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Protein Overview: CAF4

General Information:
Name(s) found: CAF4 / YKR036C [SGD]
Description(s) found:
Found 16 descriptions.
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  • WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 659 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    CCR4-NOT complex [IPILink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    mitochondrial fission [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYKITTSES KKEYLYMGSG DTRGESSLVA KPIEIILNKL PHAILAQQQF QKYITSPIYR  60
   61 YLSKLLLFRE VAWPESTKDT QKGQVGIFSF QNNYADSATT FRILAHLDEH GYPLPNGAAE 120
  121 KNLPSLFEGF KATVSIIQQR LLLDNVDGAT NSDKEKYVQL PDINTGFVNK TYSRIDLTHL 180
  181 LEDVETNVEN LSINKTLEMD ELTRLDSMIN ELESRKLKIL ERVKHIDSKS TNLENDVTLI 240
  241 KDRINFIEEY NLEADREQSL RKQMEEERSS EASSFTQNEE AISSLCDVES KDTRLKDFYK 300
  301 MPHEKSHDKN RQIISETYSR NTTAFRMTIP HGEHGNSITA LDFDTPWGTL CSSSYQDRIV 360
  361 KVWDLNHGIQ VGELPGHLAT VNCMQIDKKN YNMLITGSKD ATLKLWDLNL SREIYLDHSP 420
  421 LKEKTEEIVT PCIHNFELHK DEITALSFDS EALVSGSRDK KIFHWDLTTG KCIQQLDLIF 480
  481 TPTHSDIKMP ARSLNNGACL LGTEAPMIGA LQCYNSALAT GTKDGIVRLW DLRVGKPVRL 540
  541 LEGHTDGITS LKFDSEKLVT GSMDNSVRIW DLRTSSILDV IAYDLPVSSL DFDGKLITVG 600
  601 ANEGGVNVFN MERDEHWMTP EPPHSLDGDE LSRRIAIVKY KDGFLINGHN DGDINVWTL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CAF130 CAF16 CAF4 CAF40 CCR4 CDC36 CDC39 MOT2 NOT3 NOT5 POP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC13 CAF4 1 Unpublished Fields Lab Data
    View Screen UBC7 CAF4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..268] deduced N/A No confident structure predictions are available.
    2 View Details [269..659] PSI-BLAST 164.37734 beta1-subunit of the signal-transducing G protein heterotrimer
    3 View Details [240..659] PSI-BLAST 78.0 No description for 2ovpB was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle