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View Structure Prediction Details

Protein: PRKCQ
Organism: Homo sapiens
Length: 706 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRKCQ.

Description E-value Query
Range		 Subject
Range
gi|114629235, gi... - gi|114629237|ref|XP_001148074.1| PREDICTED: protein kinase C, theta isoform 2 [Pan troglodytes], gi|...
 0.0 [1..706] [1..706]
gi|558099 - gi|558099|gb|AAA75571.1| protein kinase C-theta
 0.0 [1..706] [1..706]
gi|73949094 - gi|73949094|ref|XP_849292.1| PREDICTED: similar to Protein kinase C, theta type (nPKC-theta) isoform...
 0.0 [1..706] [1..706]
KPCT_MOUSE - Protein kinase C theta type OS=Mus musculus GN=Prkcq PE=1 SV=1
 0.0 [1..705] [1..705]
gi|62663808, gi|... - gi|62663808|ref|XP_341554.2| PREDICTED: similar to Protein kinase C theta type (nPKC-theta) isoform ...
 0.0 [1..705] [1..705]
gi|76678711 - gi|76678711|ref|XP_877752.1| PREDICTED: similar to protein kinase C, delta isoform 6 [Bos taurus]
 0.0 [1..704] [1..708]

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Predicted Domain #1
Region A:
Residues: [1-51] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.69897
Match: 1yrkA
Description: The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [52-254] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYPPWDSTFD AHINKGRVMQ IIVKGKNVDL ISETTVELYS LAERCRKNNG KTEIWLELKP  60
   61 QGRMLMNARY FLEMSDTKDM NEFETEGFFA LHQRRGAIKQ AKVHHVKCHE FTATFFPQPT 120
  121 FCSVCHEFVW GLNKQGYQCR QCNAAIHKKC IDKVIAKCTG SAINSRETMF HKERFKIDMP 180
  181 HRFKVYNYKS PTFCEHCGTL LWG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.71782887289779 bayes_pls_golite062009
transcription regulator activity 2.86705824967236 bayes_pls_golite062009
binding 2.79128751898373 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.10625597744594 bayes_pls_golite062009
DNA binding 2.06132216820898 bayes_pls_golite062009
kinase activity 2.03632850156074 bayes_pls_golite062009
nucleic acid binding 1.91441035614579 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.8531437045627 bayes_pls_golite062009
protein kinase activity 1.62921423829738 bayes_pls_golite062009
transferase activity 1.4550521488922 bayes_pls_golite062009
transcription factor activity 1.39657429296564 bayes_pls_golite062009
GTPase regulator activity 1.39167263636091 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.37139209958305 bayes_pls_golite062009
signal transducer activity 1.25507073225414 bayes_pls_golite062009
molecular transducer activity 1.25507073225414 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.10685156896266 bayes_pls_golite062009
protein serine/threonine kinase activity 0.956859696337723 bayes_pls_golite062009
enzyme regulator activity 0.911061212692491 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.907368864863833 bayes_pls_golite062009
small GTPase regulator activity 0.661240850692236 bayes_pls_golite062009
kinase binding 0.494958567742569 bayes_pls_golite062009
catalytic activity 0.194464246602439 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [255-301] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LARQGLKCDA CGMNVHHRCQ TKVANLCGIN QKLMAEALAM IESTQQA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.18
Match: 1tbnA
Description: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.46734661087649 bayes_pls_golite062009
transcription regulator activity 2.82097223032126 bayes_pls_golite062009
binding 2.71288992341677 bayes_pls_golite062009
protein binding 2.2604757016607 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.07238897772131 bayes_pls_golite062009
DNA binding 2.05972958088217 bayes_pls_golite062009
kinase activity 2.00903309297046 bayes_pls_golite062009
nucleic acid binding 1.91592331431516 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.83466699022067 bayes_pls_golite062009
protein kinase activity 1.61903873760762 bayes_pls_golite062009
transferase activity 1.45394179515146 bayes_pls_golite062009
transcription factor activity 1.38590948364516 bayes_pls_golite062009
signal transducer activity 1.25050856744516 bayes_pls_golite062009
molecular transducer activity 1.25050856744516 bayes_pls_golite062009
GTPase regulator activity 1.12412426198961 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.10707685935826 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.969266093401353 bayes_pls_golite062009
protein serine/threonine kinase activity 0.93378879973188 bayes_pls_golite062009
enzyme regulator activity 0.717794523788476 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.6091533221871 bayes_pls_golite062009
small GTPase regulator activity 0.442062495186646 bayes_pls_golite062009
kinase binding 0.409606963040614 bayes_pls_golite062009
catalytic activity 0.216721136299042 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [302-370] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RCLRDTEQIF REGPVEIGLP CSIKNEARPP CLPTPGKREP QGISWESPLD EVDKMCHLPE  60
   61 PELNKERPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.154902
Match: 1opkA
Description: Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [371-706] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD DVECTMVEKR  60
   61 VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR ATFYAAEIIL 120
  121 GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC GTPDYIAPEI 180
  181 LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR WLEKEAKDLL 240
  241 VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPFD CSNFDKEFLN 300
  301 EKPRLSFADR ALINSMDQNM FRNFSFMNPG MERLIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.221849
Match: 1xjdA
Description: Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
ErbB-2 class receptor binding 1.86530070884042 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
transcription activator activity 0.746097961522136 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
insulin receptor activity 0.585036697436369 bayes_pls_golite062009
transcription repressor activity 0.568332175782799 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
insulin binding 0.147382876071569 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
PTB domain binding 0.0116623342611808 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle