YRC Public Data Repository - Protein Structure Prediction

Protein:	MNR2
Organism:	Saccharomyces cerevisiae
Length:	969 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MNR2.

Description	E-value	Query Range	Subject Range
MNR2_YEAST - Manganese resistance protein MNR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MNR2 P... MNR2 - Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has si... gi\|190409765 - gi\|190409765\|gb\|EDV13030.1\| manganese resistance protein MNR2 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..969]	[1..969]
YBCC_SCHPO - Putative metal ion transporter C27B12.12c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=... SPBC27B12.12c - CorA family magnesium ion transporter	2.0E-96	[175..557]	[212..556]
gi\|2257556 - gi\|2257556\|dbj\|BAA21448.1\| probable membrane protein YOL130w [Schizosaccharomyces pombe]	2.0E-78	[267..557]	[1..252]
gi\|15024829, gi\|... - gi\|15895127\|ref\|NP_348476.1\| magnesium/cobalt transporter CorA [Clostridium acetobutylicum ATCC 824]... gi\|25295824 - pir\|\|E97128 magnesium and cobalt transport protein CAC1852 [imported] - Clostridium acetobutylicum	1.0E-61	[601..968]	[5..353]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	9.0E-61	[652..967]	[189..449]
gi\|18978408, gi\|... - gi\|18978408\|ref\|NP_579765.1\| magnesium and cobalt transporter [Pyrococcus furiosus DSM 3638], gi\|188...	7.0E-56	[628..968]	[30..351]
gi\|7441686 - pir\|\|F71235 probable magnesium and cobalt transport protein - Pyrococcus horikoshii gi\|3256530, gi\|1... - gi\|3256530\|dbj\|BAA29213.1\| 323aa long hypothetical magnesium and cobalt transport protein [Pyrococcu...	2.0E-53	[625..968]	[5..322]

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Predicted Domain #1

Region A:
Residues: [1-467]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTDNSQKDE GVPLLSPYSS SPQLRKKKRN QKRRKDKFVG HLKSDSRRPT QLLHDNLQHN  60
   61 HGQITDFDQI DSWGMLHESD STSNDIIKSE DPSLKGAFID HRPSMSQPRE GPQSVSSTVQ 120
  121 PQPIMKFSTP SYKKPAGLRP SDQNRSLVSD LSPSELESWL KRRKSVHKSF VDENSPTDRR 180
  181 QSNANNDVVI DVDALMNHVN NNASTGVNDN SKRRKKKRGS DDSSNKNSKS TSSDSNDEED 240
  241 EYNSRPSSSL SSNNSSLDDV CLVLDDEGSE VPKAWPDCTV LEEFSKEETE RLRSQAIQDA 300
  301 EAFHFQYDED EEDGTSNEDG ILFSKPIVTN IDVPELGNRR VNETENLKNG RLRPKRIAPW 360
  361 HLIQRPMVLG SNSTKDSKSR IQSGLQDNLL VGRNIQYPPH IISNNPEHFR FTYFRVDLDS 420
  421 TVHSPTISGL LQPGQKFQDL FVASIYSQDN SAGHIKTHPN SPTPGIK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [468-969]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AETVSQLQGL TAKNPSTLSS MSVANIEDVP PFWLDVSNPT EEEMKILSKA FGIHPLTTED  60
   61 IFLGEVREKV ELFRDYYLIC FRSFDIVAEK HVRRRRKEKQ ESATLDHESI SRRKSQAYGA 120
  121 TMSNESNANN NNSTSNASRS KWLPSILRAR RRSSANRTTN TSSSSYKRRV KSEKKKMEEN 180
  181 EKFKRKSGDR HKPREGELEP LNVYIIVFRT GVLTFHFAPT PHPINVRRRA RLLKDYLNVT 240
  241 SDWIAYALID DITDAFAPMI ELIEDEVYEI EDAILKMHQS DDSSDSDSSD SDSDSGASDE 300
  301 DAFPFDVYSK KTSYSSAKSS VSSRSMSTSE ASFNANLIGW KRKGDMLRRI GECRKRVMSI 360
  361 LRLLGSKADV IKGFAKRYNE QWEASPQSEI AMYLGDIQDH IVTMVSSLNH YEKLLSRSHS 420
  421 NYLAQINIDM TKVNNDMNDV LGKITILGTI VLPMNVITGL WGMNVIVPGQ YRDSLTWFIG 480
  481 IVLFMCMLAC SAYMYTKRRF GF

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	141.79588
Match:	PF01544
Description:	CorA-like Mg2+ transporter protein

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [349-490]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGRLRPKRIA PWHLIQRPMV LGSNSTKDSK SRIQSGLQDN LLVGRNIQYP PHIISNNPEH  60
   61 FRFTYFRVDL DSTVHSPTIS GLLQPGQKFQ DLFVASIYSQ DNSAGHIKTH PNSPTPGIKA 120
  121 ETVSQLQGLT AKNPSTLSSM SV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [491-598]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANIEDVPPFW LDVSNPTEEE MKILSKAFGI HPLTTEDIFL GEVREKVELF RDYYLICFRS  60
   61 FDIVAEKHVR RRRKEKQESA TLDHESISRR KSQAYGATMS NESNANNN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.0
Match:	2hn1A
Description:	No description for 2hn1A was found.

Predicted Domain #5

Region A:
Residues: [599-969]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSTSNASRSK WLPSILRARR RSSANRTTNT SSSSYKRRVK SEKKKMEENE KFKRKSGDRH  60
   61 KPREGELEPL NVYIIVFRTG VLTFHFAPTP HPINVRRRAR LLKDYLNVTS DWIAYALIDD 120
  121 ITDAFAPMIE LIEDEVYEIE DAILKMHQSD DSSDSDSSDS DSDSGASDED AFPFDVYSKK 180
  181 TSYSSAKSSV SSRSMSTSEA SFNANLIGWK RKGDMLRRIG ECRKRVMSIL RLLGSKADVI 240
  241 KGFAKRYNEQ WEASPQSEIA MYLGDIQDHI VTMVSSLNHY EKLLSRSHSN YLAQINIDMT 300
  301 KVNNDMNDVL GKITILGTIV LPMNVITGLW GMNVIVPGQY RDSLTWFIGI VLFMCMLACS 360
  361 AYMYTKRRFG F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.045757
Match:	2iubA
Description:	No description for 2iubA was found.

Predicted functions:

Term	Confidence	Notes
magnesium ion transmembrane transporter activity	7.40755604168398	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.95697679196969	bayes_pls_golite062009
cation transmembrane transporter activity	5.7299533695337	bayes_pls_golite062009
ion transmembrane transporter activity	5.6299982367308	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	5.27287939710425	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.23707418774335	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	5.15281921018664	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	4.66978888692345	bayes_pls_golite062009
transporter activity	3.71239480053329	bayes_pls_golite062009
transmembrane transporter activity	3.61933072850484	bayes_pls_golite062009
substrate-specific transporter activity	3.3669604123503	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: