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Protein Overview: SRP40

General Information:
Name(s) found: SRP40 / YKR092C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 406 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: nucleocytoplasmic transport [ISSLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASKKIKVDE VPKLSVKEKE IEEKSSSSSS SSSSSSSSSS SSSSSSSSSG ESSSSSSSSS  60
   61 SSSSSDSSDS SDSESSSSSS SSSSSSSSSS DSESSSESDS SSSGSSSSSS SSSDESSSES 120
  121 ESEDETKKRA RESDNEDAKE TKKAKTEPES SSSSESSSSG SSSSSESESG SESDSDSSSS 180
  181 SSSSSDSESD SESDSQSSSS SSSSDSSSDS DSSSSDSSSD SDSSSSSSSS SSDSDSDSDS 240
  241 SSDSDSSGSS DSSSSSDSSS DESTSSDSSD SDSDSDSGSS SELETKEATA DESKAEETPA 300
  301 SSNESTPSAS SSSSANKLNI PAGTDEIKEG QRKHFSRVDR SKINFEAWEL TDNTYKGAAG 360
  361 TWGEKANEKL GRVRGKDFTK NKNKMKRGSY RGGSITLESG SYKFQD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SNU13 SRP40
    View Details Krogan NJ, et al. (2006) CWP2 DBP2 FLC2 PPN1 RPS31 SRP40 TFA1 TFA2 YAP1801
    View Details Qiu et al. (2008) SRP40 UTP15

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SRP40 Huh WK, et al. (2003)
    View Data SRP40 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198] PSI-BLAST 3.39794 Fibrinogen
    2 View Details [199..406] ORFEUS 10.63 No description for 1ldvA was found.
    3 View Details [285..406] Pfam 54.657577 No description for PF05022.3 was found. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle