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Protein Overview: INP54

General Information:
Name(s) found: INP54 / YOL065C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 384 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: inositol lipid-mediated signaling [TASLink to PubMed article]
    exocytosis [TASLink to PubMed article]
    phosphoinositide dephosphorylation [TASLink to PubMed article]
    Molecular Function: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKTNWKVSV TTFNCGKEFP VENSKAIVKQ LLFPYDDGIS QLELQDLYVL GFQEVVPIWQ  60
   61 GSFPAVNRDL IDRITTTAVN CLNEKVSATQ GDEQYSCLGV NSLGAITIIV LYNNNALKVK 120
  121 DDILKRNGKC GWFGTHLKGG TLISFQMTRN GEENWERFSY ICAHLNANEG VNNRNQRIDD 180
  181 YKRIMSEVCD SEVAKSDHFF FLGDLNFRVT STYDPTTNYS STTTLRRLLE NHEELNLLRK 240
  241 GEDEPLCKGF QELKITFPPT YKFKLFEKET YNTKRIPSWC DRILYKSYAV PTFAQEGTYH 300
  301 SVPRSNALLF SDHQPVNLTV RLPRSTGTPV PLSLHIEKYP LSWSSGLIGQ IGDAVIGYCG 360
  361 WLVTKNVHYW ILGSLLLYLL LKIL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAP1 DFR1 INP54

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen INP54 PHO86 2 Unpublished Fields Lab Data
    View Screen INP54 SPC1 2 Unpublished Fields Lab Data
    View Screen INP54 NUP53 2 Unpublished Fields Lab Data
    View Screen INP54 YNL146W 1 Unpublished Fields Lab Data
    View Screen INP54 PRM3 1 Unpublished Fields Lab Data
    View Screen CDC53 INP54 1 Unpublished Fields Lab Data
    View Screen VAM7 INP54 1 Unpublished Fields Lab Data
    View Screen YPT35 INP54 1 Unpublished Fields Lab Data
    View Screen INP54 PHO89 1 Unpublished Fields Lab Data
    View Screen INP54 SNF11 1 Unpublished Fields Lab Data
    View Screen INP54 YGL102C 1 Unpublished Fields Lab Data
    View Screen INP54 POP6 1 Unpublished Fields Lab Data
    View Screen INP54 AIM18 1 Unpublished Fields Lab Data
    View Screen INP54 AIR1 1 Unpublished Fields Lab Data
    View Screen INP54 KTR7 1 Unpublished Fields Lab Data
    View Screen INP54 YKL053W 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..384] PSI-BLAST 295.522879 Synaptojanin, IPP5C domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  5.89224335840239 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  5.76202422677892 bayes_pls_golite062009
  • phosphoinositide 5-phosphatase activity
    		•  5.57319461575586 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
    		•  5.57319461575586 bayes_pls_golite062009
  • phosphatase activity
    		•  5.52443562029354 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  5.46652892688189 bayes_pls_golite062009
  • hydrolase activity
    		•  4.46212165555307 bayes_pls_golite062009
  • inositol-polyphosphate 5-phosphatase activity
    		•  4.20215185632047 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  3.88924621938812 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  3.07322777760243 bayes_pls_golite062009
  • inositol trisphosphate phosphatase activity
    		•  2.32855198081691 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  1.98439062808392 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • phosphatidylinositol-4-phosphate phosphatase activity
    		•  1.01103192743992 bayes_pls_golite062009
  • phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
    		•  1.01103192743992 bayes_pls_golite062009
  • binding
    		•  0.959085129941521 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  0.731013770154616 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
    		•  0.558149994726796 bayes_pls_golite062009
  • protein binding
    		•  0.422499345963305 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.134524000856626 bayes_pls_golite062009
  • nuclease activity
    		•  0.133817887861564 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle