YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: APT1

General Information:
Name(s) found: APT1 / YML022W [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 187 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: AMP biosynthetic process [TASLink to PubMed article]
    adenine salvage [IMPLink to PubMed article]
    Molecular Function: adenine phosphoribosyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIASYAQEL KLALHQYPNF PSEGILFEDF LPIFRNPGLF QKLIDAFKLH LEEAFPEVKI  60
   61 DYIVGLESRG FLFGPTLALA LGVGFVPVRK AGKLPGECFK ATYEKEYGSD LFEIQKNAIP 120
  121 AGSNVIIVDD IIATGGSAAA AGELVEQLEA NLLEYNFVME LDFLKGRSKL NAPVFTLLNA 180
  181 QKEALKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) APT1 ARO1 DSS1 ECM10 MTC5 OYE2 PRE1 PST2 PUP3 SOD2 TMA29 TPS1 TSA2 YHR033W YKU80
    View Details Qiu et al. (2008) APT1 EMG1 HPT1 RKI1 RPL11A RPL12B, RPL12A RPL14A RPL16A RPL19B, RPL19A RPL1A, RPL1B RPL20A RPL20B RPL21B RPL23B, RPL23A RPL26A RPL26B RPL27B RPL2A, RPL2B RPL34A RPL35A, RPL35B RPL37A RPL40B, RPL40A RPL42B, RPL42A RPL5 RPL6B RPL8A RPL8B RPL9B RPP1A RPP2A RPS0A RPS0B RPS10A RPS14B RPS16B, RPS16A RPS1B RPS22A RPS23B, RPS23A RPS25B RPS26B RPS28A RPS29A RPS29B RPS6A, RPS6B RPS7B RPS8B, RPS8A URA5 YNL010W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPT21 APT1 1 Unpublished Fields Lab Data
    View Screen APC5 APT1 1 Unpublished Fields Lab Data
    View Screen SEC17 APT1 1 Unpublished Fields Lab Data
    View Screen HNT2 APT1 1 Unpublished Fields Lab Data
    View Screen RAD54 APT1 1 Unpublished Fields Lab Data
    View Screen RNR3 APT1 1 Unpublished Fields Lab Data
    View Screen RAD26 APT1 1 Unpublished Fields Lab Data
    View Screen STE3 APT1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data APT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] PSI-BLAST 932.9794 Adenine PRTase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenine phosphoribosyltransferase activity
    		•  4.07252508868782 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  3.91023158228049 bayes_pls_golite062009
  • hypoxanthine phosphoribosyltransferase activity
    		•  3.89356447922614 bayes_pls_golite062009
  • transferase activity
    		•  3.88709784255536 bayes_pls_golite062009
  • transferase activity, transferring pentosyl groups
    		•  2.53679639481311 bayes_pls_golite062009
  • uracil phosphoribosyltransferase activity
    		•  2.36237864658341 bayes_pls_golite062009
  • catalytic activity
    		•  2.30431811394775 bayes_pls_golite062009
  • amidophosphoribosyltransferase activity
    		•  1.6596316647688 bayes_pls_golite062009
  • ribose phosphate diphosphokinase activity
    		•  1.51875493459374 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.45489477082258 bayes_pls_golite062009
  • purine binding
    		•  1.3774977535406 bayes_pls_golite062009
  • nucleobase binding
    		•  1.28671115202467 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.09798789282825 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.07284130528063 bayes_pls_golite062009
  • DNA binding
    		•  0.854593555814443 bayes_pls_golite062009
  • adenine binding
    		•  0.817887117933035 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  0.749909396904601 bayes_pls_golite062009
  • binding
    		•  0.691442295634288 bayes_pls_golite062009
  • transcription factor activity
    		•  0.339219342075596 bayes_pls_golite062009
  • orotate phosphoribosyltransferase activity
    		•  0.148898393751978 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle