Protein Overview: CEX1

General Information:
Name(s) found:	CEX1 / YOR112W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74676602\|sp\|Q12453.1\|YO112_YEAST RecName: Full=Uncharacterized protein YOR112W [NCBI NR] gi\|6324686\|ref\|NP_014755.1\| Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p [NCBI NR] pir\|\|S60992 hypothetical protein YOR112w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420301\|emb\|CAA99310.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1164957\|emb\|CAA64032.1\| YOR3240w [Saccharomyces cerevisiae] [NCBI NR] gi\|1050818\|emb\|CAA62113.1\| ORF O3240 [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YOR112W OS=Saccharomyces cerevisiae GN=YOR112W PE=1 SV=1 [Swiss-Prot] Protein of unknown function localised to cytoplasm [mips] Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p [SGD] >Q12453 (Q12453) YOR3240W from chromosome XV [4932.FASTACCERV.txt] Chr XV from 531508-533793 [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 531507-533792 [yeastorf3.fasta] YOR112W, Chr XV from 531507-533792 [yeast_orfs2] YOR112W SGDID:S0005638, Chr XV from 531508-533793, Uncharacterized ORF [yeastflysequest.fasta] Yor112wp [Saccharomyces cerevisiae]gi\|1420301\|emb\|CAA99310.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1164957\|emb\|CAA64032.1\| YOR3240w [Saccharomyces cerevisiae]gi\|1050818\|emb\|CAA62113.1\| ORF O3240 [Saccharomyces cerevisiae]gi\|2132060\|pir [nrdb_11152004_Chlamydomonas] (Q12453) YOR3240w protein (ORF O3240 protein) (S.cerevisiae chromosome XV reading frame ORF YOR112w) [cerv4932.FASTAC] YOR112W SGDID:S000005638, Chr XV from 531508-533793, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YOR112W SGDID:S000005638, Chr XV from 531509-533794, Uncharacterized ORF, "Hypothetical protein" [yeast-contam.fasta] CEX1 SGDID:S000005638, Chr XV from 531509-533794, Verified ORF, "Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as we [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] YOR3240w [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Uncharacterized protein YOR112W [nr-271106-contam.fasta] hypothetical protein; Yor112wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ORF O3240 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CEX1 SGDID:S000005638, Chr XV from 531509-533794, Verified ORF, "Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] CEX1 SGDID:S000005638, Chr XV from 531508-533793, Genome Release 64-1-1, Verified ORF, "Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p" [yeast-030211-contam.fasta] CEX1 SGDID:S000005638, Chr XV from 531508-533793, Genome Release 64-2-1, Verified ORF, "Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex" [20141208_orf_trans.fasta] YOR112W SGDID:S000005638, Chr XV from 531508-533793, Genome Release 64-1-1, Verified ORF, "Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	761 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA ] nuclear pore [IDA][IPI]
Biological Process:	tRNA export from nucleus [IGI][IMP][IPI]
Molecular Function:	tRNA binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFSSIFKSI SNFQFPYTIE ETAITETALW QCFDGTRKAD SLPVTVFKAK RSPENESLIL  60
   61 NAVHKSKILK IPGLCTVLET FDSDPQSTFI VTERVVPFPW DNLGSLSQNK FGVELGISQL 120
  121 LATLGFLKNF VLGTLSKDSV FINIKGEWVL FGLELCSSKE GLSAFEFASR ARSYYNIIGS 180
  181 QLPCEDPNTI DSMGLGLLIK SLMAPSCLPK DWIVNVNMIS DGKITIENFR KRLENTETWR 240
  241 SNPLINFYQE LRELHIKDPQ GKLVVMSNLE NLYLESREIF RNLTPGMIEN FIIPELCEII 300
  301 KLLMTQSISS AASPIGMNFN ASHKLVPFLA IVLDLTSETN TFPVGFNDLI TQSFKLPDRQ 360
  361 VRFLLLIYLP KLIGPLSKSE ISSRIYPHFI QGLTDSDATL RLQTLKTIPC IVSCLTERQL 420
  421 NNELLRFLAK TQVDSDVEIR TWTVIIISKI STILSTSVGN RSNILATAFT KSLKDPQVKP 480
  481 RLAALYGLEK SIELFDVNTI ANKILTVIAP GLLDKSPIVR GRAKILFEEY LEKLEKEAQL 540
  541 IQTNDSTADS EDVKDIDFEN YGCDEEDMNK EDNLLAAQFL NNLRLNSPSA TTPSNITESE 600
  601 IDSAQDGSGW DDLSDTDGFI TNGTTESFDE TTNPVTTAST PKLFGKPIKI NKSWNDELND 660
  661 DGWIQDESGP SKVPQKHTRP QNSTLAKSIA PSSRLSIKKK KTTILAPRNI ASNSTVTTKS 720
  721 SLSNKTARSK PISSIRGSVT KKGNVDGWDD DGDSDSWDTN W

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CEX1 VMA6 VPH1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	CEX1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..94] [289..324]	PSI-BLAST	105.0	MAP kinase p38
2	View Details	[95..288]	PSI-BLAST	105.0	MAP kinase p38
3	View Details	[325..653]	PSI-BLAST	7.221849	Constant regulatory domain of protein phosphatase 2a, pr65alpha
4	View Details	[654..761]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: CEX1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: