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Protein Overview: CEX1

General Information:
Name(s) found: CEX1 / YOR112W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 761 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    nuclear pore [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: tRNA export from nucleus [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: tRNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFSSIFKSI SNFQFPYTIE ETAITETALW QCFDGTRKAD SLPVTVFKAK RSPENESLIL  60
   61 NAVHKSKILK IPGLCTVLET FDSDPQSTFI VTERVVPFPW DNLGSLSQNK FGVELGISQL 120
  121 LATLGFLKNF VLGTLSKDSV FINIKGEWVL FGLELCSSKE GLSAFEFASR ARSYYNIIGS 180
  181 QLPCEDPNTI DSMGLGLLIK SLMAPSCLPK DWIVNVNMIS DGKITIENFR KRLENTETWR 240
  241 SNPLINFYQE LRELHIKDPQ GKLVVMSNLE NLYLESREIF RNLTPGMIEN FIIPELCEII 300
  301 KLLMTQSISS AASPIGMNFN ASHKLVPFLA IVLDLTSETN TFPVGFNDLI TQSFKLPDRQ 360
  361 VRFLLLIYLP KLIGPLSKSE ISSRIYPHFI QGLTDSDATL RLQTLKTIPC IVSCLTERQL 420
  421 NNELLRFLAK TQVDSDVEIR TWTVIIISKI STILSTSVGN RSNILATAFT KSLKDPQVKP 480
  481 RLAALYGLEK SIELFDVNTI ANKILTVIAP GLLDKSPIVR GRAKILFEEY LEKLEKEAQL 540
  541 IQTNDSTADS EDVKDIDFEN YGCDEEDMNK EDNLLAAQFL NNLRLNSPSA TTPSNITESE 600
  601 IDSAQDGSGW DDLSDTDGFI TNGTTESFDE TTNPVTTAST PKLFGKPIKI NKSWNDELND 660
  661 DGWIQDESGP SKVPQKHTRP QNSTLAKSIA PSSRLSIKKK KTTILAPRNI ASNSTVTTKS 720
  721 SLSNKTARSK PISSIRGSVT KKGNVDGWDD DGDSDSWDTN W

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CEX1 VMA6 VPH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CEX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94]
    [289..324]    		 PSI-BLAST 105.0 MAP kinase p38
    2 View Details [95..288] PSI-BLAST 105.0 MAP kinase p38
    3 View Details [325..653] PSI-BLAST 7.221849 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    4 View Details [654..761] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.29841996497296 bayes_pls_golite062009
  • protein kinase activity
    		•  1.70731294943064 bayes_pls_golite062009
  • protein binding
    		•  1.62406684925162 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.53010383910925 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.52597476013849 bayes_pls_golite062009
  • kinase activity
    		•  1.46967868776426 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.20817899395165 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.13653556985891 bayes_pls_golite062009
  • receptor activity
    		•  1.13529255370019 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.940749450143365 bayes_pls_golite062009
  • transferase activity
    		•  0.876865688160088 bayes_pls_golite062009
  • signal transducer activity
    		•  0.814663047912932 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.814663047912932 bayes_pls_golite062009
  • ATP binding
    		•  0.80100967388643 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.766575848955892 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.755570176026019 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.718880569902791 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.718820382381459 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.715416129764882 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.71378093587622 bayes_pls_golite062009
  • nucleotide binding
    		•  0.708369770220977 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • catalytic activity
    		•  0.673946834085468 bayes_pls_golite062009
  • nucleocytoplasmic transporter activity
    		•  0.543805639050221 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.41304985993342 bayes_pls_golite062009
  • RNA binding
    		•  0.180581540285588 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle