Protein Overview: YJL045W

General Information:
Name(s) found:	YJL045W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322416\|ref\|NP_012490.1\| Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; Yjl0 [NCBI NR] gi\|1352266\|sp\|P47052.1\|DHSX_YEAST RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial; AltName: Full=Flavoprotein subunit of complex II; Short=FP; AltName: Full=SDH1b; Flags: Precursor [NCBI NR] pir\|\|S56817 probable succinate dehydrogenase (ubiquinone) (EC 1.3.5.1) flavoprotein precursor YJL045w, mitochondrial - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1008175\|emb\|CAA89336.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial OS=Saccharomyces cerevisiae GN=YJL045W PE=1 SV=1 [Swiss-Prot] Putative mitochondrial succinate dehydrogenase flavoprotein [mips] Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner [SGD] YJL045W, Chr X from 355720-357624 [yeast_orfs2] Chr X from 355720-357624 [yeastorf3.fasta] (P47052) Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial precursor (EC 1.3.5.1) (FP) (Flavoprotein subunit of complex II) [4932.FASTACCERV.txt] YJL045W SGDID:S0003581, Chr X from 355940-357844, Uncharacterized ORF [yeastflysequest.fasta] Similar to SDH1 [Saccharomyces cerevisiae]gi\|1008175\|emb\|CAA89336.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1078399\|pir\|\|S56817 probable succinate dehydrogenase (ubiquinone) (EC 1.3.5.1) flavoprotein precursor YJL045w, mitochondrial - yeas [nrdb_11152004_Chlamydomonas] YJL045W SGDID:S000003581, Chr X from 355940-357844, Uncharacterized ORF, "Similar to SDH1" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YJL045W SGDID:S000003581, Chr X from 356019-357923, Uncharacterized ORF, "Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the d [yeast-contam.fasta] YJL045W SGDID:S000003581, Chr X from 356018-357922, Uncharacterized ORF, "Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the d [yeast-200209-contam.fasta] Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial precursor (FP) (Flavoprotein subunit of complex II) [nr-271106-contam.fasta] Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; Yjl045wp [Saccharomyces cerevisi [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YJL045W SGDID:S000003581, Chr X from 356018-357922, Uncharacterized ORF, "Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner" [yeast-bovrabprots.fasta] YJL045W SGDID:S000003581, Chr X from 356019-357923, Uncharacterized ORF, "Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner" [yeast-contam_custom.fasta] [chemostatdb.fasta] Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YJL045W PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YJL045W SGDID:S000003581, Chr X from 356024-357928, Genome Release 64-1-1, Verified ORF, "Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner" [yeast-030211-contam.fasta] YJL045W SGDID:S000003581, Chr X from 356024-357928, Genome Release 64-2-1, Verified ORF, "Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
Organism:	Saccharomyces cerevisiae
Length:	634 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ][IPI]
Biological Process:	cellular respiration [IGI ][IMP]
Molecular Function:	succinate dehydrogenase (ubiquinone) activity [IGI ][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLKKGITK SYILQRTFTS SSVVRQIGEV KSESKPPAKY HIIDHEYDCV VVGAGGAGLR  60
   61 AAFGLAEAGY KTACLSKLFP TRSHTVAAQG GINAALGNMH PDDWKSHMYD TVKGSDWLGD 120
  121 QDAIHYMTRE APKSVIELEH YGMPFSRTED GRIYQRAFGG QSKDFGKGGQ AYRTCAVADR 180
  181 TGHAMLHTLY GQALKNNTHF FIEYFAMDLL THNGEVVGVI AYNQEDGTIH RFRAHKTVIA 240
  241 TGGYGRAYFS CTSAHTCTGD GNAMVSRAGF PLEDLEFVQF HPSGIYGSGC LITEGARGEG 300
  301 GFLLNSEGER FMERYAPTAK DLASRDVVSR AITMEIRAGR GVGKNKDHIL LQLSHLPPEV 360
  361 LKERLPGISE TAAVFAGVDV TQEPIPVLPT VHYNMGGIPT KWTGEALTID EETGEDKVIP 420
  421 GLMACGEAAC VSVHGANRLG ANSLLDLVVF GRAVANTIAD TLQPGLPHKP LASNIGHESI 480
  481 ANLDKVRNAR GSLKTSQIRL NMQRTMQKDV SVFRTQDTLD EGVRNITEVD KTFEDVHVSD 540
  541 KSMIWNSDLV ETLELQNLLT CATQTAVSAS KRKESRGAHA REDYAKRDDV NWRKHTLSWQ 600
  601 KGTSTPVKIK YRNVIAHTLD ENECAPVPPA VRSY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ARO1 CKB2 CUE5 LSB3 UBP15 YFR024C YJL045W YLR422W YME2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	MLP2	#33 Asynchronous SPB prep	Keck JM, et al. (2011)
View Run	MLP2	#19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#19b Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#19a Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RRN10	YJL045W	1	Unpublished Fields Lab Data
View Screen	LSM2	YJL045W	1	Unpublished Fields Lab Data
View Screen	SNP1	YJL045W	1	Unpublished Fields Lab Data
View Screen	SPE1	YJL045W	1	Unpublished Fields Lab Data
View Screen	KRI1	YJL045W	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..241] [398..483] [613..634]	PSI-BLAST	1178.0	Fumarate reductase
2	View Details	[242..397] [484..612]	PSI-BLAST	1178.0	Fumarate reductase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2