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View Structure Prediction Details

Protein: INP54
Organism: Saccharomyces cerevisiae
Length: 384 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INP54.

Description E-value Query
Range		 Subject
Range
INP54 - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endop...
INP54_YEAST - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54 OS=Saccharomyces cerevisiae (strain ATCC 2...
 0.0 [1..371] [1..371]
gi|9937209 - gi|9937209|gb|AAG02341.1|AF205939_1 synaptojanin 1 [Lampetra fluviatilis]
 0.0 [4..354] [538..894]
gi|3241989 - gi|3241989|gb|AAC40143.1| synaptojanin 2 isoform epsilon [Mus musculus]
 0.0 [2..319] [180..515]
gi|16647984 - gi|16647984|gb|AAK61722.1| synaptojanin 2B1 [Rattus norvegicus]
 0.0 [2..319] [543..878]
SYNJ2 - synaptojanin 2
gi|168272964 - gi|168272964|dbj|BAG10321.1| synaptojanin-2 [synthetic construct]
 0.0 [2..319] [473..808]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [2..319] [441..776]

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Predicted Domain #1
Region A:
Residues: [1-384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKTNWKVSV TTFNCGKEFP VENSKAIVKQ LLFPYDDGIS QLELQDLYVL GFQEVVPIWQ  60
   61 GSFPAVNRDL IDRITTTAVN CLNEKVSATQ GDEQYSCLGV NSLGAITIIV LYNNNALKVK 120
  121 DDILKRNGKC GWFGTHLKGG TLISFQMTRN GEENWERFSY ICAHLNANEG VNNRNQRIDD 180
  181 YKRIMSEVCD SEVAKSDHFF FLGDLNFRVT STYDPTTNYS STTTLRRLLE NHEELNLLRK 240
  241 GEDEPLCKGF QELKITFPPT YKFKLFEKET YNTKRIPSWC DRILYKSYAV PTFAQEGTYH 300
  301 SVPRSNALLF SDHQPVNLTV RLPRSTGTPV PLSLHIEKYP LSWSSGLIGQ IGDAVIGYCG 360
  361 WLVTKNVHYW ILGSLLLYLL LKIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 295.522879
Match: 1i9yA_
Description: Synaptojanin, IPP5C domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 5.89224335840239 bayes_pls_golite062009
phosphatidylinositol bisphosphate phosphatase activity 5.76202422677892 bayes_pls_golite062009
phosphoinositide 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
phosphatase activity 5.52443562029354 bayes_pls_golite062009
phosphoric ester hydrolase activity 5.46652892688189 bayes_pls_golite062009
hydrolase activity 4.46212165555307 bayes_pls_golite062009
inositol-polyphosphate 5-phosphatase activity 4.20215185632047 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 3.88924621938812 bayes_pls_golite062009
lipid phosphatase activity 3.07322777760243 bayes_pls_golite062009
inositol trisphosphate phosphatase activity 2.32855198081691 bayes_pls_golite062009
phosphatidylinositol-3-phosphatase activity 1.98439062808392 bayes_pls_golite062009
catalytic activity 1.76511376991978 bayes_pls_golite062009
phosphatidylinositol-4-phosphate phosphatase activity 1.01103192743992 bayes_pls_golite062009
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity 1.01103192743992 bayes_pls_golite062009
binding 0.959085129941521 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 0.731013770154616 bayes_pls_golite062009
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity 0.558149994726796 bayes_pls_golite062009
protein binding 0.422499345963305 bayes_pls_golite062009
deoxyribonuclease activity 0.134524000856626 bayes_pls_golite062009
nuclease activity 0.133817887861564 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle