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Protein Overview: PPM1

General Information:
Name(s) found: PPM1 / YDR435C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 328 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: C-terminal protein amino acid methylation [IDALink to PubMed article]
    Molecular Function: C-terminal protein carboxyl methyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERIIQQTDY DALSCKLAAI SVGYLPSSGL QRLSVDLSKK YTEWHRSYLI TLKKFSRRAF  60
   61 GKVDKAMRSS FPVMNYGTYL RTVGIDAAIL EFLVANEKVQ VVNLGCGSDL RMLPLLQMFP 120
  121 HLAYVDIDYN ESVELKNSIL RESEILRISL GLSKEDTAKS PFLIDQGRYK LAACDLNDIT 180
  181 ETTRLLDVCT KREIPTIVIS ECLLCYMHNN ESQLLINTIM SKFSHGLWIS YDPIGGSQPN 240
  241 DRFGAIMQSN LKESRNLEMP TLMTYNSKEK YASRWSAAPN VIVNDMWEIF NAQIPESERK 300
  301 RLRSLQFLDE LEELKVMQTH YILMKAQW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PPM1 TUP1 2 Unpublished Fields Lab Data
    View Screen PPM1 DET1 2 Unpublished Fields Lab Data
    View Screen PPM1 CBS2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..256] MSA 13.048977 View MSA. No confident structure predictions are available.
    2 View Details [257..328] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein methyltransferase activity
    		•  4.65643463984431 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.4632173842967 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.67177992319602 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  3.4768933204909 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.91440420216458 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.91440420216458 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.45397942930513 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  2.07640017323617 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  1.63765148226572 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.52139371235933 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  1.40758086578142 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  0.817509452491588 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • binding
    		•  0.348263200169904 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.328046788565125 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.230719796976667 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle