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Protein Overview: CCC1

General Information:
Name(s) found: CCC1 / YLR220W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 322 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [ISSLink to PubMed article]
    fungal-type vacuole membrane [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IGILink to PubMed article][IMPLink to PubMed article]
    cellular manganese ion homeostasis [IGILink to PubMed article][IMPLink to PubMed article]
    cellular calcium ion homeostasis [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: manganese ion transmembrane transporter activity [IMPLink to PubMed article]
    ferrous iron transmembrane transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIVALKNAV VTLIQKAKGS GGTSELGGSE STPLLRGSNS NSSRHDNLSS SSSDIIYGRN  60
   61 SAQDLENSPM SVGKDNRNGD NGSDNEKANL GFFQSVDPRV ISDLIIGLSD GLTVPFALTA 120
  121 GLSSLGDAKL VITGGFAELI SGAISMGLGG YLGAKSESDY YHAEVKKEKR KFYDNSNLIN 180
  181 REIEDILLEI NPNFSDETIV SFIKDLQRTP ELMVDFIIRY GRGLDEPAEN RELISAVTIG 240
  241 GGYLLGGLVP LVPYFFVSDV GTGLIYSIIV MVVTLFWFGY VKTKLSMGSG SSTSKKVTEG 300
  301 VEMVVVGGVA AGAAWFFVKL LG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ATX2 CCC1 COT1 PMC1 SMF3 VCX1 VMA9 ZRC1 ZRT3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CCC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [79..322] Pfam 3.026872 Integral membrane protein DUF125 No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle