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View Structure Prediction Details

Protein: SQS1
Organism: Saccharomyces cerevisiae
Length: 767 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SQS1.

Description E-value Query
Range
Subject
Range
SQS1 - Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA matu...
SQS1_YEAST - Protein SQS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SQS1 PE=1 SV=1
0.0 [1..767] [1..767]
gi|1613900 - gi|1613900|gb|AAB42216.1| partial CDS, human putative tumor suppressor (U23946) [Homo sapiens]
1.0E-74 [466..767] [363..672]
RBM5_MOUSE - RNA-binding protein 5 OS=Mus musculus GN=Rbm5 PE=1 SV=1
5.0E-71 [466..767] [480..789]
RBM10_RAT - RNA-binding protein 10 OS=Rattus norvegicus GN=Rbm10 PE=1 SV=1
7.0E-69 [466..767] [512..826]

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Predicted Domain #1
Region A:
Residues: [1-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRHSHYQG SRRRHARGSN SKKAGRGNAK GIQGRKIKKK PTPTNSWHNS SIPLGEGDLD  60
   61 DVGADFNPGR AFISPKTIED YYFGRDAKSR SMKMGGLRPG NRYDSSTDLQ AGRAAFRKRP 120
  121 MQFVKAKEVY DPSHNMIQKL RAKNETKNSE EIVEREADVF EEPGKMTSDV EYINNEDSEN 180
  181 EDDDSQNSPS TDHSLSSNES KVEDGDLFFV DEEAQQSPDL TKIKRVCIEE IARPREVAIE 240
  241 FDPILTIGKV ELSVSEGNES KEISVDVPNK GNKTYHPFAG YISNVLHGMH TSDSDNDELD 300
  301 YEIETEN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [308-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSEPLYESSA SSEVDQGFNY VGQRHNSRAD NNLLPSPSPQ LTEDIKCLSI NGTKTFEGNN  60
   61 DNLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [372-718]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPASEELEFG FKEEDFVINT NDIVVSNIRM GGVDNSYYLR CYRLLGDYDF HWIDQDLLTD  60
   61 FVVDELGLPE DRLPAYLNFI KNSLIPKIEP AEPTYSDIPI SDSSDEGDSY EGDSYEDDED 120
  121 MASSVVHSDI EEGLDDLIAY TLKHDTERFK TFETKSLETK GKGKKKKLLI DDALALDTET 180
  181 LETLQSKFSK RIETKAKKRK AKEDFIDQEN RNSNDMLKKY PYGLHIQNIK DEFESFLSRN 240
  241 NDRLTFPPLD PHGNKTVMKI AKHYNMKSSK IGKANHTSVV VEKIKKTKWS SPNYSLIDQL 300
  301 MRQRPVFMRI DIRRPREEQA AFERTKTIRG KFHVKEGEIV GQNAPEI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [719-767]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNENIGRRML EKLGWKSGEG LGIQGNKGIS EPIFAKIKKN RSGLRHSES

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 16.376751
Match: PF01585
Description: G-patch domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [531-683]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGKGKKKKLL IDDALALDTE TLETLQSKFS KRIETKAKKR KAKEDFIDQE NRNSNDMLKK  60
   61 YPYGLHIQNI KDEFESFLSR NNDRLTFPPL DPHGNKTVMK IAKHYNMKSS KIGKANHTSV 120
  121 VVEKIKKTKW SSPNYSLIDQ LMRQRPVFMR IDI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.38
Match: 1mszA
Description: SmuBP-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 1.50596754488506 bayes_pls_golite062009
binding 1.49983036545301 bayes_pls_golite062009
nucleic acid binding 1.46911563206977 bayes_pls_golite062009
transcription regulator activity 1.40070005217107 bayes_pls_golite062009
catalytic activity 0.307971467423079 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.104498084588774 bayes_pls_golite062009
protein binding 0.0446628977860376 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [684-767]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRPREEQAAF ERTKTIRGKF HVKEGEIVGQ NAPEIGNENI GRRMLEKLGW KSGEGLGIQG  60
   61 NKGISEPIFA KIKKNRSGLR HSES

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle