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Protein Overview: BCH2

General Information:
Name(s) found: BCH2 / YKR027W [SGD]
Description(s) found:
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  • gi|6322879|ref|NP_012952.1| Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the pl [NCBI NR]
  • gi|549599|sp|P36122.1|BCH2_YEAST RecName: Full=Protein BCH2; AltName: Full=BUD7 and CHS6 homolog 2 [NCBI NR]
  • pir||S38099 hypothetical protein YKR027w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486455|emb|CAA82099.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P36122) Hypothetical 88.0 kDa protein in GCN3-SAP190 intergenic region [Swiss-Prot]
  • Protein BCH2 OS=Saccharomyces cerevisiae GN=BCH2 PE=1 SV=1 [Swiss-Prot]
  • FMP50 Found in Mitochondrial Proteome [mips]
  • Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane [SGD]
  • YKR027W, Chr XI from 491002-493299 [yeast_orfs2]
  • Chr XI from 491002-493299 [yeastorf3.fasta]
  • FMP50 SGDID:S0001735, Chr XI from 491007-493304, Uncharacterized ORF [yeastflysequest.fasta]
  • Fmp50p [Saccharomyces cerevisiae]gi|486455|emb|CAA82099.1| unnamed protein product [Saccharomyces cerevisiae]gi|539243|pir||S38099 hypothetical protein YKR027w - yeast (Saccharomyces cerevisiae)gi|549599|sp|P36122|YK07_YEAST HYPOTHETICAL 88.0 KD PROTEI [nrdb_11152004_Chlamydomonas]
  • YKR027W SGDID:S000001735, Chr XI from 491007-493304, Uncharacterized ORF, "The authentic, non-tagged protein was localized to the mitochondria" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • BCH2 SGDID:S000001735, Chr XI from 491007-493304, Verified ORF, "Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin [yeast-contam.fasta]
  • BCH2 SGDID:S000001735, Chr XI from 491007-493304, Verified ORF, "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, incl [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane; Bch2p [Sacchar [nr-271106-contam.fasta]
  • Hypothetical 88.0 kDa protein in GCN3-SAP190 intergenic region [nr-271106-contam.fasta]
  • BCH2 SGDID:S000001735, Chr XI from 491007-493304, Verified ORF, "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane" [yeast-bovrabprots.fasta]
  • BCH2 SGDID:S000001735, Chr XI from 491007-493304, Verified ORF, "Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Protein BCH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BCH2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • BCH2 SGDID:S000001735, Chr XI from 491364-493661, Genome Release 64-1-1, Verified ORF, "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane" [yeast-030211-contam.fasta]
  • BCH2 SGDID:S000001735, Chr XI from 491364-493661, Genome Release 64-2-1, Verified ORF, "Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YKR027W SGDID:S000001735, Chr XI from 491364-493661, Genome Release 64-1-1, Verified ORF, "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 765 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    trans-Golgi network transport vesicle [IDALink to PubMed article]
    clathrin-coated vesicle [IDALink to PubMed article]
    Biological Process: Golgi to plasma membrane transport [IGILink to PubMed article]
    cell wall chitin biosynthetic process [IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLWGSTKS KKGKNKKAAG SLPSGVVPQQ RVKPTRKNVP IDYPRTLEKV HGESLIFRTS  60
   61 LLSELVSTGK SGIGPPDLIH CTELDKFHDE KIGEFFYITG IDASSVSMPI AFLKLIKWND 120
  121 GKKLKSASLK NDDITTYCTF NIFQKLDIRL RYESEDVYQV NIVDCLNGNN EIPLSDLIWE 180
  181 ETFVSCCIRS VIINSDFERK IPGLVELPFV FENRCASDYK RVIDSLCKFL PRFLECGWDS 240
  241 TKSVYATILN NYLTESLLVF LSITPEFITD YAIQVLDNLM TNDPSNSRYY AIVIISIMER 300
  301 SNDRDVEMIK RIHEILDLLL PVLYGLPSDE PYISDLINCI TDVLSIQARF LLNNNDYELS 360
  361 LSISTLATNL SSDNFESWYL LSKGYIFSQQ YDKALLSINS MPCLAEYDIV KQAQINAFKF 420
  421 YMNYYKAPLC HSREHCTMTS HELNHLMNIM HYENELELKT IIFGRTVMPN ESKYGCIEEI 480
  481 WNKSCLELGP ICGPQSDNLI NFVSQQEVNT VGDMLLLKRS KETRQESWFI KQVRLLLMEL 540
  541 VARIGWNALL QLRSDVFVME SKFKMIESSD KLSTELRQKR LCQRWFDAMF LDVYEDLSIS 600
  601 TSSQENKATA KYSGLEWELL GLTLLRVSDL PDAVACLRTS ILARFDPISC HHLLNFYLTM 660
  661 DFNDEFMRRF DVDIILDLLV KLISFRIRFY DRFQIFSLQV LRKLEGQLGS EIIKNKIINS 720
  721 PYGQAGITSV IDYMLECLSK NRNEACLAYE RPLPDLPSTI KPLAD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BCH1 BCH2 CHS5
    View Details Krogan NJ, et al. (2006) BCH1 BCH2 CHS5 LAP2 MAE1
    View Details Qiu et al. (2008) BCH1 BCH2 BUD7 CHS6 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run SLI15 No Comments Cheeseman IM, et al. (2002)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HMT1 BCH2 1 Unpublished Fields Lab Data
    View Screen PRP16 BCH2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BCH2 Huh WK, et al. (2003)
    View Data BCH2 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..419] MSA 3.007894 View MSA. No confident structure predictions are available.
    2 View Details [420..512] deduced N/A No confident structure predictions are available.
    3 View Details [513..765] MSA 1.004904 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • drug binding
    		•  1.97908029685084 bayes_pls_golite062009
  • isomerase activity
    		•  1.19192091517095 bayes_pls_golite062009
  • catalytic activity
    		•  0.838457647933563 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  0.788209490718562 bayes_pls_golite062009
  • transporter activity
    		•  0.741927397485699 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  0.728844238348547 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.68050479178453 bayes_pls_golite062009
  • binding
    		•  0.647093863277037 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.489382802264305 bayes_pls_golite062009
  • protein binding
    		•  0.480005676233146 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.18557772671331 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle