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Protein Overview: ZAP1

General Information:
Name(s) found: ZAP1 / YJL056C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 880 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: cellular zinc ion homeostasis [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    specific RNA polymerase II transcription factor activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDALTPRDSP KRDDSMATSA ATAASAKPDA LTIGKEGIVH GHIHNYNNLT YIHGHLHHSA  60
   61 PVNDSSASAT PAAAAVADAA TSAFASGASH DMGGDCHVNE KCKEYTDCQH FEFLNYHNNP 120
  121 SLTKYNDTAT YNSNNHSFAN NFHSVASDPT SPQQNSKSDL PRRKDSWFND DLILLPSSKK 180
  181 NKPNPPPGSD DCYCTPKILE ICCDETHPKS EANIKQGESD QPTKKDISEN GNDVAIFTDV 240
  241 KNDHLMPNFN LHDQYCNSTN HDSHNHNNTV PDSFSQLMSH LSEIDCDLTC DTPCTASTSA 300
  301 TSGHKFVQDH QSSNNDDVFH KYCKFCEEST DNQPCSKHMH LESKPPQLPP KCSSLRKPTN 360
  361 TLQGTNHAYH EHILNTDMDL KILEDLCNIS SLYEVPFGKH INHHDHNNAG NGCDGSSTGN 420
  421 NENGNQTMNL LLSSINRCNP KNNLNGSNNN TAGATSTDHQ HHHHRIQFHS HKPNRNNIVN 480
  481 NSGISAANTT ADLTNNDLND LISREYSYER FRNQSEPPSL PKVTHQNQKN RRSWPTKDLE 540
  541 STDFSSLEDS LPSSISPPIQ TTSTINFNWC FKEEKNNDLK CKWKECPESC SSLFDLQRHL 600
  601 LKDHVSQDFK HPMEPLACNW EDCDFLGDDT CSIVNHINCQ HGINFDIQFA NPDSFLPGSI 660
  661 SKEKHHLLHC PNPQTHEVSK ADGAPDMTSA NDVSNIPPIK QPEQVICQWD GCNKSFSSAQ 720
  721 ELNDHLEAVH LTRGKSEYQC LWHDCHRTFP QRQKLIRHLK VHSKYKPYKC KTCKRCFSSE 780
  781 ETLVQHTRTH SGEKPYKCHI CNKKFAISSS LKIHIRTHTG EKPLQCKICG KRFNESSNLS 840
  841 KHIKTHQKKY KCSDCSKSFD DLGKLNSQKV KCALERKPYL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AIM26 APC9 BEM3 FMP27 IRA1 MDM36 MID1 NUP42 REV1 SEC20 SML1 TCO89 TOP1 YDR396W YGL024W ZAP1 ZIM17

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ZAP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] MSA 7.078997 View MSA. No confident structure predictions are available.
    2 View Details [119..286] MSA 6.222993 View MSA. No confident structure predictions are available.
    3 View Details [287..408] deduced N/A No confident structure predictions are available.
    4 View Details [409..559] MSA 37.834996 View MSA. No confident structure predictions are available.
    5 View Details [560..690] MSA 5.820994 View MSA. No confident structure predictions are available.
    6 View Details [691..787] PSI-BLAST 227.68867 Five-finger GLI1
    7 View Details [788..880] PSI-BLAST 227.68867 Five-finger GLI1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.64349785387632 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • cation binding
    		•  0.528413183335504 bayes_pls_golite062009
  • metal ion binding
    		•  0.528413183335504 bayes_pls_golite062009
  • ion binding
    		•  0.521964257640017 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.495045338513967 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.10558148421807 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle