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Protein Overview: NDI1

General Information:
Name(s) found: NDI1 / YML120C [SGD]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 513 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article][IMPLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: mitochondrial electron transport, NADH to ubiquinone [IDALink to PubMed article]
    positive regulation of apoptosis [IMPLink to PubMed article]
    NADH oxidation [IDALink to PubMed article]
    chronological cell aging [IMPLink to PubMed article]
    Molecular Function: NADH dehydrogenase (ubiquinone) activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSKNLYSNK RLLTSTNTLV RFASTRSTGV ENSGAGPTSF KTMKVIDPQH SDKPNVLILG  60
   61 SGWGAISFLK HIDTKKYNVS IISPRSYFLF TPLLPSAPVG TVDEKSIIEP IVNFALKKKG 120
  121 NVTYYEAEAT SINPDRNTVT IKSLSAVSQL YQPENHLGLH QAEPAEIKYD YLISAVGAEP 180
  181 NTFGIPGVTD YGHFLKEIPN SLEIRRTFAA NLEKANLLPK GDPERRRLLS IVVVGGGPTG 240
  241 VEAAGELQDY VHQDLRKFLP ALAEEVQIHL VEALPIVLNM FEKKLSSYAQ SHLENTSIKV 300
  301 HLRTAVAKVE EKQLLAKTKH EDGKITEETI PYGTLIWATG NKARPVITDL FKKIPEQNSS 360
  361 KRGLAVNDFL QVKGSNNIFA IGDNAFAGLP PTAQVAHQEA EYLAKNFDKM AQIPNFQKNL 420
  421 SSRKDKIDLL FEENNFKPFK YNDLGALAYL GSERAIATIR SGKRTFYTGG GLMTFYLWRI 480
  481 LYLSMILSAR SRLKVFFDWI KLAFFKRDFF KGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Qiu et al. (2008) AIF1 ALD4 ATP1 ATP2 COX5A COX5B COX7 CYB2 CYC7 CYT1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 RPM2 SDH1 SDH4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ELM1 NDI1 1 Unpublished Fields Lab Data
    View Screen CNB1 NDI1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NDI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..179]
    [341..513]    		 PSI-BLAST 101.0 Dihydrolipoamide dehydrogenase
    2 View Details [180..340] PSI-BLAST 101.0 Dihydrolipoamide dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on NADH or NADPH
    		•  6.80483427531026 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.24087829378489 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.57282017498189 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.50603438449246 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.3998060954585 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.35426029070392 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.28982462439281 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.19095357354283 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.17217047087399 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  1.6187224316494 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.59912481901166 bayes_pls_golite062009
  • catalytic activity
    		•  1.56773888754354 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.45104542724719 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.31328088143083 bayes_pls_golite062009
  • protein binding
    		•  1.16738144711505 bayes_pls_golite062009
  • binding
    		•  0.993436593091194 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.7227919966299 bayes_pls_golite062009
  • coenzyme binding
    		•  0.146916113354806 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  0.110826254138262 bayes_pls_golite062009
  • cofactor binding
    		•  0.0578189575854124 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.0194702205549504 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle