Protein Overview: NGL2

General Information:
Name(s) found:	NGL2 / YMR285C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|825551\|emb\|CAA89783.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323941\|ref\|NP_014012.1\| Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p; Ngl2p [Saccharomyces cerevisiae] [NCBI NR] gi\|2497217\|sp\|Q03264.1\|NGL2_YEAST RecName: Full=RNA exonuclease NGL2; AltName: Full=Carbon catabolite repressor protein 4 homolog [NCBI NR] pir\|\|S54592 hypothetical protein YMR285c - yeast (Saccharomyces cerevisiae) [NCBI NR] (Q03264) Hypothetical 59.5 kDa protein in HDF1-MRPL33 intergenic region [Swiss-Prot] RNA exonuclease NGL2 OS=Saccharomyces cerevisiae GN=NGL2 PE=1 SV=1 [Swiss-Prot] NGL2 RNase required for correct 3`-end formation of 5.8S rRNA at site E [mips] Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p [SGD] NGL2, Chr XIII from 840144-841691, reverse complement [yeast_orfs2] Chr XIII from 840144-841691, reverse complement [yeastorf3.fasta] Chr XIII from 841691-840144, reverse complement [yeastorf5.fasta] NGL2 SGDID:S0004898, Chr XIII from 841690-840143, reverse complement, Verified ORF [yeastflysequest.fasta] Ngl2p [Saccharomyces cerevisiae]gi\|825551\|emb\|CAA89783.1\| unknown [Saccharomyces cerevisiae]gi\|2497217\|sp\|Q03264\|YM8O_YEAST Hypothetical 59.5 kDa protein in HDF1-MRPL33 intergenic regiongi\|1078537\|pir\|\|S54592 hypothetical protein YMR285c - yeast (Sacch [nrdb_11152004_Chlamydomonas] NGL2 SGDID:S000004898, Chr XIII from 841690-840143, reverse complement, Verified ORF, "Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] RNA exonuclease NGL2 (Carbon catabolite repressor protein 4 homolog) [nr-271106-contam.fasta] Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p; Ngl2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] RNA exonuclease NGL2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NGL2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] NGL2 SGDID:S000004898, Chr XIII from 841691-840144, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p" [yeast-030211-contam.fasta] NGL2 SGDID:S000004898, Chr XIII from 841691-840144, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YMR285C SGDID:S000004898, Chr XIII from 841691-840144, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	515 amino acids
Gene Ontology:
Cellular Component:	intracellular [IDA]
Biological Process:	rRNA processing [IMP]
Molecular Function:	endoribonuclease activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQDKEVKVV APDVAPDQEV EINKSVKDAK HQTNDDSLLQ HKKKGKKGKK SKPIVTPEHI  60
   61 AKVRAEREVM RKAKRDAMLA QGVDPDCPPE LHFIRRPFLS LHEAEPVTGF RFKLMTYNCL 120
  121 AQALIRRKLF PDSGDALKWY RRSKVLLNEF KYYNSDVICL QEIDHIQFQS FWKDEFSKLG 180
  181 YDGQYYRNAT KNHGVAIMWR RELFHQVDKM LIDYDKESSE SISTRTTTNN VGLVLALKFS 240
  241 EKVLSNLGKK SSKKCGILIG TTHLFWHPFG TYERTRQCYI VLKKMKEFMH RVNVLQNEND 300
  301 GDLSHWFPFF CGDFNSQPFD TPYLSMTSKP VHYRNRAKTV IGCSTSYKFS KVRDGEEGAD 360
  361 DEEGGNIEKY GKDQPESPVP EKFHANEEQS ELVDKMAQLH NSLDMRAISL YSVGYKNVHP 420
  421 ENAGLDNDRG EPEISNWANT WRGLLDYLFY VKKWDPQSNC QEVETLGDFE KENKVKCRGF 480
  481 LRMPPGNEMT KHGQPHVGEY ASDHLSMVCD LELQL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ACC1 ACH1 ADH2 ADR1 GCD11 GFA1 GND1 GUS1 IDH2 ISA2 MDH1 MET18 NGL2 PYC1 PYC2 RET1 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN3 RPO26 RPO31 RVS167 SEC27 TBS1 TFP1 TSA2 YFL042C YHR112C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	NGL2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..358]	PSI-BLAST	23.30103	DNA repair endonuclease Hap1
2	View Details	[359..515]	MSA	1.058983	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: NGL2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: