| Protein: | PNKP |
| Organism: | Homo sapiens |
| Length: | 521 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PNKP.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..521] | [1..521] |
|
|
0.0 | [1..521] | [1..521] |
|
|
0.0 | [1..521] | [1..522] |
|
|
0.0 | [1..521] | [1..522] |
|
|
0.0 | [1..521] | [1..521] |
|
Region A: Residues: [1-126] |
1 11 21 31 41 51
| | | | | |
1 MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR 60
61 TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP 120
121 GTPLVS
|
| Detection Method: |  |
| Confidence: | 29.09691 |
| Match: | 1yj5C |
| Description: | Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 3.45770879261731 | bayes_pls_golite062009 |
| protein binding | 2.29525699423584 | bayes_pls_golite062009 |
| nucleic acid binding | 2.19476134368662 | bayes_pls_golite062009 |
| transcription regulator activity | 2.15186292999347 | bayes_pls_golite062009 |
| DNA binding | 2.14806411237267 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 1.99648305813116 | bayes_pls_golite062009 |
| phosphatase activity | 1.96122534427704 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.95921851331594 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 1.92787866235446 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, cytoplasmic mediator activity | 1.90737000037164 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.84746485315093 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.7993031225207 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase signaling protein activity | 1.77430052304093 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 1.24665557440875 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 1.23355920609762 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | 1.14832992494176 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.14239578881997 | bayes_pls_golite062009 |
| promoter binding | 1.1349314228381 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.0403919292177 | bayes_pls_golite062009 |
| transcription factor activity | 1.00126317233035 | bayes_pls_golite062009 |
| protein kinase activity | 0.956391533542429 | bayes_pls_golite062009 |
| transcription activator activity | 0.93417628414426 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.648647048549737 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.641170666751583 | bayes_pls_golite062009 |
| ubiquitin binding | 0.63951996057523 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.59326481279109 | bayes_pls_golite062009 |
| kinase activity | 0.533969592942037 | bayes_pls_golite062009 |
| small conjugating protein binding | 0.53318309637792 | bayes_pls_golite062009 |
| SMAD binding | 0.529987528306404 | bayes_pls_golite062009 |
| hydrolase activity | 0.34475558174039 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 0.313294193249444 | bayes_pls_golite062009 |
| transcription factor binding | 0.28405210686825 | bayes_pls_golite062009 |
| damaged DNA binding | 0.279328480488455 | bayes_pls_golite062009 |
| chromatin binding | 0.0581576861375597 | bayes_pls_golite062009 |
| protein dimerization activity | 0.0216801467872398 | bayes_pls_golite062009 |
|
Region A: Residues: [127-521] |
1 11 21 31 41 51
| | | | | |
1 QDEKRDAELP KKRMRKSNPG WENLEKLLVF TAAGVKPQGK VAGFDLDGTL ITTRSGKVFP 60
61 TGPSDWRILY PEIPRKLREL EAEGYKLVIF TNQMSIGRGK LPAEEFKAKV EAVVEKLGVP 120
121 FQVLVATHAG LYRKPVTGMW DHLQEQANDG TPISIGDSIF VGDAAGRPAN WAPGRKKKDF 180
181 SCADRLFALN LGLPFATPEE FFLKWPAAGF ELPAFDPRTV SRSGPLCLPE SRALLSASPE 240
241 VVVAVGFPGA GKSTFLKKHL VSAGYVHVNR DTLGSWQRCV TTCETALKQG KRVAIDNTNP 300
301 DAASRARYVQ CARAAGVPCR CFLFTATLEQ ARHNNRFREM TDSSHIPVSD MVMYGYRKQF 360
361 EAPTLAEGFS AILEIPFRLW VEPRLGRLYC QFSEG
|
| Detection Method: | |
| Confidence: | 72.30103 |
| Match: | 1yj5A |
| Description: | Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| phosphatase activity | 5.1741419126177 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 4.98288537099796 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 4.35132100394658 | bayes_pls_golite062009 |
| polynucleotide 3'-phosphatase activity | 3.35898650848577 | bayes_pls_golite062009 |
| nucleotide phosphatase activity | 2.90489006846175 | bayes_pls_golite062009 |
| hydrolase activity | 2.8454129466116 | bayes_pls_golite062009 |
| phosphoprotein phosphatase activity | 2.48898309484199 | bayes_pls_golite062009 |
| ATP-dependent polynucleotide kinase activity | 2.29319278342491 | bayes_pls_golite062009 |
| polydeoxyribonucleotide kinase activity | 2.29319278342491 | bayes_pls_golite062009 |
| polynucleotide kinase activity | 2.29319278342491 | bayes_pls_golite062009 |
| ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity | 2.29319278342491 | bayes_pls_golite062009 |
| catalytic activity | 1.55296860681783 | bayes_pls_golite062009 |
| nucleic acid binding | 1.03193813466144 | bayes_pls_golite062009 |
| binding | 0.89911057995199 | bayes_pls_golite062009 |
| DNA binding | 0.717646778444981 | bayes_pls_golite062009 |
| protein serine/threonine phosphatase activity | 0.438943767876088 | bayes_pls_golite062009 |
| inorganic cation transmembrane transporter activity | 0.399200517663665 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.365064688215173 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.35576808478553 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 0.353215187799141 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.289666831374877 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.269687349439947 | bayes_pls_golite062009 |
| kinase activity | 0.213470278166197 | bayes_pls_golite062009 |
