YRC Public Data Repository - Protein Structure Prediction

Protein:	URA1
Organism:	Saccharomyces cerevisiae
Length:	314 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URA1.

Description	E-value	Query Range	Subject Range
URA1 - Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyr... PYRD_YEAST - Dihydroorotate dehydrogenase (fumarate) OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...	3.0E-65	[1..314]	[1..314]
PYRDA_LACLA, PYD... - Dihydroorotate dehydrogenase A OS=Lactococcus lactis subsp. lactis GN=pyrDA PE=3 SV=1, (Q9CFC9) Dihy... PYRDA_LACLA - Dihydroorotate dehydrogenase A (fumarate) OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=pyr...	2.0E-61	[5..314]	[2..311]
gi\|2098352, gi\|1... - gi\|511015\|emb\|CAA52279.1\| dihydroorotate dehydrogenase A [Lactococcus lactis], gi\|3660332\|pdb\|2DOR\|B... PYRDA_LACLM - Dihydroorotate dehydrogenase A (fumarate) OS=Lactococcus lactis subsp. cremoris (strain MG1363) GN=p... PYRDA_LACLC - Dihydroorotate dehydrogenase A (fumarate) OS=Lactococcus lactis subsp. cremoris GN=pyrDA PE=3 SV=1	1.0E-60	[5..314]	[2..311]
PYRD_PYRAB - Dihydroorotate dehydrogenase OS=Pyrococcus abyssi GN=pyrD PE=3 SV=1 PYRDB_PYRAB - Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit OS=Pyrococcus abyssi (strain GE5 / Orsay)...	7.0E-59	[5..314]	[6..303]
PYRD_RAT - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Rattus norvegicus GN=Dhodh PE=1 SV=1 gi\|4379422 - emb\|CAA56765.1\| dihydroorotate dehydrogenase [Rattus rattus]	5.0E-58	[5..309]	[78..390]
PYRDA_STRP1 - Putative dihydroorotate dehydrogenase A (fumarate) OS=Streptococcus pyogenes serotype M1 GN=pyrD PE=... gi\|71853760, gi\|... - gi\|71910978\|ref\|YP_282528.1\| dihydroorotate dehydrogenase 1A [Streptococcus pyogenes MGAS5005], gi\|7... gi\|13622526, gi\|... - gi\|15675344\|ref\|NP_269518.1\| dihydroorotate dehydrogenase 1A [Streptococcus pyogenes M1 GAS], gi\|136...	5.0E-58	[2..313]	[1..309]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-58	[5..309]	[78..390]
gi\|188595820, gi... - gi\|239781883\|pdb\|3G0X\|A Chain A, Human Dihydroorotate Dehydrogenase In Complex With A Leflunomide De...	6.0E-58	[5..309]	[50..362]
Dhod-PA, Dhod-PD - The gene Dihydroorotate dehydrogenase is referred to in FlyBase by the symbol Dmel\Dhod (CG9741, FBg... gi\|220950570, gi... - gi\|220959410\|gb\|ACL92248.1\| Dhod-PA [synthetic construct], gi\|220950570\|gb\|ACL87828.1\| Dhod-PA [synt...	2.0E-57	[5..309]	[86..396]

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Predicted Domain #1

Region A:
Residues: [1-314]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTASLTTKFL NNTYENPFMN ASGVHCMTTQ ELDELANSKA GAFITKSATT LEREGNPEPR  60
   61 YISVPLGSIN SMGLPNEGID YYLSYVLNRQ KNYPDAPAIF FSVAGMSIDE NLNLLRKIQD 120
  121 SEFNGITELN LSCPNVPGKP QVAYDFDLTK ETLEKVFAFF KKPLGVKLPP YFDFAHFDIM 180
  181 AKILNEFPLA YVNSINSIGN GLFIDVEKES VVVKPKNGFG GIGGEYVKPT ALANVRAFYT 240
  241 RLRPEIKVIG TGGIKSGKDA FEHLLCGASM LQIGTELQKE GVKIFERIEK ELKDIMEAKG 300
  301 YTSIDQFRGK LNSI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1341.39794
Match:	1dorA_
Description:	Dihydroorotate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydroorotate dehydrogenase activity	2.73800716363956	bayes_pls_golite062009
dihydroorotate oxidase activity	2.35584458985229	bayes_pls_golite062009
catalytic activity	1.94749091175302	bayes_pls_golite062009
dihydropyrimidine dehydrogenase (NADP+) activity	1.76080169529176	bayes_pls_golite062009
oxidoreductase activity	1.34004057547793	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	0.708198550325532	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: