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Protein Overview: SEC6

General Information:
Name(s) found: SEC6 / YIL068C [SGD]
Description(s) found:
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  • gi|730732|sp|P32844.2|SEC6_YEAST RecName: Full=Exocyst complex component SEC6 [NCBI NR]
  • gi|6322121|ref|NP_012196.1| Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly; Sec6p [S [NCBI NR]
  • pir||S48411 SEC6 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|557801|emb|CAA86155.1| sec6 [Saccharomyces cerevisiae] [NCBI NR]
  • Exocyst complex component SEC6 OS=Saccharomyces cerevisiae GN=SEC6 PE=1 SV=2 [Swiss-Prot]
  • SEC6 Protein transport protein [mips]
  • Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly [SGD]
  • SEC6, Chr IX from 233054-235471, reverse complement [yeast_orfs2]
  • Chr IX from 233054-235471, reverse complement [yeastorf3.fasta]
  • Chr IX from 235471-233054, reverse complement [yeastorf5.fasta]
  • (P32844) Exocyst complex component SEC6 [4932.FASTACCERV.txt]
  • SEC6 SGDID:S0001330, Chr IX from 235471-233054, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Essential 88kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [Saccharomyces cerevisia [nrdb_11152004_Chlamydomonas]
  • SEC6 SGDID:S000001330, Chr IX from 235471-233054, reverse complement, Verified ORF, "Essential 88kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized t [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SEC6 SGDID:S000001330, Chr IX from 235471-233054, reverse complement, Verified ORF, "Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts wi [yeast-contam.fasta]
  • Exocyst complex component SEC6 [nr-271106-contam.fasta]
  • Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly; Sec6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • sec6 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SEC6 SGDID:S000001330, Chr IX from 235471-233054, reverse complement, Verified ORF, "Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Exocyst complex component SEC6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC6 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SEC6 SGDID:S000001330, Chr IX from 235474-233057, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly" [yeast-030211-contam.fasta]
  • SEC6 SGDID:S000001330, Chr IX from 235474-233057, Genome Release 64-2-1, reverse complement, Verified ORF, "Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p" [20141208_orf_trans.fasta]
  • TR8842|c0_g1_i1|g.6111 ORF TR8842|c0_g1_i1|g.6111 TR8842|c0_g1_i1|m.6111 type:complete len:806 (+) TR8842|c0_g1_i1:74-2491(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YIL068C SGDID:S000001330, Chr IX from 235474-233057, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_8763|g.6359 ORF asmbl_8763|g.6359 asmbl_8763|m.6359 type:complete len:806 (+) asmbl_8763:2345-4762(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_8768|g.5395 ORF ID=asmbl_8768|g.5395 ID=asmbl_8768|m.5395 type:complete len:806 (+) ID=asmbl_8768:2346-4763(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 805 amino acids

    Gene Ontology:
    Cellular Component: cellular bud tip [IPILink to PubMed article]
    exocyst [IPILink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    vesicle docking during exocytosis [TASLink to PubMed article]
    Golgi to plasma membrane transport [TASLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDPLQQVC DLIKGDLSLE RVRDIKEQLL KEKSVVEYQL NKESDKYYGE VEESLKLLNL  60
   61 SKNSVTSIKQ QINEVNKLGN DNRFAINRYD ILFRATKLYE TVNTTSSIYD RIYNFVALME 120
  121 HIERLLVAEL AEDALETGCP HLLEIHFLLT SARDFQEQVV VMAKEATEDA QRTVMKLFSR 180
  181 LSGIISKFDK LLDGLTYDIV EMARAEQISL AIRLFKIYDL EEREDLRIEA IRNIIKKKEI 240
  241 EIEKSSIKKL PNSKNTARLQ DETPKVIEYP TNKGLYQEIM SGTISTRTAP RGYKHFLING 300
  301 INNSISEMFG EMREKYVGDQ KFDVLDNMDW IFNELIIVKE HIANCCPPHW NIFEVYFDQY 360
  361 YKELHSLITD LVESEPETII ILDILAFDKT FQDTLKQDFG FTKSEVKSVI GDKEKETLFK 420
  421 DYLNLIVVKM TEWIGNLEKA EFDVFLERST PPHSDSDGLL FLDGTKTCFQ MFTQQVEVAA 480
  481 GTNQAKILVG VVERFSDLLT KRQKNWISKI SEEIKKQINY NHKYDIDPES ITPEDECPGG 540
  541 LVEYLIAVSN DQMKAADYAV AISSKYGKLV SKVYEKQITN HLEGTLDGFA EVAQCSSLGL 600
  601 ITLMFDDLRK PYQEIFSKTW YMGSQAQQIA DTLDEYLLDI KPQMNSVLFV NFIDNVIGET 660
  661 IIKFLTALSF EHSFKNKNNK FLEAMKRDFE IFYQLFVKVL DGNESKDTLI TQNFTVMEFF 720
  721 MDLSCEPIDS ILDIWQKYLE VYWDSRIDLL VGILKCRKDV SSSERKKIVQ QATEMLHEYR 780
  781 RNMEANGVDR EPTLMRRFVL EFEKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8
    View Details (MIPS) Mewes HW, et al. (2004) EXO70 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8
    View Details Krogan NJ, et al. (2006) CEF1 CLF1 ISY1 NTC20 SEC6 SNT309 SYF1 SYF2
    View Details Gavin AC, et al. (2006) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8
    View Details Gavin AC, et al. (2002) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8 VPS9
    View Details Ho Y, et al. (2002) CAR2 CCT6 DMA2 DUN1 FAR1 GPD1 GPD2 LAP4 LSP1 MDM30 PDC6 PEX7 PIL1 RAD1 SAW1 SEC6 SEN1 SEN2 STE20 UBI4 YHR033W
    View Details Qiu et al. (2008) EXO70 EXO84 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HMT1 SEC6 1 Unpublished Fields Lab Data
    View Screen ARE2 SEC6 1 Unpublished Fields Lab Data
    View Screen HRT1 SEC6 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..285] ORFEUS 12.48 Importin beta
    2 View Details [286..425] ORFEUS 12.48 Importin beta
    3 View Details [426..546] ORFEUS 12.48 Importin beta
    4 View Details [547..805] ORFEUS 12.48 Importin beta


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle