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Protein Overview: COT1

General Information:
Name(s) found: COT1 / YOR316C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 439 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    Biological Process: cobalt ion transport [IMPLink to PubMed article]
    zinc ion transport [IGILink to PubMed article]
    cellular zinc ion homeostasis [IMPLink to PubMed article]
    Molecular Function: cobalt ion transmembrane transporter activity [IMPLink to PubMed article]
    zinc ion transmembrane transporter activity [IGILink to PubMed article]
    di-, tri-valent inorganic cation transmembrane transporter activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLGSKQVKI ISLLLLDTVF FGIEITTGYL SHSLALIADS FHMLNDIISL VVALWAVNVA  60
   61 KNRNPDSTYT YGWKRAEILG ALINAVFLIA LCVSILIEAL QRIIAPPVIE NPKFVLYVGV 120
  121 AGLISNTVGL FLFHDNDQEH GHGHGHSHGG IFADHEMHMP SSHTHTHAHV DGIENTTPMD 180
  181 STDNISEIMP NAIVDSFMNE NTRLLTPENA SKTPSYSTSS HTIASGGNYT EHNKRKRSLN 240
  241 MHGVFLHVLG DALGNIGVML SAFFIWKTDY SWKYYTDPLV SLIITGIIFS SALPLSCKAS 300
  301 KILLQATPST LSGDQVEGDL LKIPGIIAIH DFHIWNLTES IFIASLHIQL DISPEQFTDL 360
  361 AKIVRSKLHR YGIHSATLQP EFITREVTST ERAGDSQGDH LQNDPLSLRP KTYGTGISGS 420
  421 TCLIDDAANC NTADCLEDH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) BPT1 CCC1 COT1 CTR2 FTH1 VCX1 VMA9 ZRC1 ZRT3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data COT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..439] Pfam 67.568636 Cation efflux family No confident structure predictions are available.
    2 View Details [107..439] PSI-BLAST 48.522879 No description for 2qfiA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cation transmembrane transporter activity
    		•  6.20443686476571 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  6.11479851651253 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.71521511150856 bayes_pls_golite062009
  • transporter activity
    		•  3.98293753989079 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.88313530012213 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.86867537460555 bayes_pls_golite062009
  • cadmium ion transmembrane transporter activity
    		•  3.15489440737786 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.61862894000527 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  2.19121021485065 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.14914871177232 bayes_pls_golite062009
  • cation channel activity
    		•  1.78793567733454 bayes_pls_golite062009
  • efflux transmembrane transporter activity
    		•  1.41612086977895 bayes_pls_golite062009
  • binding
    		•  1.28505954375411 bayes_pls_golite062009
  • ion channel activity
    		•  1.24140857317889 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  1.20401058605752 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.19443885425411 bayes_pls_golite062009
  • channel activity
    		•  1.19443885425411 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.19404477926718 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.475232131680683 bayes_pls_golite062009
  • protein binding
    		•  0.318355149027855 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  0.186398867523746 bayes_pls_golite062009
    2
    Term Confidence Notes
  • cation transmembrane transporter activity
    		•  6.60087208506814 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  6.49419690808578 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.066906606566 bayes_pls_golite062009
  • transporter activity
    		•  4.27173462293249 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.19993137135137 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  4.18558383943492 bayes_pls_golite062009
  • cadmium ion transmembrane transporter activity
    		•  3.5658659940326 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.68106285271045 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  2.32644140472297 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.19343183150052 bayes_pls_golite062009
  • efflux transmembrane transporter activity
    		•  2.11491587250012 bayes_pls_golite062009
  • cation channel activity
    		•  1.89531256510168 bayes_pls_golite062009
  • ion channel activity
    		•  1.33777369753101 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  1.31663166812163 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.28221434614717 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.27960450391272 bayes_pls_golite062009
  • channel activity
    		•  1.27960450391272 bayes_pls_golite062009
  • binding
    		•  1.27456652114636 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.490905558612378 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  0.376948884172728 bayes_pls_golite062009
  • protein binding
    		•  0.311357063667067 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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