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Protein Overview: QNS1

General Information:
Name(s) found: QNS1 / YHR074W [SGD]
Description(s) found:
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  • gi|731675|sp|P38795.1|NADE_YEAST RecName: Full=Glutamine-dependent NAD(+) synthetase; AltName: Full=NAD(+) synthase [glutamine-hydrolyzing] [NCBI NR]
  • gi|6321865|ref|NP_011941.1| Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide; Qns1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S46811 hypothetical protein YHR074w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|500832|gb|AAB68889.1| Yhr074wp [Saccharomyces cerevisiae] [NCBI NR]
  • Glutamine-dependent NAD(+) synthetase OS=Saccharomyces cerevisiae GN=QNS1 PE=1 SV=1 [Swiss-Prot]
  • QNS1 Glutamine-dependent NAD Synthetase [mips]
  • Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide [SGD]
  • QNS1, Chr VIII from 246194-248338 [yeast_orfs2]
  • Chr VIII from 246194-248338 [yeastorf3.fasta]
  • (P38795) Putative glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) [4932.FASTACCERV.txt]
  • QNS1 SGDID:S0001116, Chr VIII from 246194-248338, Verified ORF [yeastflysequest.fasta]
  • Glutamine-dependent NAD Synthetase; glutamine-dependent NAD synthetase [Saccharomyces cerevisiae]gi|731675|sp|P38795|NADE_YEAST Putative glutamine-dependent NAD(+) synthetase (NAD(+) synthase [glutamine-hydrolyzing])gi|626631|pir||S46811 hypothetical pr [nrdb_11152004_Chlamydomonas]
  • QNS1 SGDID:S000001116, Chr VIII from 246195-248339, Verified ORF, "Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Yhr074wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Glutamine-dependent NAD(+) synthetase (NAD(+) synthase [glutamine-hydrolyzing]) [nr-271106-contam.fasta]
  • Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide; Qns1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Glutamine-dependent NAD(+) synthetase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=QNS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • QNS1 SGDID:S000001116, Chr VIII from 246193-248337, Genome Release 64-1-1, Verified ORF, "Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide" [yeast-030211-contam.fasta]
  • QNS1 SGDID:S000001116, Chr VIII from 246193-248337, Genome Release 64-2-1, Verified ORF, "Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide" [20141208_orf_trans.fasta]
  • TR705|c0_g1_i1|g.470 ORF TR705|c0_g1_i1|g.470 TR705|c0_g1_i1|m.470 type:complete len:715 (+) TR705|c0_g1_i1:74-2218(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YHR074W SGDID:S000001116, Chr VIII from 246193-248337, Genome Release 64-1-1, Verified ORF, "Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_8203|g.5908 ORF asmbl_8203|g.5908 asmbl_8203|m.5908 type:complete len:715 (+) asmbl_8203:73-2217(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_8205|g.4959 ORF ID=asmbl_8205|g.4959 ID=asmbl_8205|m.4959 type:complete len:715 (+) ID=asmbl_8205:73-2217(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 714 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: NAD biosynthetic process [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: NAD+ synthase (glutamine-hydrolyzing) activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHLITLATC NLNQWALDFE GNRDRILQSI KIAKERGARL RVGPELEITG YGCLDHFLEN  60
   61 DVCLHSWEMY AQIIKNKETH GLILDIGMPV LHKNVRYNCR LLSLDGEILF IRPKIWLAND 120
  121 GNYREMRFFT PWMKPGVVED FILPPEIQKV TGQRLVPFGD AVINSLDTCI GTETCEELFT 180
  181 PQSPHIAMSL DGVEIMTNSS GSHHELRKLN KRLDLILNAT KRCGGVYLYA NQRGCDGDRL 240
  241 YYDGCALIAI NGTIVAQGSQ FSLDDVEVVT ATVDLEEVRS YRAAVMSRGL QASLAEIKFK 300
  301 RIDIPVELAL MTSRFDPTVC PTKVREPFYH SPEEEIALGP ACWMWDYLRR CNGTGFFLPL 360
  361 SGGIDSCATA MIVHSMCRLV TDAAQNGNEQ VIKDVRKITR SGDDWIPDSP QDLASKIFHS 420
  421 CFMGTENSSK ETRNRAKDLS NAIGSYHVDL KMDSLVSSVV SLFEVATGKK PIYKIFGGSQ 480
  481 IENLALQNIQ ARLRMVLSYL FAQLLPWVRG IPNSGGLLVL GSANVDECLR GYLTKYDCSS 540
  541 ADINPIGGIS KTDLKRFIAY ASKQYNMPIL NDFLNATPTA ELEPMTKDYV QSDEIDMGMT 600
  601 YEELGVFGYL RKVEKCGPYS MFLKLLHQWS PKLTPRQISE KVKRFFFFYA INRHKQTVLT 660
  661 PSYHAEQYSP EDNRFDLRPF LINPRFPWAS RKIDEVVEQC EAHKGSTLDI MSID

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CPR6 QNS1
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C
    View Details Ho Y, et al. (2002) ADH2 CAF120 CPR6 QNS1 RCN2 SLP1 TRR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data QNS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] PSI-BLAST 51.39794 hypothetical protein yl85
    2 View Details [314..658] PSI-BLAST 133.27013 NH3-dependent NAD+-synthetase
    3 View Details [659..714] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.8930848757764 bayes_pls_golite062009
  • catalytic activity
    		•  1.64442398754697 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.35962310800332 bayes_pls_golite062009
  • binding
    		•  1.19055167016953 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle