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Protein Overview: UFO1

General Information:
Name(s) found: UFO1 / YML088W [SGD]
Description(s) found:
Found 24 descriptions.
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  • F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 668 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    SCF ubiquitin ligase complex [IPILink to PubMed article]
    Biological Process: response to DNA damage stimulus [IMPLink to PubMed article][IPILink to PubMed article]
    ubiquitin-dependent protein catabolic process [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IMPLink to PubMed article]
    protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPGLVLQD LPPEILINIF SHLDEKDLFT LQELSTHFRN LIHDEELWKN LFKSRVHTTH  60
   61 FPTFSQSSKF SVEYIERTRG LHHWQHNKAI RTKYTIIPTR NWDQPSIERI VFDYPRVAAY 120
  121 NDGTITILQL QNHKRQKKFK KLIYIPCTTP QGCSTMDFNI NAAVFGRFDG RVFGKLLSNK 180
  181 SYLTPVMEFT GRHSAGVTAI CNSESWDTSR EDWSVSGSEN GEIIWWCENK LVKMWKVSNR 240
  241 VIWKLAFFKD WTLIMDDEKL YIIHQMQELH SIDIPKDLDE QPMRVRFFKM DFGSMTLVLA 300
  301 DLNNVYTISV NPNGNFGNLR KLEMPEQICA VEIDEKTSQR EQNWQFAGDD GCYISLLTTQ 360
  361 NTLYIINIRD LSSSGLKVQC KISFDEQVYV SQVTNLIVVV ALPNVLQILN AMTGELIKTV 420
  421 LKTEKFPEFL KVSQDKIIMG SGNVLNYLKF VSSDSKKHHH STKGKNTVSN KWNETLNTEL 480
  481 QYYDEDEDLR RKRQSEISRL IDAYGGDLEL SGDTDEENDI QLRIALLESQ EAQARNQAEA 540
  541 GEPVGDDEDE QLRRALEESQ LIYETQTNSS ANHGNNTNDE IDEDDEEFLR AIRQSRVEDE 600
  601 RRRHLRNHTT GRRNGPLSDD NFATYGAAES SERTSTENTI GSSVGVDASN NVDEDLQLAI 660
  661 ALSLSEIN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) BOP2 CDC4 CDC53 PRB1 SGT1 SKP1 UFO1 YDR131C
    View Details Qiu et al. (2008) CDC53 GRR1 HRT1 HRT3 MET30 SKP1 UFO1 YNL311C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ROM1 UFO1 2 Unpublished Fields Lab Data
    View Screen SKP1 UFO1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UFO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 14.221849 Skp2; Cyclin A/CDK2-associated p19, Skp2
    2 View Details [103..349] PSI-BLAST 20.0 Tup1, C-terminal domain
    3 View Details [350..668] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

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