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Protein Overview: KSP1

General Information:
Name(s) found: KSP1 / YHR082C [SGD]
Description(s) found:
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  • gi|729911|sp|P38691.1|KSP1_YEAST RecName: Full=Serine/threonine-protein kinase KSP1 [NCBI NR]
  • gi|6321874|ref|NP_011950.1| Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation; Ksp1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|516233|emb|CAA56578.1| Kinase suppressing prp20-10 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|500839|gb|AAB68896.1| Yhr082cp [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S64731 serine/threonine-specific kinase KSP1 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Serine/threonine-protein kinase KSP1 OS=Saccharomyces cerevisiae GN=KSP1 PE=1 SV=1 [Swiss-Prot]
  • KSP1 Ser/thr protein kinase [mips]
  • Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10 [SGD]
  • KSP1, Chr VIII from 268460-271549, reverse complement [yeast_orfs2]
  • Chr VIII from 268460-271549, reverse complement [yeastorf3.fasta]
  • Chr VIII from 271549-268460, reverse complement [yeastorf5.fasta]
  • (P38691) Serine/threonine-protein kinase KSP1 (EC 2.7.1.-) [4932.FASTACCERV.txt]
  • KSP1 SGDID:S0001124, Chr VIII from 271549-268460, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Ksp1p [Saccharomyces cerevisiae]gi|516233|emb|CAA56578.1| Kinase suppressing prp20-10 [Saccharomyces cerevisiae]gi|729911|sp|P38691|KSP1_YEAST Serine/threonine-protein kinase KSP1gi|2133131|pir||S64731 serine/threonine-specific kinase KSP1 (EC 2.7.1.-) [nrdb_11152004_Chlamydomonas]
  • (P38691) Serine/threonine-protein kinase KSP1 (EC 2.7.1.37) [cerv4932.FASTAC]
  • KSP1 SGDID:S000001124, Chr VIII from 271550-268461, reverse complement, Verified ORF, "Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • KSP1 SGDID:S000001124, Chr VIII from 271550-268461, reverse complement, Verified ORF, "Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and S [yeast-200209-contam.fasta]
  • Kinase suppressing prp20-10 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Yhr082cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Serine/threonine-protein kinase KSP1 [nr-271106-contam.fasta]
  • Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation; Ksp1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • KSP1 SGDID:S000001124, Chr VIII from 271550-268461, reverse complement, Verified ORF, "Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Serine/threonine-protein kinase KSP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KSP1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • KSP1 SGDID:S000001124, Chr VIII from 271548-268459, Genome Release 64-1-1, reverse complement, Verified ORF, "Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10" [yeast-030211-contam.fasta]
  • KSP1 SGDID:S000001124, Chr VIII from 271548-268459, Genome Release 64-2-1, reverse complement, Verified ORF, "Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YHR082C SGDID:S000001124, Chr VIII from 271548-268459, Genome Release 64-1-1, reverse complement, Verified ORF, "Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1029 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: protein amino acid phosphorylation [IDALink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLDYEIYKE GGILNNRYQK IEDISEGSYG YVSLAKDVRE KRLVAVKYIF KLEDDGQYDG  60
   61 PQDDENDCDS SDCDDDEDTK VDTDRHENEN GNASSNNGSS REKKHNLYKH KKSLISSKVK 120
  121 SRLSNNICLE AMYEVDIQTK IGRHQNIAAL LDFFDSYIIM EYCSGGDLYE AIKADAVPKK 180
  181 TKSITHIITQ IMDAIEYVHN KGIYHRDIKP ENILISGIDW TIKLTDWGLA TTDKTSMDRN 240
  241 VGSERYMSPE LFDSNLDIKE RKEPYDCAKV DLWAMGIVFL NIVFHKNPFS IANQSDKSFC 300
  301 YFAANREALF DVFSTMAYDF FQVLRYSLTI DPANRDLKMM RTELQNLSEY TLDDEYYNNL 360
  361 DEGYEETMID GLPPQPVPPS SAPVSLPTPI SSSNKQHMPE FKKDFNFNNV NERKRSDVSQ 420
  421 NQNVASGFFK KPSTQQQKFF NQGYNTTLST HERAKSAPKF KFKKRNKYGR TDNQFSKPVN 480
  481 IEDRKKSKIL KKSRKPLGIP TPNTHMNNFF HDYKARDEFN TRDFFTPPSV QHRYMEGFSN 540
  541 NNNKQYRQNR NYNNNNNNSN NNHGSNYNNF NNGNSYIKGW NKNFNKYRRP SSSSYTGKSP 600
  601 LSRYNMSYNH NNNSSINGYA RRGSTTTVQH SPGAYIPPNA RNHHVSPTNQ FLRVPQSTAP 660
  661 DISTVLGGKP SYQEHYTQDS MDSEGDHDSD DVLFTLEEGD HDFVNGMDNL SINDHLPHTT 720
  721 VGSHNEVFVH ASTNHNNNGN NNHIDTNSTT NQYHRQYIPP PLTTSLHINN NNNESNELPD 780
  781 LLKSPASSEA HLNLSSGPID PILTGNIGNR YSHSSDSKEL EQERRLSMEQ KFKNGVYVPP 840
  841 HHRKSFNLGT QVPPMNMKTS NEATLSVSHN SVNFGGSYNS RRSSANESNP LHMNKALEKL 900
  901 SSSPGAKSSF VGFPKPLLPR NHSSTTIALQ NEDVFADSNN DAIIFEDEEY EGESDKMAHG 960
  961 KMEGGDNESS STSPDERQIF GPYEIYAQTF AGSTHDKKLG AGRKTSIQDE MVGSLEQYKN1020
 1021 NWLILQQQD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) KSP1 RIA1 SDO1
    View Details Ho Y, et al. (2002) ARO1 BCK1 CHS1 CMP2 DBP7 KOG1 KSP1 PRI2 PSY2 TPD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD6 KSP1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KSP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] PSI-BLAST 13.0 Chk2 kinase
    2 View Details [82..308] PSI-BLAST 95.228787 Type I TGF-beta receptor R4
    3 View Details [309..391] PSI-BLAST 273.9897 Calmodulin-dependent protein kinase
    4 View Details [392..463] PSI-BLAST 16.30103 Calmodulin
    5 View Details [464..556] PSI-BLAST 16.30103 Calmodulin
    6 View Details [557..1029] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.47621789723131 bayes_pls_golite062009
  • protein binding
    		•  2.22336167249906 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle