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Protein Overview: GAA1

General Information:
Name(s) found: GAA1 / YLR088W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 614 amino acids

    Gene Ontology:
    Cellular Component: GPI-anchor transamidase complex [IPILink to PubMed article]
    Biological Process: attachment of GPI anchor to protein [IMPLink to PubMed article]
    Molecular Function: GPI-anchor transamidase activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLEKLHRR IVDMGLVPRI IALLPVISML CALFGFISIA ILPMDGQYRR TYISENALMP  60
   61 SQAYSYFRES EWNILRGYRS QIKEMVNMTS MERNNLMGSW LQEFGTKTAI YENEQYGETL 120
  121 YGVMHAPRGD GTEAMVLAVP WFNSDDEFNI GGAALGVSLA RFFSRWPVWS KNIIVVFSEN 180
  181 PRAALRSWVE AYHTSLDLTG GSIEAAVVLD YSSTEDFFEY VEISYDGLNG ELPNLDLVNI 240
  241 AISITEHEGM KVSLHGLPSD QLTNNNFWSR LKILCLGIRD WALSGVKKPH GNEAFSGWRI 300
  301 QSVTLKAHGN SGHDITTFGR IPEAMFRSIN NLLEKFHQSF FFYLLLAPRQ FVSISSYLPS 360
  361 AVALSIAFAI SSLNAFINNA YANISLFSEY NLVALLVWFV SLVISFVVSQ AFLLIPSSGL 420
  421 LMTISMASCF LPLILSRKIH ISEPLSYRLK NVAFLYFSLV STSLLMINFA MALLIGTLAF 480
  481 PMTFVKTIVE SSSEHEVTTQ SSNPIKTEPK DEIELVENHM DTTPATPQQQ KQKLKNLVLL 540
  541 ILTNPFISIT LFGLFFDDEF HGFDIINKLV SAWLDLKCWS WFVLCIGWLP CWLLILASSF 600
  601 ESKSVVVRSK EKQS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) GAA1 GPI8 PGI1
    View Details Qiu et al. (2008) CAX4 ERI1 GAA1 GAB1 GPI11 GPI16 GPI17 GPI8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GAA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] deduced N/A No confident structure predictions are available.
    2 View Details [310..502] MSA 1.010988 View MSA. No confident structure predictions are available.
    3 View Details [503..614] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  1.72000211894151 bayes_pls_golite062009
  • catalytic activity
    		•  1.30073863026596 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.04545175523841 bayes_pls_golite062009
  • binding
    		•  0.768831715417683 bayes_pls_golite062009
  • peptidase activity
    		•  0.700635398774672 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.362145256746391 bayes_pls_golite062009
  • metallopeptidase activity
    		•  0.177551285129758 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.171364523459 bayes_pls_golite062009
  • DNA binding
    		•  0.0535456396545306 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle