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Protein Overview: RDH54

General Information:
Name(s) found: RDH54 / YBR073W [SGD]
Description(s) found:
Found 16 descriptions.
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  • DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 924 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: reciprocal meiotic recombination [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    heteroduplex formation [IDALink to PubMed article]
    meiotic sister chromatid segregation [IMPLink to PubMed article]
    double-strand break repair via break-induced replication [TASLink to PubMed article]
    Molecular Function: DNA-dependent ATPase activity [IDALink to PubMed article]
    DNA topoisomerase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQIPKYENKP FKPPRRVGSN KYTQLKPTAT AVTTAPISKA KVTVNLKRSI SAGPTLNLAK  60
   61 KPNNLSSNEN TRYFTIMYRK PTTKKHKTWS GDGYATLKAS SDKLCFYNEA GKFLGSSMLP 120
  121 SDSDSLFETL FKAGSNEVQL DYELKENAEI RSAKEALSQN MGNPSPPTTS TTETVPSTKN 180
  181 DGGKYQMPLS QLFSLNTVKR FKSVTKQTNE HMTTVPKTSQ NSKAKKYYPV FDVNKIDNPI 240
  241 VMNKNAAAEV DVIVDPLLGK FLRPHQREGV KFMYDCLMGL ARPTIENPDI DCTTKSLVLE 300
  301 NDSDISGCLL ADDMGLGKTL MSITLIWTLI RQTPFASKVS CSQSGIPLTG LCKKILVVCP 360
  361 VTLIGNWKRE FGKWLNLSRI GVLTLSSRNS PDMDKMAVRN FLKVQRTYQV LIIGYEKLLS 420
  421 VSEELEKNKH LIDMLVCDEG HRLKNGASKI LNTLKSLDIR RKLLLTGTPI QNDLNEFFTI 480
  481 IDFINPGILG SFASFKRRFI IPITRARDTA NRYNEELLEK GEERSKEMIE ITKRFILRRT 540
  541 NAILEKYLPP KTDIILFCKP YSQQILAFKD ILQGARLDFG QLTFSSSLGL ITLLKKVCNS 600
  601 PGLVGSDPYY KSHIKDTQSQ DSYSRSLNSG KLKVLMTLLE GIRKGTKEKV VVVSNYTQTL 660
  661 DIIENLMNMA GMSHCRLDGS IPAKQRDSIV TSFNRNPAIF GFLLSAKSGG VGLNLVGRSR 720
  721 LILFDNDWNP SVDLQAMSRI HRDGQKKPCF IYRLVTTGCI DEKILQRQLM KNSLSQKFLG 780
  781 DSEMRNKESS NDDLFNKEDL KDLFSVHTDT KSNTHDLICS CDGLGEEIEY PETNQQQNTV 840
  841 ELRKRSTTTW TSALDLQKKM NEAATNDDAK KSQYIRQCLV HYKHIDPARQ DELFDEVITD 900
  901 SFTELKDSIT FAFVKPGEIC LREQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MNS1 RDH54 SIS2 TRM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RDH54 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] MSA 1.449995 View MSA. No confident structure predictions are available.
    2 View Details [186..254] deduced N/A No confident structure predictions are available.
    3 View Details [255..438] Pfam 4.721246 No description for PF00176.10 was found. No confident structure predictions are available.
    4 View Details [439..924] PSI-BLAST 34.522879 Structure of the RecQ Catalytic Core bound to ATP-gamma-S

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.02893949194171 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.97909493766908 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.95844964816653 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.95658009428828 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • ATPase activity
    		•  1.42257610975945 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • hydrolase activity
    		•  0.98565595572967 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.732723553251109 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.396187998943318 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.38363601832205 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.144154288308693 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • motor activity
    		•  0.0492172159259601 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle