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Protein Overview: URA1

General Information:
Name(s) found: URA1 / YKL216W [SGD]
Description(s) found:
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  • gi|6322633|ref|NP_012706.1| Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid; Ura1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|486387|emb|CAA82061.1| URA1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|4754|emb|CAA42014.1| dihydroorotate oxidase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|473134|emb|CAA53557.1| URA1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|45719888|emb|CAE52162.1| Ura1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|45719878|emb|CAE52157.1| Ura1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|171394|gb|AAA34566.1| dihydroorotic acid dehydrogenase [NCBI NR]
  • gi|131723|sp|P28272.1|PYRD_YEAST RecName: Full=Dihydroorotate dehydrogenase; Short=DHOdehase; Short=DHODase; Short=DHOD; AltName: Full=Dihydroorotate oxidase [NCBI NR]
  • pir||JC1276 dihydroorotate oxidase (EC 1.3.3.1) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Dihydroorotate dehydrogenase OS=Saccharomyces cerevisiae GN=URA1 PE=1 SV=1 [Swiss-Prot]
  • URA1 Dihydroorotate dehydrogenase [mips]
  • Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid [SGD]
  • URA1, Chr XI from 25216-26160 [yeast_orfs2]
  • Chr XI from 25216-26160 [yeastorf3.fasta]
  • (P28272) Dihydroorotate dehydrogenase (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase) [4932.FASTACCERV.txt]
  • URA1 SGDID:S0001699, Chr XI from 25216-26160, Verified ORF [yeastflysequest.fasta]
  • The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid; dihydroorotate dehydrogenase [Saccharomyces cerevisiae]gi|473134|emb|CAA53557.1| URA1 [Saccharomyces cerevisiae]gi|4754|emb|CAA42014.1| dihydroorotate oxidase [Saccharomyces cerev [nrdb_11152004_Chlamydomonas]
  • (P28272) Dihydroorotate dehydrogenase (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD) [cerv4932.FASTAC]
  • URA1 SGDID:S000001699, Chr XI from 25216-26160, Verified ORF, "Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Ura1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • URA1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • dihydroorotic acid dehydrogenase [nr-271106-contam.fasta]
  • Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid; Ura1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • dihydroorotate oxidase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Dihydroorotate dehydrogenase (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Dihydroorotate dehydrogenase (fumarate) OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • URA1 SGDID:S000001699, Chr XI from 25215-26159, Genome Release 64-1-1, Verified ORF, "Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid" [yeast-030211-contam.fasta]
  • URA1 SGDID:S000001699, Chr XI from 25215-26159, Genome Release 64-2-1, Verified ORF, "Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid" [20141208_orf_trans.fasta]
  • YKL216W SGDID:S000001699, Chr XI from 25215-26159, Genome Release 64-1-1, Verified ORF, "Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 314 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    extrinsic to membrane [IDALink to PubMed article]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [TASLink to PubMed article]
    Molecular Function: dihydroorotate dehydrogenase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTASLTTKFL NNTYENPFMN ASGVHCMTTQ ELDELANSKA GAFITKSATT LEREGNPEPR  60
   61 YISVPLGSIN SMGLPNEGID YYLSYVLNRQ KNYPDAPAIF FSVAGMSIDE NLNLLRKIQD 120
  121 SEFNGITELN LSCPNVPGKP QVAYDFDLTK ETLEKVFAFF KKPLGVKLPP YFDFAHFDIM 180
  181 AKILNEFPLA YVNSINSIGN GLFIDVEKES VVVKPKNGFG GIGGEYVKPT ALANVRAFYT 240
  241 RLRPEIKVIG TGGIKSGKDA FEHLLCGASM LQIGTELQKE GVKIFERIEK ELKDIMEAKG 300
  301 YTSIDQFRGK LNSI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GUK1 TMA7 URA1 YEL023C
    View Details Ho Y, et al. (2002) ADE3 ALA1 FPR1 HOM3 MLP2 PFK2 RHO4 SSZ1 THS1 URA1 YDR341C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data URA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..314] PSI-BLAST 1341.39794 Dihydroorotate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dihydroorotate dehydrogenase activity
    		•  2.73800716363956 bayes_pls_golite062009
  • dihydroorotate oxidase activity
    		•  2.35584458985229 bayes_pls_golite062009
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • dihydropyrimidine dehydrogenase (NADP+) activity
    		•  1.76080169529176 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.34004057547793 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
    		•  0.708198550325532 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle