:
Name(s) found: PRKCQ [HGNC (HUGO)]
Description(s) found:
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  • gi|75517625|gb|AAI01466.1| Protein kinase C, theta [Homo sapiens] [NCBI NR]
  • gi|55957943|emb|CAC12904.2| protein kinase C, theta [Homo sapiens] [NCBI NR]
  • gi|55957459|emb|CAC10200.2| protein kinase C, theta [Homo sapiens] [NCBI NR]
  • gi|558100|gb|AAA60101.1| protein kinase C-theta [NCBI NR]
  • gi|5453976|ref|NP_006248.1| protein kinase C, theta [Homo sapiens] [NCBI NR]
  • pir||A45416 protein kinase C (EC 2.7.1.-) theta - human [NCBI NR]
  • gi|20141582|sp|Q04759.3|KPCT_HUMAN RecName: Full=Protein kinase C theta type; AltName: Full=nPKC-theta [NCBI NR]
  • gi|119606800|gb|EAW86394.1| protein kinase C, theta, isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|109731662|gb|AAI13360.1| Protein kinase C, theta [Homo sapiens] [NCBI NR]
  • protein kinase C, theta [HGNC (HUGO)]
  • Protein kinase C theta type OS=Homo sapiens GN=PRKCQ PE=1 SV=3 [Swiss-Prot]
  • Protein kinase C, theta type [hmr_yeast5_DM3-1_pombe.fasta]
  • protein kinase C, theta [Homo sapiens]gi|423039|pir||A45416 protein kinase C (EC 2.7.1.-) theta - humangi|558100|gb|AAA60101.1| protein kinase C-thetagi|20141582|sp|Q04759|KPCT_HUMAN Protein kinase C, theta type (nPKC-theta) [nrdb_11152004_Chlamydomonas]
  • Protein kinase C, theta type (nPKC-theta) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Protein kinase C theta type [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006257) protein kinase C, theta [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • protein kinase C, theta [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Protein kinase C theta type (nPKC-theta) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • protein kinase C, theta, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Protein kinase C, theta [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • protein kinase C-theta [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Protein kinase C theta type [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 PROTEIN KINASE C, THETA TYPE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PRKCQ Isoform 1 of Protein kinase C theta type [human-ipi-250309-contam.fasta]
  • IPI:IPI00029196.6|SWISS-PROT:Q04759-1|TREMBL:B4DF52|ENSEMBL:ENSP00000263125|REFSEQ:NP_006248|H-INV:HIT000191806|VEGA:OTTHUMP00000019053 Tax_Id=9606 Gene_Symbol=PRKCQ Isoform 1 of Protein kinase C theta type [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PRKCQ Isoform 1 of Protein kinase C theta type ENSG00000065675 IPI00029196 IPI00552075 IPI00470691 [drosphohumanreversed.fasta]
  • protein kinase C theta type [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q04759;Q14DH6;Q3MJF1;Q64FY5;Q9H508;Q9H549; RecName: Full=Protein kinase C theta type; AltName: Full=nPKC-theta; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Protein kinase C theta type OS=Homo sapiens GN=PRKCQ [011711_HMR.fasta]
  • GeneSymbol=PRKCQ Synonyms=MGC126514|MGC141919|PRKCT|nPKC-theta protein kinase C theta type [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00029196.6|SWISS-PROT:Q04759-1|ENSEMBL:ENSP00000263125|REFSEQ:NP_006248|H-INV:HIT000191806|VEGA:OTTHUMP00000019053 Tax_Id=9606 Gene_Symbol=PRKCQ Isoform 1 of Protein kinase C theta type [ipi.HUMAN.20110912.fasta]
  • Protein kinase C theta type GN=PRKCQ [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 706 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF  60
   61 DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GKTEIWLELK PQGRMLMNAR 120
  121 YFLEMSDTKD MNEFETEGFF ALHQRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180
  181 WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240
  241 SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300
  301 ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTPGKRE PQGISWESPL DEVDKMCHLP 360
  361 EPELNKERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD 420
  421 DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 480
  481 ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC 540
  541 GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600
  601 WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPFD 660
  661 CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG MERLIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..51] PSI-BLAST 29.69897 The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain
    2 View Details [52..254] PSI-BLAST 9.69897 Crystal Structure of the Human Beta2-Chimaerin
    3 View Details [255..301] FFAS03 2.18 NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
    4 View Details [302..370] PSI-BLAST 49.154902 Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
    5 View Details [371..706] PSI-BLAST 78.221849 Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.71782887289779 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.86705824967236 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10625597744594 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • kinase activity
    		•  2.03632850156074 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91441035614579 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.8531437045627 bayes_pls_golite062009
  • protein kinase activity
    		•  1.62921423829738 bayes_pls_golite062009
  • transferase activity
    		•  1.4550521488922 bayes_pls_golite062009
  • transcription factor activity
    		•  1.39657429296564 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.39167263636091 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.37139209958305 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.10685156896266 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.956859696337723 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.911061212692491 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.907368864863833 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.661240850692236 bayes_pls_golite062009
  • kinase binding
    		•  0.494958567742569 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
    3
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.46734661087649 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.82097223032126 bayes_pls_golite062009
  • binding
    		•  2.71288992341677 bayes_pls_golite062009
  • protein binding
    		•  2.2604757016607 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.07238897772131 bayes_pls_golite062009
  • DNA binding
    		•  2.05972958088217 bayes_pls_golite062009
  • kinase activity
    		•  2.00903309297046 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91592331431516 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.83466699022067 bayes_pls_golite062009
  • protein kinase activity
    		•  1.61903873760762 bayes_pls_golite062009
  • transferase activity
    		•  1.45394179515146 bayes_pls_golite062009
  • transcription factor activity
    		•  1.38590948364516 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25050856744516 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25050856744516 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.12412426198961 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.10707685935826 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.969266093401353 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.93378879973188 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.717794523788476 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.6091533221871 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.442062495186646 bayes_pls_golite062009
  • kinase binding
    		•  0.409606963040614 bayes_pls_golite062009
  • catalytic activity
    		•  0.216721136299042 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.86530070884042 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.32254739984688 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • transcription activator activity
    		•  0.746097961522136 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.585036697436369 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.568332175782799 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • insulin binding
    		•  0.147382876071569 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • PTB domain binding
    		•  0.0116623342611808 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle