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Protein Overview: PNKP

General Information:
Name(s) found: PNKP [HGNC (HUGO)]
Description(s) found:
Found 27 descriptions.
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  • polynucleotide kinase 3'-phosphatase [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 521 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR  60
   61 TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP 120
  121 GTPLVSQDEK RDAELPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR 180
  181 SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV 240
  241 EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANDGTPIS IGDSIFVGDA AGRPANWAPG 300
  301 RKKKDFSCAD RLFALNLGLP FATPEEFFLK WPAAGFELPA FDPRTVSRSG PLCLPESRAL 360
  361 LSASPEVVVA VGFPGAGKST FLKKHLVSAG YVHVNRDTLG SWQRCVTTCE TALKQGKRVA 420
  421 IDNTNPDAAS RARYVQCARA AGVPCRCFLF TATLEQARHN NRFREMTDSS HIPVSDMVMY 480
  481 GYRKQFEAPT LAEGFSAILE IPFRLWVEPR LGRLYCQFSE G

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] PSI-BLAST 29.09691 Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme
    2 View Details [127..521] PSI-BLAST 72.30103 Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.45770879261731 bayes_pls_golite062009
  • protein binding
    		•  2.29525699423584 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19476134368662 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.15186292999347 bayes_pls_golite062009
  • DNA binding
    		•  2.14806411237267 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.99648305813116 bayes_pls_golite062009
  • phosphatase activity
    		•  1.96122534427704 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.95921851331594 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.92787866235446 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  1.90737000037164 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.84746485315093 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.7993031225207 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  1.77430052304093 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.24665557440875 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.23355920609762 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  1.14832992494176 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.14239578881997 bayes_pls_golite062009
  • promoter binding
    		•  1.1349314228381 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.0403919292177 bayes_pls_golite062009
  • transcription factor activity
    		•  1.00126317233035 bayes_pls_golite062009
  • protein kinase activity
    		•  0.956391533542429 bayes_pls_golite062009
  • transcription activator activity
    		•  0.93417628414426 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.648647048549737 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.641170666751583 bayes_pls_golite062009
  • ubiquitin binding
    		•  0.63951996057523 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.59326481279109 bayes_pls_golite062009
  • kinase activity
    		•  0.533969592942037 bayes_pls_golite062009
  • small conjugating protein binding
    		•  0.53318309637792 bayes_pls_golite062009
  • SMAD binding
    		•  0.529987528306404 bayes_pls_golite062009
  • hydrolase activity
    		•  0.34475558174039 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.313294193249444 bayes_pls_golite062009
  • transcription factor binding
    		•  0.28405210686825 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.279328480488455 bayes_pls_golite062009
  • chromatin binding
    		•  0.0581576861375597 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0216801467872398 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphatase activity
    		•  5.1741419126177 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  4.98288537099796 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  4.35132100394658 bayes_pls_golite062009
  • polynucleotide 3'-phosphatase activity
    		•  3.35898650848577 bayes_pls_golite062009
  • nucleotide phosphatase activity
    		•  2.90489006846175 bayes_pls_golite062009
  • hydrolase activity
    		•  2.8454129466116 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  2.48898309484199 bayes_pls_golite062009
  • ATP-dependent polynucleotide kinase activity
    		•  2.29319278342491 bayes_pls_golite062009
  • polydeoxyribonucleotide kinase activity
    		•  2.29319278342491 bayes_pls_golite062009
  • polynucleotide kinase activity
    		•  2.29319278342491 bayes_pls_golite062009
  • ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
    		•  2.29319278342491 bayes_pls_golite062009
  • catalytic activity
    		•  1.55296860681783 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.03193813466144 bayes_pls_golite062009
  • binding
    		•  0.89911057995199 bayes_pls_golite062009
  • DNA binding
    		•  0.717646778444981 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  0.438943767876088 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.399200517663665 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.365064688215173 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.35576808478553 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.353215187799141 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.289666831374877 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.269687349439947 bayes_pls_golite062009
  • kinase activity
    		•  0.213470278166197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle