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Protein Overview: SQS1

General Information:
Name(s) found: SQS1 / YNL224C [SGD]
Description(s) found:
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  • gi|6324105|ref|NP_014175.1| Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; Sqs1p [Saccharomyces [NCBI NR]
  • pir||S63182 hypothetical protein YNL224c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730825|sp|P53866.1|SQS1_YEAST RecName: Full=Protein SQS1; AltName: Full=Squelch of splicing suppression protein 1 [NCBI NR]
  • gi|1302245|emb|CAA96127.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1183990|emb|CAA93374.1| N1269 [Saccharomyces cerevisiae] [NCBI NR]
  • Uncharacterized protein YNL224C - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot]
  • Protein SQS1 OS=Saccharomyces cerevisiae GN=SQS1 PE=1 SV=1 [Swiss-Prot]
  • Protein of unknown function localised to cytoplasm and nucleus [mips]
  • Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles [SGD]
  • Chr XIV from 224795-227098, reverse complement [yeastorf3.fasta]
  • Chr XIV from 227098-224795, reverse complement [yeastorf5.fasta]
  • (P53866) Hypothetical 86.9 kDa protein in URE2-SSU72 intergenic region [4932.FASTACCERV.txt]
  • YNL224C, Chr XIV from 224795-227098, reverse complement [yeast_orfs2]
  • YNL224C SGDID:S0005168, Chr XIV from 227098-224795, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Ynl224cp [Saccharomyces cerevisiae]gi|1183990|emb|CAA93374.1| N1269 [Saccharomyces cerevisiae]gi|1302245|emb|CAA96127.1| unnamed protein product [Saccharomyces cerevisiae]gi|1730825|sp|P53866|YNW4_YEAST Hypothetical 86.9 kDa protein in URE2-SSU72 inter [nrdb_11152004_Chlamydomonas]
  • YNL224C SGDID:S000005168, Chr XIV from 227100-224797, reverse complement, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SQS1 SGDID:S000005168, Chr XIV from 227100-224797, reverse complement, Verified ORF, "Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes t [yeast-contam.fasta]
  • Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; Sqs1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • N1269 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Hypothetical 86.9 kDa protein in URE2-SSU72 intergenic region [nr-271106-contam.fasta]
  • SQS1 SGDID:S000005168, Chr XIV from 227100-224797, reverse complement, Verified ORF, "Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splici [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • SQS1 SGDID:S000005168, Chr XIV from 227100-224797, reverse complement, Verified ORF, "Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • SQS1 SGDID:S000005168, Chr XIV from 227100-224797, reverse complement, Verified ORF, "Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles" [SGDyeast.20101221.fasta]
  • Protein SQS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SQS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SQS1 SGDID:S000005168, Chr XIV from 227099-224796, Genome Release 64-1-1, reverse complement, Verified ORF, "Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles" [yeast-030211-contam.fasta]
  • SQS1 SGDID:S000005168, Chr XIV from 227099-224796, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress" [20141208_orf_trans.fasta]
  • YNL224C SGDID:S000005168, Chr XIV from 227099-224796, Genome Release 64-1-1, reverse complement, Verified ORF, "Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 767 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRHSHYQG SRRRHARGSN SKKAGRGNAK GIQGRKIKKK PTPTNSWHNS SIPLGEGDLD  60
   61 DVGADFNPGR AFISPKTIED YYFGRDAKSR SMKMGGLRPG NRYDSSTDLQ AGRAAFRKRP 120
  121 MQFVKAKEVY DPSHNMIQKL RAKNETKNSE EIVEREADVF EEPGKMTSDV EYINNEDSEN 180
  181 EDDDSQNSPS TDHSLSSNES KVEDGDLFFV DEEAQQSPDL TKIKRVCIEE IARPREVAIE 240
  241 FDPILTIGKV ELSVSEGNES KEISVDVPNK GNKTYHPFAG YISNVLHGMH TSDSDNDELD 300
  301 YEIETENNSE PLYESSASSE VDQGFNYVGQ RHNSRADNNL LPSPSPQLTE DIKCLSINGT 360
  361 KTFEGNNDNL PSPASEELEF GFKEEDFVIN TNDIVVSNIR MGGVDNSYYL RCYRLLGDYD 420
  421 FHWIDQDLLT DFVVDELGLP EDRLPAYLNF IKNSLIPKIE PAEPTYSDIP ISDSSDEGDS 480
  481 YEGDSYEDDE DMASSVVHSD IEEGLDDLIA YTLKHDTERF KTFETKSLET KGKGKKKKLL 540
  541 IDDALALDTE TLETLQSKFS KRIETKAKKR KAKEDFIDQE NRNSNDMLKK YPYGLHIQNI 600
  601 KDEFESFLSR NNDRLTFPPL DPHGNKTVMK IAKHYNMKSS KIGKANHTSV VVEKIKKTKW 660
  661 SSPNYSLIDQ LMRQRPVFMR IDIRRPREEQ AAFERTKTIR GKFHVKEGEI VGQNAPEIGN 720
  721 ENIGRRMLEK LGWKSGEGLG IQGNKGISEP IFAKIKKNRS GLRHSES

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CWC23 PRP43 SQS1
    View Details Krogan NJ, et al. (2006) CWC23 PRP43 SPP382 SQS1
    View Details Gavin AC, et al. (2006) PRP43 SQS1
    View Details Gavin AC, et al. (2002) ASC1 CDC33 CLF1 CWC23 DCP2 DHH1 DIB1 ERB1 KRS1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 NAM7 NOG2 NOP1 NUG1 PAT1 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 SMB1 SMD2 SNU114 SNU23 SNU66 SPP382 SQS1 SRO9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SQS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..307] MSA 1.002856 View MSA. No confident structure predictions are available.
    2 View Details [308..371] deduced N/A No confident structure predictions are available.
    3 View Details [372..718] MSA 1.075997 View MSA. No confident structure predictions are available.
    4 View Details [719..767] Pfam 16.376751 G-patch domain No confident structure predictions are available.
    5 View Details [531..683] FFAS03 1.38 SmuBP-2
    6 View Details [684..767] MSA 50.185997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • DNA binding
    		•  1.50596754488506 bayes_pls_golite062009
  • binding
    		•  1.49983036545301 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46911563206977 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.40070005217107 bayes_pls_golite062009
  • catalytic activity
    		•  0.307971467423079 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.104498084588774 bayes_pls_golite062009
  • protein binding
    		•  0.0446628977860376 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle