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Protein Overview: HOS1

General Information:
Name(s) found: HOS1 / YPR068C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 470 amino acids

    Gene Ontology:
    Cellular Component: histone deacetylase complex [TASLink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [ISSLink to PubMed articleLink to PubMed article]
    protein amino acid deacetylation [ISSLink to PubMed articleLink to PubMed article]
    chromatin organization [ISSLink to PubMed articleLink to PubMed article]
    Molecular Function: histone deacetylase activity [ISSLink to PubMed articleLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP YARKDDLLEF  60
   61 HSKSYIDYLI NGRFNKMMAQ DVNNPMVESK WSELSELADN WNEKIDYNPS QDLQRFTTRE 120
  121 NLYNYYLNHS QALENNMDCI NNSEVPTNDK PTDTYILNSE TKQYNLEGDC PIFSYLPMYC 180
  181 QVITGATLNL LDHLSPTERL IGINWDGGRH HAFKQRASGF CYINDVVLLI QRLRKAKLNK 240
  241 ITYVDFDLHH GDGVEKAFQY SKQIQTISVH LYEPGFFPGT GSLSDSRKDK NVVNIPLKHG 300
  301 CDDNYLELIA SKIVNPLIER HEPEALIIEC GGDGLLGDRF NEWQLTIRGL SRIIINIMKS 360
  361 YPRAHIFLLG GGGYNDLLMS RFYTYLTWCV TKQFSNLRCG DNNSFQIDPF DVCDGDDSEQ 420
  421 FIREHDLVEM YNEENYQYWI YEMEGSSRMK MLRNDNKDRD MVELMKFYEL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) HDA1 HDA2 HDA3 HOS1 HOS4 HST1 PHO23 RPD3 SDS3 SET3 SIN3 SNT1 STB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A No confident structure predictions are available.
    2 View Details [75..238] PSI-BLAST 280.228787 HDAC homologue
    3 View Details [239..470] PSI-BLAST 280.228787 HDAC homologue

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein deacetylase activity
    		•  12.8220438463909 bayes_pls_golite062009
  • histone deacetylase activity
    		•  12.6231784270509 bayes_pls_golite062009
  • deacetylase activity
    		•  11.5037545953213 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  9.39837596691907 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  9.35288901670927 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05701986980927 bayes_pls_golite062009
  • hydrolase activity
    		•  2.48411098726406 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K27 specific)
    		•  2.32426965373744 bayes_pls_golite062009
  • histone deacetylase activity (H3-K16 specific)
    		•  2.32426965373744 bayes_pls_golite062009
  • transcription factor binding
    		•  2.19991964087943 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09632179671955 bayes_pls_golite062009
  • DNA binding
    		•  1.982290944939 bayes_pls_golite062009
  • binding
    		•  1.948738669065 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.86169983561723 bayes_pls_golite062009
  • protein binding
    		•  1.77599011146146 bayes_pls_golite062009
  • catalytic activity
    		•  1.68836803454021 bayes_pls_golite062009
  • transcription activator activity
    		•  1.31578100431097 bayes_pls_golite062009
  • transcription factor activity
    		•  1.24596588472933 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84972377395539 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.75415729284699 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
    		•  0.436815987851993 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.23239615682673 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  0.12704421781224 bayes_pls_golite062009
  • chromatin binding
    		•  0.104097933861351 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.50

    Source: Reynolds et al. (2008)

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