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Protein Overview: MNR2

General Information:
Name(s) found: MNR2 / YKL064W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 969 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    Biological Process: magnesium ion transport [ISSLink to PubMed article]
    Molecular Function: magnesium ion transmembrane transporter activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTDNSQKDE GVPLLSPYSS SPQLRKKKRN QKRRKDKFVG HLKSDSRRPT QLLHDNLQHN  60
   61 HGQITDFDQI DSWGMLHESD STSNDIIKSE DPSLKGAFID HRPSMSQPRE GPQSVSSTVQ 120
  121 PQPIMKFSTP SYKKPAGLRP SDQNRSLVSD LSPSELESWL KRRKSVHKSF VDENSPTDRR 180
  181 QSNANNDVVI DVDALMNHVN NNASTGVNDN SKRRKKKRGS DDSSNKNSKS TSSDSNDEED 240
  241 EYNSRPSSSL SSNNSSLDDV CLVLDDEGSE VPKAWPDCTV LEEFSKEETE RLRSQAIQDA 300
  301 EAFHFQYDED EEDGTSNEDG ILFSKPIVTN IDVPELGNRR VNETENLKNG RLRPKRIAPW 360
  361 HLIQRPMVLG SNSTKDSKSR IQSGLQDNLL VGRNIQYPPH IISNNPEHFR FTYFRVDLDS 420
  421 TVHSPTISGL LQPGQKFQDL FVASIYSQDN SAGHIKTHPN SPTPGIKAET VSQLQGLTAK 480
  481 NPSTLSSMSV ANIEDVPPFW LDVSNPTEEE MKILSKAFGI HPLTTEDIFL GEVREKVELF 540
  541 RDYYLICFRS FDIVAEKHVR RRRKEKQESA TLDHESISRR KSQAYGATMS NESNANNNNS 600
  601 TSNASRSKWL PSILRARRRS SANRTTNTSS SSYKRRVKSE KKKMEENEKF KRKSGDRHKP 660
  661 REGELEPLNV YIIVFRTGVL TFHFAPTPHP INVRRRARLL KDYLNVTSDW IAYALIDDIT 720
  721 DAFAPMIELI EDEVYEIEDA ILKMHQSDDS SDSDSSDSDS DSGASDEDAF PFDVYSKKTS 780
  781 YSSAKSSVSS RSMSTSEASF NANLIGWKRK GDMLRRIGEC RKRVMSILRL LGSKADVIKG 840
  841 FAKRYNEQWE ASPQSEIAMY LGDIQDHIVT MVSSLNHYEK LLSRSHSNYL AQINIDMTKV 900
  901 NNDMNDVLGK ITILGTIVLP MNVITGLWGM NVIVPGQYRD SLTWFIGIVL FMCMLACSAY 960
  961 MYTKRRFGF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MNR2 MRS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MNR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..467] deduced N/A No confident structure predictions are available.
    2 View Details [468..969] Pfam 141.79588 CorA-like Mg2+ transporter protein No confident structure predictions are available.
    3 View Details [349..490] deduced N/A No confident structure predictions are available.
    4 View Details [491..598] PSI-BLAST 27.0 No description for 2hn1A was found.
    5 View Details [599..969] PSI-BLAST 63.045757 No description for 2iubA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • magnesium ion transmembrane transporter activity
    		•  7.40755604168398 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  5.95697679196969 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.7299533695337 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.6299982367308 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  5.27287939710425 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.23707418774335 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  5.15281921018664 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  4.66978888692345 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.61933072850484 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.3669604123503 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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