Protein Overview: GLG2

General Information:
Name(s) found:	GLG2 / YJL137C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|854560\|emb\|CAA60818.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|6322324\|ref\|NP_012398.1\| Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; Glg2p [Saccharomyces cerevisiae] [NCBI NR] gi\|1353015\|sp\|P47011.1\|GLG2_YEAST RecName: Full=Glycogenin-2; AltName: Full=Glycogenin glucosyltransferase 2; AltName: Full=Glycogen synthesis initiator protein 2 [NCBI NR] gi\|1217991\|gb\|AAA91644.1\| Glg2p [NCBI NR] pir\|\|S55176 GLG2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1015542\|emb\|CAA89432.1\| GLG2 [Saccharomyces cerevisiae] [NCBI NR] Glycogenin-2 OS=Saccharomyces cerevisiae GN=GLG2 PE=1 SV=1 [Swiss-Prot] GLG2 Self-glucosylating initiator of glycogen synthesis [mips] Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin [SGD] GLG2, Chr X from 154683-155825, reverse complement [yeast_orfs2] Chr X from 154683-155825, reverse complement [yeastorf3.fasta] Chr X from 155825-154683, reverse complement [yeastorf5.fasta] (P47011) Glycogen synthesis initiator protein GLG2 [4932.FASTACCERV.txt] GLG2 SGDID:S0003673, Chr X from 156045-154903, reverse complement, Verified ORF [yeastflysequest.fasta] Glg2p [Saccharomyces cerevisiae]gi\|1015542\|emb\|CAA89432.1\| GLG2 [Saccharomyces cerevisiae]gi\|854560\|emb\|CAA60818.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1353015\|sp\|P47011\|GLG2_YEAST Glycogen synthesis initiator protein GLG2gi\|1077838\|p [nrdb_11152004_Chlamydomonas] GLG2 SGDID:S000003673, Chr X from 156045-154903, reverse complement, Verified ORF, "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] GLG2 SGDID:S000003673, Chr X from 156124-154982, reverse complement, Verified ORF, "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin" [yeast-contam.fasta] GLG2 SGDID:S000003673, Chr X from 156123-154981, reverse complement, Verified ORF, "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin" [yeast-200209-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] GLG2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; Glg2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Glg2p [nr-271106-contam.fasta] Glycogen synthesis initiator protein GLG2 [nr-271106-contam.fasta] [chemostatdb.fasta] Glycogenin-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLG2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] GLG2 SGDID:S000003673, Chr X from 156127-154985, Genome Release 64-1-1, reverse complement, Verified ORF, "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin" [yeast-030211-contam.fasta] GLG2 SGDID:S000003673, Chr X from 156127-154985, Genome Release 64-2-1, reverse complement, Verified ORF, "Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YJL137C SGDID:S000003673, Chr X from 156127-154985, Genome Release 64-1-1, reverse complement, Verified ORF, "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	380 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	glycogen biosynthetic process [IGI]
Molecular Function:	glycogenin glucosyltransferase activity [IGI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKKVAICTL LYSRDYLPGA LTLAYQLQKL LKHAVVEDEI TLCLLIEKKL FGDEFKPQEI  60
   61 ALIRSLFKEI IIIEPLKDQE KSIEKNKANL ELLKRPELSH TLLKARLWEL VQFDQVLFLD 120
  121 ADTLPLNKEF FEILRLYPEQ TRFQIAAVPD IGWPDMFNTG VLLLIPDLDM ATSLQDFLIK 180
  181 TVSIDGADQG IFNQFFNPIC NYSKEVLHKV SPLMEWIRLP FTYNVTMPNY GYQSSPAMNF 240
  241 FQQHIRLIHF IGTFKPWSRN TTDYDDHYYQ LWRSTQRELY SECHLSNYFT HLQLGNIETE 300
  301 TNFYHEPPCL QDLLNHGKRE NQKHVDLDIT SVDRNASQKS TAEKHDIEKP TSKPQSAFKF 360
  361 DWESTDYLDR VQRAFPKPDT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ADE5,7 DAP1 GLG1 GLG2 GSY1 GSY2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#19b Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#19a Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UMP1	GLG2	1	Unpublished Fields Lab Data
View Screen	BEM1	GLG2	1	Unpublished Fields Lab Data
View Screen	PPM1	GLG2	1	Unpublished Fields Lab Data
View Screen	PTC2	GLG2	1	Unpublished Fields Lab Data
View Screen	FLO5	GLG2	1	Unpublished Fields Lab Data
View Screen	VPS17	GLG2	1	Unpublished Fields Lab Data
View Screen	APC5	GLG2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	GLG2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..298]	PSI-BLAST	279.218487	Glycogenin
2	View Details	[299..380]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transferase activity, transferring hexosyl groups	2.55498472336996	bayes_pls_golite062009
UDP-glycosyltransferase activity	2.14294822366154	bayes_pls_golite062009
catalytic activity	1.88676710996045	bayes_pls_golite062009
transferase activity	1.47184463413038	bayes_pls_golite062009
cytidylyltransferase activity	1.14240569193314	bayes_pls_golite062009
acetylgalactosaminyltransferase activity	1.09519444695756	bayes_pls_golite062009
nucleotidyltransferase activity	1.03393419806381	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.897978517422275	bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity	0.857216989692536	bayes_pls_golite062009
mannosyltransferase activity	0.64885729959093	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.521566400238457	bayes_pls_golite062009
UDP-N-acetylglucosamine diphosphorylase activity	0.513376694534047	bayes_pls_golite062009
glycogenin glucosyltransferase activity	0.355343910175944	bayes_pls_golite062009
uridylyltransferase activity	0.321928989676507	bayes_pls_golite062009
mannose-phosphate guanylyltransferase activity	0.2363835251362	bayes_pls_golite062009
guanylyltransferase activity	0.0539392112504681	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.80

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2