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Protein Overview: TRM2

General Information:
Name(s) found: TRM2 / YKR056W [SGD]
Description(s) found:
Found 16 descriptions.
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  • tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 639 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: DNA repair [IGILink to PubMed article][IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    tRNA modification [IDALink to PubMed article]
    Molecular Function: double-stranded DNA specific 5'-3' exodeoxyribonuclease activity [IDALink to PubMed article]
    tRNA (m5U54) methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]
    single-stranded DNA specific endodeoxyribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYEQFEFSFF FFENSDNKVK YKAHLISSIK RWSIITCMRC FWTVQKSIFK ARFFACRNFV  60
   61 KKHNYKLIST MTGSTEMVPP TMKHTVDNKR LSSPLTDSGN RRTKKPKLRK YKAKKVETTS 120
  121 PMGVLEFEVN DLLKSQNLSR EQVLNDVTSI LNDKSSTDGP IVLQYHREVK NVKVLEITSN 180
  181 GNGLALIDNP VETEKKQVVI IPFGLPGDVV NIKVFKTHPY YVESDLLDVV EKSPMRRDDL 240
  241 IRDKYFGKSS GSQLEFLTYD DQLELKRKTI MNAYKFFAPR LVAEKLLPPF DTTVASPLQF 300
  301 GYRTKITPHF DMPKRKQKEL SVRPPLGFGQ KGRPQWRKDT LDIGGHGSIL DIDECVLATE 360
  361 VLNKGLTNER RKFEQEFKNY KKGATILLRE NTTILDPSKP TLEQLTEEAS RDENGDISYV 420
  421 EVEDKKNNVR LAKTCVTNPR QIVTEYVDGY TFNFSAGEFF QNNNSILPIV TKYVRDNLQA 480
  481 PAKGDDNKTK FLVDAYCGSG LFSICSSKGV DKVIGVEISA DSVSFAEKNA KANGVENCRF 540
  541 IVGKAEKLFE SIDTPSENTS VILDPPRKGC DELFLKQLAA YNPAKIIYIS CNVHSQARDV 600
  601 EYFLKETENG SAHQIESIRG FDFFPQTHHV ESVCIMKRI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MNS1 RDH54 SIS2 TRM2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] MSA 1.233938 View MSA. No confident structure predictions are available.
    2 View Details [166..639] PSI-BLAST 77.221849 Crystal Structure of RumA, the iron-sulfur cluster containing E. coli 23S Ribosomal RNA 5-Methyluridine Methyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  2.93712042261633 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  2.04350689362549 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  2.04350689362549 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  2.04218282227834 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  1.10713374933008 bayes_pls_golite062009
  • ligase activity
    		•  1.06979791212194 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.943661008731946 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.702449673647117 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596857566298868 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.504302440847948 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.449277083957511 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.40223812695012 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  0.250946859465502 bayes_pls_golite062009
  • rRNA (guanine-N1-)-methyltransferase activity
    		•  0.234572322347698 bayes_pls_golite062009
  • translation regulator activity
    		•  0.22908707234671 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  0.203168546434167 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.179682348023561 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.13299060447839 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle