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Protein Overview: gi|188595820, gi...

General Information:
Name(s) found: gi|239781883 [NCBI NR]
gi|239781882 [NCBI NR]
gi|239781859 [NCBI NR]
gi|239781858 [NCBI NR]
gi|239781842 [NCBI NR]
gi|188595821 [NCBI NR]
gi|188595820 [NCBI NR]
gi|188595819 [NCBI NR]
gi|114793576 [NCBI NR]
gi|10835816 [NCBI NR]
gi|10835815 [NCBI NR]
Description(s) found:
Found 16 descriptions.
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  • gi|239781883|pdb|3G0X|A Chain A, Human Dihydroorotate Dehydrogenase In Complex With A Leflunomide Derivative Inhibitor 5 [NCBI NR]
  • gi|239781882|pdb|3G0U|A Chain A, Human Dihydroorotate Dehydrogenase In Complex With A Leflunomide Derivative Inhibitor 4 [NCBI NR]
  • gi|239781859|pdb|3FJL|A Chain A, Human Dihydroorotate Dehydrogenase In Complex With A Leflunomide Derivative Inhibitor 3 [NCBI NR]
  • gi|239781858|pdb|3FJ6|A Chain A, Human Dihydroorotate Dehydrogenase In Complex With A Leflunomide Derivative Inhibitor 2 [NCBI NR]
  • gi|239781842|pdb|3F1Q|A Chain A, Human Dihydroorotate Dehydrogenase In Complex With A Leflunomide Derivative Inhibitor 1 [NCBI NR]
  • gi|188595821|pdb|2PRM|A Chain A, The Structures Of Apo- And Inhibitor Bound Human Dihydroorotate Dehydrogenase Reveal Conformational Flexibility Within The Inhibitor Binding Site [NCBI NR]
  • gi|188595820|pdb|2PRL|A Chain A, The Structures Of Apo- And Inhibitor Bound Human Dihydroorotate Dehydrogenase Reveal Conformational Flexibility Within The Inhibitor Binding Site [NCBI NR]
  • gi|188595819|pdb|2PRH|A Chain A, The Structures Of Apo- And Inhibitor Bound Human Dihydroorotate Dehydrogenase Reveal Conformational Flexibility Within The Inhibitor Binding Site [NCBI NR]
  • gi|114793576|pdb|2BXV|A Chain A, Dual Binding Mode Of A Novel Series Of Dhodh Inhibitors [NCBI NR]
  • gi|10835816|pdb|1D3H|A Chain A, Human Dihydroorotate Dehydrogenase Complexed With Antiproliferative Agent A771726 [NCBI NR]
  • gi|10835815|pdb|1D3G|A Chain A, Human Dihydroorotate Dehydrogenase Complexed With Brequinar Analog [NCBI NR]
    • Organism: Homo sapiens
    Length: 367 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATGDERFYA EHLMPTLQGL LDPESAHRLA VRFTSLGLLP RARFQDSDML EVRVLGHKFR  60
   61 NPVGIAAGFD KHGEAVDGLY KMGFGFVEIG SVTPKPQEGN PRPRVFRLPE DQAVINRYGF 120
  121 NSHGLSVVEH RLRARQQKQA KLTEDGLPLG VNLGKNKTSV DAAEDYAEGV RVLGPLADYL 180
  181 VVNVSSPNTA GLRSLQGKAE LRRLLTKVLQ ERDGLRRVHR PAVLVKIAPD LTSQDKEDIA 240
  241 SVVKELGIDG LIVTNTTVSR PAGLQGALRS ETGGLSGKPL RDLSTQTIRE MYALTQGRVP 300
  301 IIGVGGVSSG QDALEKIRAG ASLVQLYTAL TFWGPPVVGK VKRELEALLK EQGFGGVTDA 360
  361 IGADHRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..367] PSI-BLAST 83.39794 Dihydroorotate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  2.7385769437489 bayes_pls_golite062009
  • dihydroorotate dehydrogenase activity
    		•  2.73800716363956 bayes_pls_golite062009
  • dihydroorotate oxidase activity
    		•  2.35584458985229 bayes_pls_golite062009
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • dihydropyrimidine dehydrogenase (NADP+) activity
    		•  1.76080169529176 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
    		•  0.962937319088834 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.876786102965635 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.126127705865716 bayes_pls_golite062009
  • binding
    		•  0.100344139383616 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle